Daniel A. Tobin

Management of stage II glottic cancer.

Abstract A detailed retrospective analysis was done of 55 patients with Stage II (T 2 N 0 M 0 ) glottic cancer, treated at the University of Louisville Radiation Center from October, 1953 to December, 1975. Ninety-one percent of the patients were male. Eighty-five percent of the patients had squamous cell carcinoma. The five year adjusted survival rate was 81% with a standard error of 5%. Twenty-seven percent of the patients had local failure and 58% of them were salvaged by further surgery. The median time to recurrence was eleven months. There was no case of laryngeal necrosis, and good function of the larynx was achieved in the majority of the patients. Eight second canters were diagnosed during the continued follow-up of these patients. A brief review of the literature is included.

Primary irradiation of stage I and stage II adenocarcinoma of the breast

Abstract This preliminary report documents the experience of the 33 member institutions of the Radiation Therapy Oncology Group with the first one hundred patients entered into a registry for adenocarcinoma of the breast treated with primary radiation therapy. The age of the patients, menstrual status, indications for radiation management, degree of surgery employed, as well as the method of treatment, and subsequent results are reviewed. Local control has been achieved in 85 patients with Stage I and Stage II adenocarcinoma of the breast.

Radiation Therapy of Glottic Carcinoma Stage I

A detailed retrospective analysis of 81 patients with a diagnosis of glottic carcinoma stage I (T1N0M0) from 1953 to 1975 has been done. Eighty-eight per cent of the patients were male and 80 per cent of the total number were white. The majority of the patients received a dose of 64 Gy in 6 1/2 weeks. The crude 5-year actuarial survival rate was 69 per cent and the adjusted 5-year actuarial survival rate was 86 per cent. Local recurrence occurred in 12 per cent and of these 80 per cent were cured by surgery. The median time of recurrence was 25.5 months. No case of laryngeal necrosis occurred, and 10 second malignant tumors were diagnosed in the follow-up.

Management of early glottic cancer

A detailed retrospective analysis of 136 patients with early glottic cancer treated at the University of Louisville, Radiation Center from October, 1953 to December, 1975 was done. Majority of the patients were in the age range of 55 to 74 years. Of them, 89% were male and 85% were Caucasian. The most common histological type was squamous cell carcinoma. The adjusted 5-year survival rate was 84%, with a standard error of 3%. Of these patients, 18% had local failures, and 68% of which were salvaged by surgery. The overall local control rate was 93%. The median time to recurrence was 23 months. There was no case of laryngeal necrosis, and a good function of larynx was achieved in a majority of the patients. Eighteen second cancers were diagnosed in 17 patients during the follow-up. A brief review of the literature is also done in the paper.