Daniel Smolinski
University of Western Australia
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Publication
Featured researches published by Daniel Smolinski.
Journal of Musculoskeletal Research | 2004
C.W. Jones; A. Keogh; Daniel Smolinski; Jian Wu; Brett Kirk; Ming Zheng
Conventional histological assessment of tissue requires the removal of tissue from its physiological environment for pathological processing. In this study we report on the development and application of a laser scanning confocal arthroscope (LSCA) capable of in situ histological assessment by confocal microscopy. The knee joints of three euthanasied adult Merino sheep were imaged using the LSCA and a combination of fluorescent contrasting agents. LSCA images of various tissues were examined for common histological characteristics. The confocal histology images from the ovine knee acquired during the course of our study illustrated some of the major histological features of chondral and connective tissues. Our study demonstrates the efficacy of the LSCA for the histological assessment of the chondral and connective tissues of the ovine knee. The LSCA provides an easy and rapid method for assessing the in situ structure of cartilage, muscle, tendon, ligament, meniscus and synovium in their native and unaltered physiological environment. By obviating the need for mechanical biopsy, the LSCA provides a method for the non-destructive assessment of the chondral and connective tissues of the knee, and may be of great benefit in the investigation of orthopedic diseases or in the assessment of newly emerging cartilage repair techniques.
Journal of Musculoskeletal Research | 2004
C.W. Jones; Daniel Smolinski; J. P. Wu; Craig Willers; Karol Miller; T.B. Kirk; Minghao Zheng
The purpose of this study was to determine the effectiveness of a novel Laser Scanning Confocal Arthroscope (LSCA) for the morphological quantification of articular cartilage chondrocytes. Healthy and debrided regions of the knee articular cartilage of six (6) New Zealand White rabbits were imaged during open follow-up surgery. Quantitative morphological analysis of chondrocyte cell populations was performed and compared to known parameters. Optical histology images were compared to conventional histology of similar sites. Optical histology revealed viable cells in normal hyaline cartilage tissue and enabled the visualization of fibro-cartilage in defect tissue. Morphological analysis was able to characterize the in vivo two-dimensional equivalent-area-diameter of chondrocytes. Significant differences (P<0.05) were seen between the morphology of chondrocytes observed in optical and conventional histology. This study concludes that the LSCA is capable of illustrating the surface and sub-surface appearance of healthy and defect articular cartilage, thereby providing a non-destructive method for assessing cartilage condition in vivo. In this role the LSCA may find application in the investigation of cartilage pathologies or repair techniques.
Journal of Orthopaedic Research | 2008
C.W. Jones; Craig Willers; Angus Keogh; Daniel Smolinski; Daniel P. Fick; Piers Yates; T.B. Kirk; Ming Zheng
Progress in Histochemistry and Cytochemistry | 2005
C.W. Jones; Daniel Smolinski; A. Keogh; T.B. Kirk; M.H. Zheng
Osteoarthritis and Cartilage | 2007
C.W. Jones; Daniel Smolinski; Craig Willers; Piers Yates; A. Keogh; Daniel P. Fick; T.B. Kirk; M.H. Zheng
The Confocal Arthroscope as a Cartilage Optical Biopsy Tool | 2003
Daniel Smolinski; Jian Wu; C.W. Jones; M.H. Zheng; L.J. O'Hara; Karol Miller; Brett Kirk
Arthroscopy | 2008
Daniel Smolinski; C.W. Jones; Jian Ping Wu; Karol Miller; T.B. Kirk; Ming H. Zheng
Microscopy and Microanalysis | 2002
Daniel Smolinski
Orthopaedic Proceedings | 2005
Minghao Zheng; Craig Willers; D.J. Wood; C.W. Jones; Daniel Smolinski; J. P. Wu; Karol Miller; T.B. Kirk
The application and development of a handheld confocal system for surface analysis | 2004
Brett Kirk; Daniel Smolinski