Daniel J. Rader
Harvard University
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Featured researches published by Daniel J. Rader.
Essentials of Genomic and Personalized Medicine | 2010
Sekar Kathiresan; Daniel J. Rader
Publisher Summary Plasma lipoproteins are integral to energy and cholesterol metabolism. Disorders involving lipoprotein metabolism can predispose to atherosclerotic vascular disease. Genetic factors play an important role in influencing lipoprotein metabolism and, therefore, plasma levels of major lipoproteins and risk for cardiovascular disease. Molecular characterization of classic Mendelian monogenic lipoprotein disorders provides insights into the physiology and regulation of lipoprotein metabolism, and new targets for therapeutic drug development. Lipoprotein metabolism is increasingly available for the application of genomic medicine because of the frequency with which plasma lipids are measured in clinical practice, the quantitative importance of genetics in determining their levels, the large number of gene products involved in lipoprotein metabolism, and the broad clinical relevance of the field to the most important cause of morbidity and mortality in most of the world. Lipoproteins are large macromolecular complexes that transport hydrophobic lipids through body fluids to and from tissues. Lipoproteins play an essential role in the absorption of dietary cholesterol, long-chain fatty acids, and fat-soluble vitamins; transport of triglycerides, cholesterol, and fat-soluble vitamins from the liver to peripheral tissues; and transport of cholesterol from peripheral tissues to the liver.
Archive | 2017
Kiran Musunuru; Guillaume Lettre; Taylor Young; Deborah N. Farlow; James P. Pirruccello; Kenechi G. Ejebe; Qiong Yang; Ming Huei Chen; Nina Lapchyk; Liuda Ziaugra; Emelia J. Benjamin; L. Adrienne Cupples; Myriam Fornage; Ervin R. Fox; Joel N. Hirschhorn; Christopher H. Newton; Marcia M. Nizzari; Dina N. Paltoo; George J. Papanicolaou; Sanjay R. Patel; Bruce M. Psaty; Daniel J. Rader; Stephen S. Rich; Jerome I. Rotter; Herman A. Taylor; Russell P. Tracy; James G. Wilson; Sekar Kathiresan; Richard R. Fabsitz; Eric Boerwinkle
Journal of the American College of Cardiology | 2017
Amit Khera; Connor A. Emdin; Isabel Drake; Pradeep Natarajan; Alexander G. Bick; Nancy R. Cook; Daniel I. Chasman; Usman Baber; Roxana Mehran; Daniel J. Rader; Valentin Fuster; Eric Boerwinkle; Melander Olle; Marju Orho-Melander; Paul M. Ridker; Sekar Kathiresan
Archive | 2016
Margarita de la Llera-Moya; Denise Drazul-Schrader; Bela F. Asztalos; Marina Cuchel; Daniel J. Rader; George H. Rothblat
Genomic and Personalized Medicine (Second Edition)#R##N#V1-2 | 2013
Sekar Kathiresan; Daniel J. Rader
Archive | 2012
Robert S. Rosenson; H. Bryan; W. Sean Davidson; Zahi Fayad; Valentin Fuster; James A. Goldstein; Marc Hellerstein; Xian-Cheng Jiang; Michael C. Phillips; Daniel J. Rader; Alan T. Remaley; George H. Rothblat; Alan R. Tall; Laurent Yvan-Charvet
Archive | 2011
Amit Khera; Marina Cuchel; Daniel J. Rader
Atherosclerosis Supplements | 2009
George H. Rothblat; M Moya; Daniel J. Rader; Marina Cuchel
Atherosclerosis Supplements | 2006
Marina Cuchel; Sissel Lund-Katz; M. De La Llera-Moya; George H. Rothblat; Michael C. Phillips; Daniel J. Rader