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Dive into the research topics where Daniel A. Donoho is active.

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Featured researches published by Daniel A. Donoho.


World Neurosurgery | 2015

Evaluation of Effect of Weekend Admission on the Prevalence of Hospital-Acquired Conditions in Patients Receiving Cervical Fusions

Timothy Wen; Matthew Pease; Frank J. Attenello; Alexander Tuchman; Daniel A. Donoho; Steven Cen; William J. Mack; Frank L. Acosta

BACKGROUND Hospital-acquired conditions (HACs) are defined by the Centers for Medicaid and Medicare Services (CMS) as preventable adverse events that do not qualify for reimbursement of resulting hospital costs. HACs have been employed as a metric for quality of patient care. Patients undergoing cervical spine fusions are at risk for occurrence of HACs because of limited mobility and potential extended hospital length of stay (LOS). Previous studies have not evaluated the contribution of weekend admission on the rate of HACs in this patient population. We abstracted data from the Nationwide Inpatient Sample to evaluate rate of HACs as a function of weekend admission among patients admitted for cervical fusions. METHODS Patients undergoing anterior and posterior cervical fusions were identified from the 2002-2010 Nationwide Inpatient Sample database. HACs as defined by the CMS were collected via International Classification of Diseases, Ninth Revision, Clinical Modification codes. Multivariate analysis, including adjustment for demographics, disease severity, admission acuity, and admission source, was used to evaluate the effect of weekend admission on HAC occurrence, prolonged LOS, and higher inpatient costs. RESULTS During the period 2002-2010, 1,404,181 admissions for cervical fusion were identified. HACs occurred at a frequency of 4.6%. After multivariate adjustment for demographics, disease severity, and urgency of admission, weekend admissions were associated with a 56% increased risk of HAC occurrence compared with weekday admissions (relative risk = 1.56, 95% confidence interval = 1.51, 1.62, P < 0.01). HAC occurrence was independently associated with prolonged LOS and higher inpatient costs (P < 0.05). CONCLUSIONS Patients undergoing cervical fusions who are admitted on weekends have an increased rate of HACs. HACs were associated with increases in LOS and hospital costs. Further study is warranted to evaluate disparities and potential improvement among weekend admissions.


Journal of Neuro-oncology | 2018

Predictors of 30- and 90-day readmission following craniotomy for malignant brain tumors: analysis of nationwide data

Daniel A. Donoho; Timothy Wen; Robin Babadjouni; William S. Schwartzman; Ian A. Buchanan; Steven Cen; Gabriel Zada; William J. Mack; Frank J. Attenello

Hospital readmissions are a major contributor to increased health care costs and are associated with worse patient outcomes after neurosurgery. We used the newly released Nationwide Readmissions Database (NRD) to describe the association between patient, hospital and payer factors with 30- and 90-day readmission following craniotomy for malignant brain tumor. All adult inpatients undergoing craniotomy for primary and secondary malignant brain tumors in the NRD from 2013 to 2014 were included. We identified all cause readmissions within 30- and 90-days following craniotomy for tumor, excluding scheduled chemotherapeutic procedures. We used univariate and multivariate models to identify patient, hospital and administrative factors associated with readmission. We identified 27,717 admissions for brain tumor craniotomy in 2013–2014, with 3343 (13.2%) 30-day and 5271 (25.7%) 90-day readmissions. In multivariate analysis, patients with Medicaid and Medicare were more likely to be readmitted at 30- and 90-days compared to privately insured patients. Patients with two or more comorbidities were more likely to be readmitted at 30- and 90-days, and patients discharged to skilled nursing facilities or home health care were associated with increased 90-day readmission rates. Finally, hospital procedural volume above the 75th percentile was associated with decreased 90-day readmission rates. Patients treated at high volume hospitals are less likely to be readmitted at 90-days. Insurance type, non-routine discharge and patient comorbidities are predictors of postoperative non-scheduled readmission. Further studies may elucidate potentially modifiable risk factors when attempting to improve outcomes and reduce cost associated with brain tumor surgery.


Pituitary | 2017

Management of aggressive growth hormone secreting pituitary adenomas

Daniel A. Donoho; Namrata Bose; Gabriel Zada; John D. Carmichael

Aggressive GH-secreting pituitary adenomas (GHPAs) represent an important clinical problem in patients with acromegaly. Surgical therapy, although often the mainstay of treatment for GHPAs, is less effective in aggressive GHPAs due to their invasive and destructive growth patterns, and their proclivity for infrasellar invasion. Medical therapies for GHPAs, including somatostatin analogues and GH receptor antagonists, are becoming increasingly important adjuncts to surgical intervention. Stereotactic radiosurgery serves as an important fallback therapy for tumors that cannot be cured with surgery and medications. Data suggests that patients with aggressive and refractory GHPAs are best treated at dedicated tertiary pituitary centers with multidisciplinary teams of neuroendocrinologists, neurosurgeons, radiation oncologists and other specialists who routinely provide advanced care to GHPA patients. Future research will help clarify the defining features of “aggressive” and “atypical” PAs, likely based on tumor behavior, preoperative imaging characteristics, histopathological characteristics, and molecular markers.


Neurosurgery Clinics of North America | 2015

Imaging of central neurocytomas.

Daniel A. Donoho; Gabriel Zada

Central neurocytoma (CN) is an important consideration in the differential diagnosis of any intraventricular lesion. Initial evaluation should include noncontrast CT, MRI with and without gadolinium contrast, and magnetic resonance (MR) spectroscopy, if available. CN classically appear as a partially calcified mass on CT, arising from the septum pellucidum or foramen of Monro, with a soap-bubble multicystic appearance on MR T2-imaging and heterogeneous enhancement on MR T1 postcontrast imaging. MR perfusion/permeability and dynamic contrast imaging are experimental and promising tools in the diagnosis of CN.


Journal of Neurosurgery | 2018

Long-term surgical outcomes following transsphenoidal surgery in patients with Rathke’s cleft cysts

Michelle Lin; Michelle A. Wedemeyer; Daniel Bradley; Daniel A. Donoho; Vance Fredrickson; Martin H. Weiss; John D. Carmichael; Gabriel Zada

OBJECTIVERathkes cleft cysts (RCCs) are benign epithelial lesions of the sellar region typically treated via a transsphenoidal approach with cyst fenestration and drainage. At present, there is limited evidence to guide patient selection for operative treatment. Furthermore, there is minimal literature describing factors contributing to cyst recurrence.METHODSThe authors conducted a retrospective analysis of 109 consecutive cases of pathology-confirmed RCCs treated via a transsphenoidal approach at a single center from 1995 to 2016. The majority of cases (86.2%) involved cyst fenestration, drainage, and partial wall resection. Long-term outcomes were analyzed.RESULTSA total of 109 surgeries in 100 patients were included, with a mean follow-up duration of 67 months (range 3-220 months). The mean patient age was 44.6 years (range 12-82 years), and 73% were women. The mean maximal cyst diameter was 14.7 mm. Eighty-eight cases (80.7%) were primary operations, and 21 (19.3%) were reoperations. Intraoperative CSF leak repair was performed in 53% of cases and was more common in reoperation cases (71% vs 48%, p < 0.001). There were no new neurological deficits or perioperative deaths. Two patients (1.8%) developed postoperative CSF leaks. Transient diabetes insipidus (DI) developed in 24 cases (22%) and permanent DI developed in 6 (5.5%). Seven cases (6.4%) developed delayed postoperative hyponatremia. Of the 66 patients with preoperative headache, 27 (44.3%) of 61 reported postoperative improvement and 31 (50.8%) reported no change. Of 31 patients with preoperative vision loss, 13 (48.1%) reported subjective improvement and 12 (44.4%) reported unchanged vision. Initial postoperative MRI showed a residual cyst in 25% of cases and no evidence of RCC in 75% of cases. Imaging revealed evidence of RCC recurrence or progression in 29 cases (26.6%), with an average latency of 28.8 months. Of these, only 10 (9.2% of the total 109 cases) were symptomatic and underwent reoperation.CONCLUSIONSTranssphenoidal fenestration and drainage of RCCs is a safe and effective intervention for symptomatic lesions, with many patients experiencing improvement of headaches and vision. RCCs show an appreciable (although usually asymptomatic) recurrence rate, thereby mandating serial follow-up. Despite this, full RCC excision is typically not recommended due to risk of hypopituitarism, DI, and CSF leaks.


Journal of Neurosurgery | 2018

Factors associated with burnout among US neurosurgery residents: a nationwide survey

Frank J. Attenello; Ian A. Buchanan; Timothy Wen; Daniel A. Donoho; Shirley McCartney; Steven Cen; Alexander A. Khalessi; Aaron A. Cohen-Gadol; Joseph S. Cheng; William J. Mack; Clemens M. Schirmer; Karin R. Swartz; J. Adair Prall; Ann R. Stroink; Steven L. Giannotta; Paul Klimo

OBJECTIVEExcessive dissatisfaction and stress among physicians can precipitate burnout, which results in diminished productivity, quality of care, and patient satisfaction and treatment adherence. Given the multiplicity of its harms and detriments to workforce retention and in light of the growing physician shortage, burnout has garnered much attention in recent years. Using a national survey, the authors formally evaluated burnout among neurosurgery trainees.METHODSAn 86-item questionnaire was disseminated to residents in the American Association of Neurological Surgeons database between June and November 2015. Questions evaluated personal and workplace stressors, mentorship, career satisfaction, and burnout. Burnout was assessed using the previously validated Maslach Burnout Inventory. Factors associated with burnout were determined using univariate and multivariate logistic regression.RESULTSThe response rate with completed surveys was 21% (346/1643). The majority of residents were male (78%), 26-35 years old (92%), in a stable relationship (70%), and without children (73%). Respondents were equally distributed across all residency years. Eighty-one percent of residents were satisfied with their career choice, although 41% had at some point given serious thought to quitting. The overall burnout rate was 67%. In the multivariate analysis, notable factors associated with burnout included inadequate operating room exposure (OR 7.57, p = 0.011), hostile faculty (OR 4.07, p = 0.008), and social stressors outside of work (OR 4.52, p = 0.008). Meaningful mentorship was protective against burnout in the multivariate regression models (OR 0.338, p = 0.031).CONCLUSIONSRates of burnout and career satisfaction are paradoxically high among neurosurgery trainees. While several factors were predictive of burnout, including inadequate operative exposure and social stressors, meaningful mentorship proved to be protective against burnout. The documented negative effects of burnout on patient care and health care economics necessitate further studies for potential solutions to curb its rise.


World Neurosurgery | 2018

Predictors of Surgical Site Infection After Nonemergent Craniotomy: A Nationwide Readmission Database Analysis

Ian A. Buchanan; Daniel A. Donoho; Arati Patel; Michelle Lin; Timothy Wen; Li Ding; Steven L. Giannotta; William J. Mack; Frank J. Attenello

OBJECTIVE Surgical site infections (SSIs) carry significant patient morbidity and mortality and are a major source of readmissions after craniotomy. Because of their deleterious effects on health care outcomes and costs, identifying modifiable risk factors holds tremendous value. However, because SSIs after craniotomy are rare and most existing data comprise single-institution studies with small sample sizes, many are likely underpowered to discern for such factors. The objective of this study was to use a large hetereogenous patient sample to determine SSI incidence after nonemergent craniotomy and identify factors associated with readmission and subsequent need for wound washout. METHODS We used the 2010-2014 Nationwide Readmissions Database cohorts to discern for factors predictive of SSI and washout. RESULTS We identified 93,920 nonemergent craniotomies. There were 2079 cases of SSI (2.2%) and 835 reoperations for washout (0.89%) within 30 days of index admission and there were 2761 cases of SSI (3.6%) and 1220 reoperations for washout (1.58%) within 90 days. Several factors were predictive of SSI in multivariate analysis, including tumor operations, external ventricular drain (EVD), age, length of stay, diabetes, discharge to an intermediate-care facility, insurance type, and hospital bed size. Many of these factors were similarly implicated in reoperation for washout. CONCLUSIONS SSI incidence in neurosurgery is low and most readmissions occur within 30 days. Several factors predicted SSI after craniotomy, including operations for tumor, younger age, hospitalization length, diabetes, discharge to institutional care, larger hospital bed size, Medicaid insurance, and presence of an EVD. Diabetes and EVD placement may represent modifiable factors that could be explored in subsequent prospective studies for their associations with cranial SSIs.


Neurosurgery | 2018

Increased Hospital Surgical Volume Reduces Rate of 30- and 90-Day Readmission After Acoustic Neuroma Surgery

Robin Babadjouni; Timothy Wen; Daniel A. Donoho; Ian A. Buchanan; Steven Cen; Rick A. Friedman; Arun Paul Amar; Jonathan J. Russin; Steven L. Giannotta; William J. Mack; Frank J. Attenello

BACKGROUND Hospital readmissions are commonly linked to elevated health care costs, with significant financial incentive introduced by the Affordable Care Act to reduce readmissions. OBJECTIVE To study the association between patient, hospital, and payer factors with national rate of readmission in acoustic neuroma surgery. METHODS All adult inpatients undergoing surgery for acoustic neuroma in the newly introduced Nationwide Readmissions Database from 2013 to 2014 were included. We identified readmissions for any cause with a primary diagnosis of neurological, surgical, or systemic complication within 30- and 90-d after undergoing acoustic neuroma surgery. Multivariable models were employed to identify patient, hospital, and administrative factors associated with readmission. Hospital volume was measured as the number of cases per year. RESULTS We included patients representing a weighted estimate of 4890 admissions for acoustic neuroma surgery in 2013 and 2014, with 355 30-d (7.7%) and 341 90-d (9.1%) readmissions. After controlling for patient, hospital, and payer factors, procedural volume was significantly associated with 30-d readmission rate (OR [odds ratio] 0.992, p = 0.03), and 90-d readmission rate (OR 0.994, p = 0.047). The most common diagnoses during readmission in both 30- and 90-d cohorts included general central nervous system complications/deficits, hydrocephalus, infection, and leakage of cerebrospinal fluid (rhinorrhea/otorrhea). CONCLUSION After controlling for patient, hospital, and payer factors, increased procedural volume is associated with decreased 30- and 90-d readmission rate for acoustic neuroma surgery. Future studies seeking to improve outcomes and reduce cost in acoustic neuroma surgery may seek to further evaluate the role of hospital procedural volume and experience.


Journal of Neurosurgery | 2017

The effect of NACHRI children’s hospital designation on outcome in pediatric malignant brain tumors

Daniel A. Donoho; Timothy Wen; Jonathan Liu; Hosniya Zarabi; Eisha Christian; Steven Cen; Gabriel Zada; J. Gordon McComb; Mark D. Krieger; William J. Mack; Frank J. Attenello


Epilepsy Research | 2017

Preventable complications in epilepsy admissions: The “July effect”

Natalie S. Pierson; Daniel R. Kramer; Timothy Wen; Lianne Ho; Arati Patel; Daniel A. Donoho; Vivek A. Mehta; Christianne Heck; Brian Lee; William J. Mack; Charles Y. Liu

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Gabriel Zada

University of Southern California

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William J. Mack

University of Southern California

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Frank J. Attenello

University of Southern California

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Ian A. Buchanan

University of Southern California

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John D. Carmichael

University of Southern California

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Steven Cen

University of Southern California

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Timothy Wen

University of Southern California

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Steven L. Giannotta

University of Southern California

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Michelle Lin

University of Southern California

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Martin H. Weiss

University of Southern California

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