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Dive into the research topics where Daniel Smolinski is active.

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Featured researches published by Daniel Smolinski.


Journal of Musculoskeletal Research | 2004

HISTOLOGICAL ASSESSMENT OF THE CHONDRAL AND CONNECTIVE TISSUES OF THE KNEE BY CONFOCAL ARTHROSCOPE

C.W. Jones; A. Keogh; Daniel Smolinski; Jian Wu; Brett Kirk; Ming Zheng

Conventional histological assessment of tissue requires the removal of tissue from its physiological environment for pathological processing. In this study we report on the development and application of a laser scanning confocal arthroscope (LSCA) capable of in situ histological assessment by confocal microscopy. The knee joints of three euthanasied adult Merino sheep were imaged using the LSCA and a combination of fluorescent contrasting agents. LSCA images of various tissues were examined for common histological characteristics. The confocal histology images from the ovine knee acquired during the course of our study illustrated some of the major histological features of chondral and connective tissues. Our study demonstrates the efficacy of the LSCA for the histological assessment of the chondral and connective tissues of the ovine knee. The LSCA provides an easy and rapid method for assessing the in situ structure of cartilage, muscle, tendon, ligament, meniscus and synovium in their native and unaltered physiological environment. By obviating the need for mechanical biopsy, the LSCA provides a method for the non-destructive assessment of the chondral and connective tissues of the knee, and may be of great benefit in the investigation of orthopedic diseases or in the assessment of newly emerging cartilage repair techniques.


Journal of Musculoskeletal Research | 2004

Quantification of Chondrocyte Morphology by Confocal Arthroscopy

C.W. Jones; Daniel Smolinski; J. P. Wu; Craig Willers; Karol Miller; T.B. Kirk; Minghao Zheng

The purpose of this study was to determine the effectiveness of a novel Laser Scanning Confocal Arthroscope (LSCA) for the morphological quantification of articular cartilage chondrocytes. Healthy and debrided regions of the knee articular cartilage of six (6) New Zealand White rabbits were imaged during open follow-up surgery. Quantitative morphological analysis of chondrocyte cell populations was performed and compared to known parameters. Optical histology images were compared to conventional histology of similar sites. Optical histology revealed viable cells in normal hyaline cartilage tissue and enabled the visualization of fibro-cartilage in defect tissue. Morphological analysis was able to characterize the in vivo two-dimensional equivalent-area-diameter of chondrocytes. Significant differences (P<0.05) were seen between the morphology of chondrocytes observed in optical and conventional histology. This study concludes that the LSCA is capable of illustrating the surface and sub-surface appearance of healthy and defect articular cartilage, thereby providing a non-destructive method for assessing cartilage condition in vivo. In this role the LSCA may find application in the investigation of cartilage pathologies or repair techniques.


Journal of Orthopaedic Research | 2008

Matrix-induced autologous chondrocyte implantation in sheep: objective assessments including confocal arthroscopy

C.W. Jones; Craig Willers; Angus Keogh; Daniel Smolinski; Daniel P. Fick; Piers Yates; T.B. Kirk; Ming Zheng


Progress in Histochemistry and Cytochemistry | 2005

Confocal laser scanning microscopy in orthopaedic research.

C.W. Jones; Daniel Smolinski; A. Keogh; T.B. Kirk; M.H. Zheng


Osteoarthritis and Cartilage | 2007

Laser scanning confocal arthroscopy of a fresh cadaveric knee joint

C.W. Jones; Daniel Smolinski; Craig Willers; Piers Yates; A. Keogh; Daniel P. Fick; T.B. Kirk; M.H. Zheng


The Confocal Arthroscope as a Cartilage Optical Biopsy Tool | 2003

The Confocal Arthroscope as a Cartilage Optical Biopsy Tool

Daniel Smolinski; Jian Wu; C.W. Jones; M.H. Zheng; L.J. O'Hara; Karol Miller; Brett Kirk


Arthroscopy | 2008

Confocal arthroscopic assessment of osteoarthritis in situ.

Daniel Smolinski; C.W. Jones; Jian Ping Wu; Karol Miller; T.B. Kirk; Ming H. Zheng


Microscopy and Microanalysis | 2002

Confocal Arthroscope Development For in vivo Knee Joint Diagnosis

Daniel Smolinski


Orthopaedic Proceedings | 2005

DEVELOPMENT OF A CONFOCAL ARTHROSCOPE FOR NON-INVASIVE HISTOLOGICAL ASSESSMENT OF CARTILAGE

Minghao Zheng; Craig Willers; D.J. Wood; C.W. Jones; Daniel Smolinski; J. P. Wu; Karol Miller; T.B. Kirk


The application and development of a handheld confocal system for surface analysis | 2004

The application and development of a handheld confocal system for surface analysis

Brett Kirk; Daniel Smolinski

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C.W. Jones

University of Western Australia

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Karol Miller

University of Western Australia

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M.H. Zheng

University of Western Australia

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Craig Willers

University of Western Australia

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A. Keogh

University of Western Australia

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Daniel P. Fick

University of Western Australia

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J. P. Wu

University of Western Australia

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Minghao Zheng

University of Western Australia

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