Daniela Fattori

A New Method for Chemoselective Conjugation of Unprotected Peptides to Dauno- and Doxorubicin

A new approach for chemoselective ligation of peptides to dauno- and doxorubicin through an oxime bond is presented. The method does not require protecting groups on the peptide moiety.

A practical approach to the synthesis of hairpin polyamide-peptide conjugates through the use of a safety-catch linker.

Hairpin polyamides are high-affinity, sequence selective DNA binders. The use of a safety-catch linker for the solid phase synthesis of hairpin polyamides allows for easy preparation of derivatives ready for chemoselective ligation with unprotected peptides. Examples of ligations reported include thioether bond formation and thioester-mediated amide bond formation (Native Chemical Ligation).

Prime Site Binding Inhibitors of the Hepatitis C Virus NS3/4A Serine Protease

Infection by hepatitis C virus (HCV) is a leading cause of cirrhosis and liver cancer. Much effort for a therapy is currently devoted to the search of inhibitors of the serine protease NS3/4A, which is required for maturation of viral polyprotein.