Daniel Berretta Moreira Alves

Depletion of Langerhans cells in the tongue from patients with advanced-stage acquired immune deficiency syndrome: relation to opportunistic infections

Gondak R O, Alves D B, Silva L F F, Mauad T & Vargas P A 
(2012) Histopathology 60, 497–503
Depletion of Langerhans cells in the tongue from patients with advanced‐stage acquired immune deficiency syndrome: relation to opportunistic infections

Traumatic ulcerative granuloma with stromal eosinophilia of the palate showing an angiocentric/angiodestructive growth pattern

Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a benign, self-limiting lesion of the oral mucosa with unknown pathogenesis. A 65-year-old male patient presented with an ulcerative palate lesion, which on microscopic examination exhibited an exuberant polymorphic lymphoid proliferation, numerous eosinophils, and extensive vascular destruction. The atypical lymphoid cells infiltrating the medium-sized vessels showed positivity for CD3, CD30, and granzyme B, implicating an activated cytotoxic T-cell phenotype. The lesion diagnosed as TUGSE achieved complete resolution within 3 months. This unusual presentation has expanded the spectrum of oral CD30+ T-cell atypical infiltrates and must be distinguished from lymphomas showing angiocentric/angiodestructive growth pattern.

Clinical and radiographic features of Hutchinson-Gilford progeria syndrome: A case report.

Hutchinson-Gilford progeria syndrome (HGPS) is a rare dysmorphic syndrome characterized by several features of premature aging with clinical involvement of the skin, bones, and cardiovascular system. HGPS has an estimated incidence of one in four million to one in eight million births. The main clinical features of HGPS include short stature, craniofacial dimorphism, alopecia, bone fragility, and cardiovascular disorders. The most frequent cause of death is myocardial infarction at a mean age of 13 years old. Dental manifestations include delayed development and eruption of teeth, discoloration, crowding and rotation of teeth, and displaced teeth. Cone beam computed tomography images revealed the absence of the sphenoid, frontal, and maxillary sinus, flattening of the condyles and glenoid fossa, and bilateral hypoplasia of the mandibular condyles. The disease is caused by mutations in lamin A/C (LMNA). Here, we present a case report of an 11-year-old boy with classical features of HGPS, which was caused by a de novo germ-line mutation (C1824T, G608G) in exon 11 of the LMNA gene. Some uncommon HGPS-associated features in our patient, such as alterations in the facial sinuses and hypoplasia of the condyles, contributed to the expansion of the phenotypic spectrum of this syndrome from a dentomaxillofacial perspective.

Evaluation of mandibular odontogenic keratocyst and ameloblastoma by panoramic radiograph and computed tomography

OBJECTIVES: The purpose of this study was to describe and compare the main imagenological features of mandibular ameloblastomas and odontogenic keratocyst (OKC) using panoramic radiograph (PR) and CT. METHODS: The sample consisted of nine cases of ameloblastomas and nine cases of OKC. PR and CT images were analyzed according to shape, internal structure, borders, associated unerupted tooth, root resorption, expansion and perforation of cortical bones. RESULTS: PR evaluation allowed the identification of the lesions location, presence of sclerosis in the periphery, presence of associated non-erupted tooth and expansion of the mandibles lower border cortical bone. CT was more accurate than PR in the assessment of the lesion shape, presence of inner bone septa, root resorption, buccolingual expansion and rupture of cortical bone. Most cases of ameloblastoma and OKC presented buccolingual expansion and erosion of cortical bone. Only ameloblastomas showed tooth root resorption. CONCLUSIONS: Although PR is very helpful and widely used, CT provides more precise information on buccolingual expansion, calcification, bone septa, perforation of cortical bones and tooth resorption, features that are frequently underdescribed in the literature, particularly in OKC.

Extranodal Rosai-Dorfman Disease Involving Maxilla

MARTINS, ANTONIO MARCIO MARCHIONNI, ALENA PEIXOTO MEDRADO, SILVIA REGINA ALMEIDA REIS. ESCOLA BAHIANA DE MEDICINA E SAÚDE PÚBLICAPPGO MESTRADO EM ESTOMATOLOGIA. Dermoid cyst is often used to describe three closely related histologic cysts, but dermoid, epidermoid, and teratoma cysts are considered rare in the floor of the mouth. Epidermal cysts seldom occur in the head and neck region compared to dermoid cysts, and when they do occur, they involve the floor of the mouth. Histologically, all dermoid cysts are lined by epidermis. Cyst lining content determines the histological categories of these cysts. They are epidermoid if epidermis lines the cyst, dermoid if skin annexes exist, and teratoid if tissues are derived from the three germinal layers. Anatomical classification helps determine whether the surgical approach should be intraoral or extraoral. This report presents a case of dermoid cyst of the floor of the mouth. The cyst was excised and confirmed histopathologically. The patient’s clinical course and recovery after surgery were uneventful, and no recurrence developed postoperatively.