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Dive into the research topics where Daniele Morosetti is active.

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Featured researches published by Daniele Morosetti.


Catheterization and Cardiovascular Interventions | 2013

Randomized control study of the outback LTD reentry catheter versus manual reentry for the treatment of chronic total occlusions in the superficial femoral artery

Roberto Gandini; Sebastiano Fabiano; Sergio Spano; Tommaso Volpi; Daniele Morosetti; Antonio Chiaravalloti; Giovanni Nano; Giovanni Simonetti

To assess the efficacy and safety of the Outback device in patients with a chronic total occlusion (CTO) of the superficial femoral artery and evaluate its impact on fluoroscopy and procedural times.


Journal of Endovascular Therapy | 2014

Treatment of type II endoleak after endovascular aneurysm repair: the role of selective vs. nonselective transcaval embolization.

Roberto Gandini; Marcello Chiocchi; Giorgio Loreni; Costantino Del Giudice; Daniele Morosetti; Antonio Chiaravalloti; Giovanni Simonetti

Purpose To assess the technical and midterm results in the treatment of type II endoleaks comparing nonselective (nTCE) vs. selective (sTCE) transcaval embolization. Methods During a 4-year period, 26 patients (18 men; median age 73 years, range 68–78) underwent direct transcaval aneurysm puncture followed by embolization of the sac (nTCE, n=9) or of the feeding vessels (sTCE, n=17). Intrasac pressure was recorded immediately after aneurysm sac puncture and at the end of the procedure. Technical success was defined as successful deployment of embolization material in the sac or in the feeding vessel. Clinical success was defined as absence of endoleak with stabilization of the sac on follow-up CTA. Results Technical success was 100% in the 9 patients treated with nTCE. Mean intrasac pressures before and after nTCE were 58.6±18.4 (range 51–105) and 6.5±1.2 mmHg (range 4–9), respectively. Over a mean 25.9±11.0 months of follow-up, 4 patients developed recurrent endoleak at a mean 9.7±3.9 months. Three patients were subsequently treated with sTCE, while the last patient underwent emergency surgery for aneurysm rupture due to an enlarging sac 5 months after nTCE. The 20 patients in the sTCE group had a successful procedure with no recurrence in a follow-up of 24.1±7.2 months. Mean intrasac pressure was reduced after sTCE from 63.6±15.2 mmHg (range 43–120) to 7.8±2.3 mmHg (range 5–12). Conclusion The selective TCE approach appears to be a feasible and effective primary therapeutic option for treating type II endoleak.


Journal of The Saudi Heart Association | 2015

Congenital left ventricular diverticulum: Multimodality imaging evaluation and literature review

Andrea Romagnoli; Aurora Ricci; Daniele Morosetti; Armando Fusco; Daniele Citraro; Giovanni Simonetti

Congenital ventricular diverticulum is a rare cardiac malformation. We present the case of a 57-year-old man who underwent cardiac catheterization for suspected unstable angina. No coronary artery disease was diagnosed and a left ventricular diverticulum was incidentally found. Coronary CT and cardiac MRI were performed in order to confirm the diagnosis of a muscular type diverticulum and to exclude a post-ischemic aneurysm.


Clinical Neurology and Neurosurgery | 2013

Intracranial atheromatous disease treatment with the Wingspan stent system: Evaluation of clinical, procedural outcome and restenosis rate in a single-center series of 21 consecutive patients with acute and mid-term results

Roberto Gandini; Antonio Chiaravalloti; Enrico Pampana; Francesco Massari; Daniele Morosetti; Sergio Spano; Giorgio Loreni; Giovanni Simonetti

BACKGROUND Intracranial atherosclerosis may be the underlying pathology in up to 15% of ischemic strokes, but may account for about 40% of strokes in some populations. After an ischemic event determined by intracranial atherosclerosis, patients have a 12% annual risk of stroke recurrence, mostly during the first year. OBJECTIVE To evaluate procedural safety, clinical outcome and restenosis rate of Wingspan stent placement. METHODS Twenty-one caucasoid patients were enrolled. Target patients were affected by high-grade, symptomatic, intracranial atherosclerotic lesions, were on antithrombotic therapy and at high stroke risk. All patients were treated with the Wingspan stent system. RESULTS Technical success resulted 100%, with all target lesions being reduced to <50%. No stroke or death were observed at 30. The mean percent of stenosis was reduced from a middle value of 84% to a middle value of 17% after stent placement. Medium follow-up was 19.5months (range 6-36months). No stroke or death occurred in any patient. None of the patients presented a <50% stent patency rate at follow-up. CONCLUSIONS The short-term results and follow up analysis provide evidence demonstrating the safety of the Wingspan system when used in high-risk patient population. Due to concerns regarding long-term stent patency and ischemic events occurrence emerged from clinical trials such as the SAMMPRIS, intracranial angioplasty and stent with the Wingspan system should be considered only for high risk patients in which it may be considered the only viable therapeutic option.


Journal of the American Geriatrics Society | 2017

Efficacy and Safety of Mechanical Thrombectomy in Older Adults with Acute Ischemic Stoke

Fabrizio Sallustio; Giacomo Koch; Caterina Motta; Marina Diomedi; Fana Alemseged; Vittoria Carla D'Agostino; Simone Napolitano; Domenico Samà; Alessandro Davoli; Daniel Konda; Daniele Morosetti; Enrico Pampana; Roberto Floris; Roberto Gandini

To evaluate the safety and efficacy of endovascular therapy in elderly adults treated for acute ischemic stroke.


Journal of Applied Clinical Medical Physics | 2015

Patient skin dose measurements using a cable free system MOSFETs based in fluoroscopically guided percutaneous vertebroplasty, percutaneous disc decompression, radiofrequency medial branch neurolysis, and endovascular critical limb ischemia

M.D. Falco; Salvatore Masala; Matteo Stefanini; Roberto Fiori; Roberto Gandini; Paolo Bagalà; Daniele Morosetti; Eros Calabria; Alessia Tonnetti; G. Verona-Rinati; Riccardo Santoni; Giovanni Simonetti

The purpose of this work has been to dosimetrically investigate four fluoroscopically guided interventions: the percutaneous vertebroplasty (PVP), the percutaneous disc decompression (PDD), the radiofrequency medial branch neurolysis (RF) (hereafter named spine procedures), and the endovascular treatment for the critical limb ischemia (CLI). The X‐ray equipment used was a Philips Integris Allura Xper FD20 imaging system provided with a dose‐area product (DAP) meter. The parameters investigated were: maximum skin dose (MSD), air kerma (Ka,r), DAP, and fluoroscopy time (FT). In order to measure the maximum skin dose, we employed a system based on MOSFET detectors. Before using the system on patients, a calibration factor Fc and correction factors for energy (CkV) and field size (CFD) dependence were determined. Ka,r, DAP, and FT were extrapolated from the X‐ray equipment. The analysis was carried out on 40 patients, 10 for each procedure. The average fluoroscopy time and DAP values were compared with the reference levels (RLs) proposed in literature. Finally, the correlations between MSD, FT, Ka,r, and DAP values, as well as between DAP and FT values, were studied in terms of Pearsons product‐moment coefficients for spine procedures only. An Fc value of 0.20 and a very low dependence of CFD on field size were found. A third‐order polynomial function was chosen for CkV. The mean values of MSD ranged from 2.3 to 10.8 cGy for CLI and PVP, respectively. For these procedures, the DAP and FT values were within the proposed RL values. The statistical analysis showed little correlation between the investigated parameters. The interventional procedures investigated were found to be both safe with regard to deterministic effects and optimized for stochastic ones. In the spine procedures, the observed correlations indicated that the estimation of MSD from Ka,r or DAP was not accurate and a direct measure of MSD is therefore recommended. PACS number: 87


Journal of NeuroInterventional Surgery | 2018

Mechanical thrombectomy of acute ischemic stroke with a new intermediate aspiration catheter: preliminary results

Fabrizio Sallustio; Enrico Pampana; Alessandro Davoli; Stefano Merolla; Giacomo Koch; Fana Alemseged; Marta Panella; Vittoria Carla D’Agostino; Francesco Mori; Daniele Morosetti; Daniel Konda; Sebastiano Fabiano; Marina Diomedi; Roberto Gandini

Background and purpose To report clinical and procedural outcomes of acute ischemic stroke patients after endovascular treatment with the new thromboaspiration catheter AXS Catalyst 6. Methods Patients with anterior and posterior circulation stroke were selected. Successful reperfusion defined as a Thrombolysis in Cerebral Infarction (TICI) score ≥2 b and 3-month functional independence defined as a modified Rankin Scale (mRS) ≤2 were the main efficacy outcomes. Symptomatic intracranial hemorrhage and mortality were the main safety outcomes. Results 107 patients were suitable for analysis. Mean age was 73.18±12.62 year and median baseline NIHSS was 17 (range: 3–32). The most frequent site of occlusion was the middle cerebral artery (MCA) (60.7%). 76.6% of patients were treated with AXS Catalyst 6 alone without the need for rescue devices or thromboaspiration catheters. Successful reperfusion was achieved in 84.1%, functional independence in 47.6%, symptomatic intracranial hemorrhage occurred in 3.7%, and mortality in 21.4%. Conclusions Endovascular treatment with AXS Catalyst 6 proved to be safe, technically feasible, and effective. Comparison analyses with other devices for mechanical thrombectomy are needed.


Journal of Cardiovascular Medicine | 2013

Intravascular ultrasound assisted carotid artery stenting: randomized controlled trial. Preliminary results on 60 patients.

Marcello Chiocchi; Daniele Morosetti; Antonio Chiaravalloti; Giorgio Loreni; Roberto Gandini; Giovanni Simonetti

Aims The primary aim is the evaluation of the usefulness of intravascular ultrasound (IVUS) in the identification of otherwise unnoticed complications during carotid stenting. The secondary aim is the evaluation of the impact of IVUS assistance in the procedural outcomes and long-term patency rates of carotid artery stenting. Materials and methods Sixty patients who underwent carotid artery stenting (CAS) during a 14-month period were evaluated prospectively. Thirty patients (50%) underwent IVUS assisted CAS, 30 patients (50%) underwent CAS using angiography as the unique diagnostic tool. All patients were enrolled through a primary duplex ultrasound evaluation; as a secondary evaluation, 54 patients (90%) underwent a preprocedural magnetic resonance angiography, whereas six patients (10%) underwent computed tomography-angiography. Patients with preocclusive stenoses (>85%) were excluded. Mean follow-up was 23 W 5.3 months. Results No periprocedural or late complications were observed. No statistical significance was observed in long-term stent patency between the two groups. Mean procedural time length of IVUS-assisted procedures was 10.3 W 5 min longer than non-IVUS-assisted procedures. Virtual histology (VH) IVUS evaluation of plaque morphology led to a different stent choice in three patients. In two cases, the IVUS assessment revealed a suboptimal stent deployment, solved by angioplasty; in one patient VH-IVUS detected plaque protrusion through stent cells, immediately treated by manual aspiration. Conclusions Though not recommended as a routine intraprocedural evaluation, IVUS may be useful for a real-time CAS control when treating challenging plaques, such as ‘soft’ or lipidic ones or those prone to rupture, or whenever an intraprocedural morphologic evaluation is required for the appropriate stent choice, or when higher embolic risk is evaluated.


Journal of Neurology | 2018

Effect of mechanical thrombectomy alone or in combination with intravenous thrombolysis for acute ischemic stroke

Fabrizio Sallustio; Giacomo Koch; Fana Alemseged; Daniel Konda; Sebastiano Fabiano; Enrico Pampana; Daniele Morosetti; Roberto Gandini; Marina Diomedi

Objective and designWhether combining intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) is superior to mechanical thrombectomy alone for large vessel occlusion acute ischemic stroke is still uncertain. Our aim was to compare the safety and the efficacy of these two therapeutic strategies.MaterialsPatients with acute ischemic stroke secondary to anterior circulation large vessel occlusion.MethodsA retrospective analysis was conducted. IVT was performed with full dose recombinant tissue plasminogen activator. MT alone was performed only if intravenous thrombolysis was contraindicated. Primary outcomes were successful reperfusion, 3-month functional independence, symptomatic intracranial hemorrhage (sICH), and 3-month mortality.Results325 patients were analyzed: 193 treated with combined IVT and MT, 132 with MT alone. The combined treatment group showed higher systolic blood pressure (140 [80–230] vs 150 [90–220]; p = 0.036), rate of good collaterals (55.9% vs 67%; p = 0.03), use of aspiration devices (68.2% vs 79.3%; p = 0.003) and shorter onset-to-reperfusion time (300 [90–845] vs 288 [141–435]; p = 0.008). No differences were found in the efficacy and safety outcomes except for mortality which was lower in the combined treatment group (36.4% vs 25.4%; p = 0.02). However, after multivariable analysis combined treatment was not associated with lower mortality (OR 1.47; 95% CI 0.73–2.96; p = 0.3).ConclusionsOur study suggests that mechanical thrombectomy alone is effective and safe in patients with contraindications to intravenous thrombolysis. Preceding use of IVT in eligible patients was not associated with increased harm or benefit. Randomized controlled trials are needed to clarify whether intravenous thrombolysis before mechanical thrombectomy is associated with additional benefit.


Journal of NeuroInterventional Surgery | 2017

Pretreatment predictors of malignant evolution in patients with ischemic stroke undergoing mechanical thrombectomy

Alessandro Davoli; Caterina Motta; Giacomo Koch; Marina Diomedi; Simone Napolitano; Angela Giordano; Marta Panella; Daniele Morosetti; Sebastiano Fabiano; Roberto Floris; Roberto Gandini; Fabrizio Sallustio

Background Few data exist on malignant middle cerebral artery infarction (MMI) among patients with acute ischemic stroke (AIS) after endovascular treatment (ET). Numerous predictors of MMI evolution have been proposed, but a comprehensive research of patients undergoing ET has never been performed. Our purpose was to find a practical model to determine robust predictors of MMI in patients undergoing ET. Methods Patients from a prospective single-center database with AIS secondary to large intracranial vessel occlusion of the anterior circulation, treated with ET, were retrospectively analyzed. We investigated demographic, clinical, and radiological data. Multivariate regression analysis was used to identify clinical and imaging predictors of MMI. Results 98 patients were included in the analysis, 35 of whom developed MMI (35.7%). No differences in the rate of successful reperfusion and time from stroke onset to reperfusion were found between the MMI and non-MMI groups. The following parameters were identified as independent predictors of MMI: systolic blood pressure (SBP) on admission (p=0.008), blood glucose (BG) on admission (p=0.024), and the CTangiography (CTA) Alberta Stroke Program Early CT Score (ASPECTS) (p=0.001). A scoreof ≤5 in CTA ASPECTS was the best cut-off to predict MMI evolution (sensitivity 46%; specificity 97%; positive predictive value 78%; negative predictive value 65%). Conclusions in our study a clinical and radiological features-based model was strongly predictive of MMI evolution in AIS. High SBP and BG on admission and, especially, a CTA ASPECTS ≤5 may help to make decisions quickly, regardless of time to treatment and successful reperfusion.

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Roberto Gandini

University of Rome Tor Vergata

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Giovanni Simonetti

University of Rome Tor Vergata

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Antonio Chiaravalloti

University of Rome Tor Vergata

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Sebastiano Fabiano

University of Rome Tor Vergata

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Daniel Konda

University of Rome Tor Vergata

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Enrico Pampana

University of Rome Tor Vergata

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Fabrizio Sallustio

University of Rome Tor Vergata

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Giacomo Koch

University of Rome Tor Vergata

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Marcello Chiocchi

University of Rome Tor Vergata

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Marina Diomedi

University of Rome Tor Vergata

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