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Dive into the research topics where Daniel Kam Yin Chan is active.

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Featured researches published by Daniel Kam Yin Chan.


Annals of Neurology | 2005

GSK3B polymorphisms alter transcription and splicing in Parkinson's disease

John B. Kwok; Marianne Hallupp; Clement Loy; Daniel Kam Yin Chan; Jean Woo; George D. Mellick; Daniel D. Buchanan; Peter A. Silburn; Glenda M. Halliday; Peter R. Schofield

Parkinsons disease (PD) is a neurodegenerative disorder characterized by a combination of motor symptoms. We identified two functional single nucleotide polymorphisms in the glycogen synthase kinase‐3β gene (GSK3B). A promoter single nucleotide polymorphism (rs334558) is associated with transcriptional strength in vitro in which the T allele has greater activity. An intronic single nucleotide polymorphism (rs6438552) regulates selection of splice acceptor sites in vitro. The T allele is associated with altered splicing in lymphocytes and increased levels of GSK3B transcripts that lack exons 9 and 11 (GSKΔexon9+11). Increased levels of GSKΔexon9+11 correlated with enhanced phosphorylation of its substrate, Tau. In a comparison of PD and control brains, there was increased in frequency of T allele (rs6438552) and corresponding increase in GSKΔexon9+11 and Tau phosphorylation in PD brains. Conditional logistic regression indicated gene–gene interaction between T/T genotype of rs334558 and H1/H1 haplotype of microtubule‐associated protein Tau (MAPT) gene (p = 0.009). There was association between a haplotype (T alleles of both GSK3B polymorphisms) and disease risk after stratification by Tau haplotypes ((H1/H2+H2/H2 individuals: odds ratio, 1.64; p = 0.007; (H1/H1 individuals: odds ratio, 0.68; p < 0.001). Ours results suggest GSK3B polymorphisms alter transcription and splicing and interact with Tau haplotypes to modify disease risk in PD. Ann Neurol 2005;58:829–839


Journal of Neurology, Neurosurgery, and Psychiatry | 1998

Genetic and environmental risk factors for Parkinson’s disease in a Chinese population

Daniel Kam Yin Chan; Jean Woo; S.C. Ho; Calvin P. Pang; L. K. Law; Ping Wing Ng; W. T. Hung; T. Kwok; Elsie Hui; K Orr; M F Leung; R. Kay

An epidemiological study of the environmental and genetic factors as well as the possible interplay between them was conducted among 215 patients with Parkinson’s disease and 313 controls in a Chinese population in Hong Kong. In univariate analysis, a regular tea drinking habit was found to be a protective factor, which had not been reported before. Smoking (a protective factor), family history, duration of pesticide exposure (in years) in farming and pesticide exposure during farming in women (both risk factors) have been reported previously. In multivariate analysis, current smoking reached borderline significance at the 5% level and the variables, years exposed to pesticides and family history were significant at the 10% level. By contrast with the common occurrence of polymorphism of the CYP2D6 gene (a gene involved with xenobiotic metabolism) in white people, it is very rare in China and is not thought to be a significant factor contributing to Parkinson’s disease in Chinese people.


Journal of the American Geriatrics Society | 2006

Delirium within Three Days of Stroke in a Cohort of Elderly Patients

Ai Zhen Sheng; Qing Shen; Dennis Cordato; Yun Yun Zhang; Daniel Kam Yin Chan

OBJECTIVES: To evaluate the incidence of stroke, risk factors for stroke, and outcomes in elderly stroke patients with delirium.


Neurology | 1997

The dopamine transporter gene and Parkinson's disease in a Chinese population

P. W. Leighton; D. G. Le Couteur; Chi Pui Pang; Sally J. McCann; Daniel Kam Yin Chan; L. K. Law; Richard Kay; Susan M. Pond; Jean Woo

We studied a variable number tandem repeat polymorphism within the dopamine transporter gene (DAT) for an association with Parkinsons disease in a Chinese population. Five alleles were detected, consisting of 6, 8, 9, 10, and 11 copies of the 40 base pair repeat sequence. The 10-copy allele was most common, accounting for 90% of alleles. There were no significant differences between the patients and the control subjects in the distribution frequencies of the alleles or genotypes. Therefore, this polymorphism is not associated with Parkinsons disease in Chinese populations.


Acta Neurologica Scandinavica | 2006

Stroke risk factor, pattern and outcome in patients with cancer

Y.-Y. Zhang; Daniel Kam Yin Chan; Dennis Cordato; Qing Shen; A.-Z. Sheng

Objective –  To investigate risk factors, stroke pattern and outcome in stroke patients with cancer.


Experimental Neurology | 2009

Anti-melanin antibodies are increased in sera in Parkinson's disease

Kay L. Double; Dominic B. Rowe; F.M. Carew-Jones; Michael Hayes; Daniel Kam Yin Chan; J. Blackie; Alastair Corbett; R. Joffe; Victor S.C. Fung; John G. Morris; Peter Riederer; Manfred Gerlach; Glenda M. Halliday

An increasing body of research suggests that a number of immune mechanisms play a role in degenerative pathways in Parkinsons disease (PD). In the current work we investigated a posited humoral immune response in this disorder. Sera from PD patients exhibited a significantly enhanced absorbance response on a novel ELISA for anti-melanin antibodies, compared to sera from age-matched control subjects. The enhanced ELISA absorbance response was specific for catecholamine-based melanins and was unrelated to antiparkinsonian dopaminergic medication. Further, the absorbance response was significantly and negatively correlated with disease duration. These data suggest that a specific humoral anti-melanin antibody response is present in PD and is more active in early disease. While the contribution of this novel immune response to the initiation and progression of this disorder is unclear, this finding supports the hypothesis that specific immune responses occurring in PD may respond to therapeutic interventions in this disorder.


Acta Neurologica Scandinavica | 2005

Prevalence of Parkinson's disease in Sydney

Daniel Kam Yin Chan; Dennis Cordato; Margaret A Karr; Bin Ong; H. Lei; J. Liu; W. T. Hung

Objective –  To examine the prevalence of Parkinsons disease (PD) in Bankstown, Sydney, using the same methodology as a previous study in Randwick, Sydney, Australia (1998–1999).


Australasian Journal on Ageing | 2006

The effects of water exercise on physical functioning in older people

Stephen R. Lord; Beth Matters; Rebecca J. St George; Margaret Thomas; Jeni Bindon; Daniel Kam Yin Chan; Anne Collings; Loraine Haren

Objective:  To determine whether a 22 week water exercise program can improve physical functioning in older people.


Acta Neurologica Scandinavica | 2006

Identifying the determinants of 1-year post-stroke outcomes in elderly patients

Qing Shen; Dennis Cordato; Daniel Kam Yin Chan; W. T. Hung; Margaret A Karr

Objectives –  To examine 12‐month outcomes and develop predictive models for outcomes in elderly stroke patients.


Journal of Neurology | 2000

The monoamine oxidase B gene GT repeat polymorphism and Parkinson's disease in a Chinese population

George D. Mellick; Daniel D. Buchanan; Peter A. Silburn; Daniel Kam Yin Chan; D. G. Le Couteur; L. K. Law; Jean Woo; Chi Pui Pang

Abstract Monoamine oxidase B (MAOB) metabolises dopamine and activates neurotoxins known to induce parkinsonism in humans and primates. Therefore the MAOB gene (MAOB; Xp15.21–4) is a candidate gene for Parkinson’s disease (PD). Longer length dinucleotide repeat sequences in a highly polymorphic GT repeat region of intron 2 of this gene showed an association with PD in an Australian cohort. We repeated this allele-association study in a population of 176 Chinese PD patients ¶(90 men, 86 women) and 203 age-matched controls (99 men, 104 women). Genomic DNA was extracted from venous blood and the polymerase chain reaction was used to amplify the appropriate regions of the MAOB gene. The length of each (GT) repeat sequence was determined by 5% polyacrylamide denaturing gel electrophoresis. There was no significant difference in allele frequencies of the (GT) repeat allelic variation between patients and controls (χ2 = 2.48; df = 5, P < 0.75). Therefore the longer length GT repeat alleles are not associated with PD in this Chinese population. Possible reasons for the discrepancy between Chinese and Australian populations include a different interaction between this genetic factor and environmental factors in the two populations and the possibility that the long length GT repeat alleles may represent a marker mutation, genetically linked to another susceptibility allele in whites but not in Chinese. Methodological differences in the ascertainment of cases and controls in this cohort could also explain the observed differences. Further study is required to determine whether the longer length GT repeat alleles are true susceptibility alleles in PD.

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Qing Shen

Bankstown Lidcombe Hospital

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Jean Woo

The Chinese University of Hong Kong

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Fintan O'Rourke

Bankstown Lidcombe Hospital

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Bin Ong

Bankstown Lidcombe Hospital

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Huong Van Nguyen

Bankstown Lidcombe Hospital

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Margaret A Karr

Bankstown Lidcombe Hospital

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Yinghua Xu

University of New South Wales

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Nady Braidy

University of New South Wales

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