Daniele Zangla

Effects of exercise training on airway responsiveness and airway cells in healthy subjects

Airway responsiveness to methacholine (Mch) in the absence of deep inspirations (DIs) is lower in athletes compared with sedentary individuals. In this prospective study, we tested the hypothesis that a training exercise program reduces the bronchoconstrictive effect of Mch. Ten healthy sedentary subjects (M/F: 3/7; mean + or - SD age: 22 + or - 3 yr) entered a 10-wk indoor rowing exercise program on rowing ergometer and underwent Mch bronchoprovocation in the absence of DIs at baseline, at weeks 5 and 10, as well as 4-6 wk after the training program was completed. Exercise-induced changes on airway cells and markers of airway inflammation were also assessed by sputum induction and venous blood samples. Mean power output during the 1,000 m test was 169 + or - 49 W/stroke at baseline, 174 + or - 49 W/stroke at 5 wk, and 200 + or - 60 W/stroke at 10 wk of training (P < 0.05). The median Mch dose used at baseline was 50 mg/ml (range 25-75 mg/ml) and remained constant per study design. At the pretraining evaluation, the percent reduction in the primary outcome, the inspiratory vital capacity (IVC) after inhalation of Mch in the absence of DIs was 31 +/- 13%; at week 5, the Mch-induced reduction in IVC was 22 + or - 19%, P = 0.01, and it further decreased to 15 + or - 11% at week 10 (P = 0.0008). The percent fall in IVC 4-6 wk after the end of training was 15 + or - 11% (P = 0.87 vs. end of training). Changes in airway cells were not associated with changes in airway responsiveness. Our data show that a course of exercise training can attenuate airway responsiveness against Mch inhaled in the absence of DIs in healthy subjects and suggest that a sedentary lifestyle may favor development of airways hyperresponsiveness.

Is karate effective in improving postural control

Background: Performing complex motor skills, such as the ones performed by karate athletes, requires a great sense of balance. Because the posturo-kinetic performance seems to be improved by sport practice, especially by sports involving a lot of posturokinetic activities, the aim of this review was to critically analyse the scientific literature in order to appraise whether any positive correlation between karate and improved postural control is scientifically supported. Material/Methods: The online search engines Scirus and Medline were used for generating the data. A comprehensive literature search was conducted based on the following keywords: “karate”, “postural control” and “body sway”. Results were collected and filtered manually. Results: Four articles were identified related to karate practice and postural control, covering a period between 1998 and 2009. Although different experimental approaches were used to investigate this concept, overall the results of these studies confirm the effectiveness of karate in improving postural control. Conclusions: Practicing karate seems to elicit long term improvements in postural control. However, a much deeper approach to this fighting sport, which would take into account its technical specificities (e.g. kata & kumite), is required in order to increase our understanding of the posture-kinetic impact of this relatively unexplored sport activity.

Effects of exercise training on airway closure in asthmatics

We previously reported that responsiveness to methacholine (Mch) in the absence of deep inspiration (DI) decreased in healthy subjects after a short course of exercise training. We assessed whether a similar beneficial effect of exercise on airway responsiveness could occur in asthmatics. Nine patients (male/female: 3/6; mean age ± SD: 24 ± 2 yr) with mild untreated asthma [forced expiratory volume in 1 s (FEV(1)): 100 ± 7.4% pred; FEV(1)/vital capacity (VC): 90 ± 6.5%] underwent a series of single-dose Mch bronchoprovocations in the absence of DI in the course of a 10-wk training rowing program (6 h/wk of submaximal and maximal exercise), at baseline (week 0), and at week 5 and 10. The single-dose Mch was established as the dose able to induce ≥ 15% reduction in inspiratory vital capacity (IVC) and was administered to each subject at every challenge occasion. Five asthmatics (male/female: 1/4; mean age ± SD: 26 ± 3 yr) with similar baseline lung function (FEV(1): 102 ± 7.0% predicted; FEV(1)/VC: 83 ± 6.0%; P = 0.57 and P = 0.06, respectively) not participating in the exercise training program served as controls. In the trained group, the Mch-induced reduction in IVC from baseline was 22 ± 10% at week 0, 13 ± 11% at week 5 (P = 0.03), and 11 ± 8% at week 10 (P = 0.028). The Mch-induced reduction in FEV(1) did not change with exercise (P = 0.69). The reduction in responsiveness induced by exercise was of the same magnitude of that previously obtained in healthy subjects (50% with respect to pretraining). Conversely, Mch-induced reduction in IVC in controls remained unchanged after 10 wk (%reduction IVC at baseline: 21 ± 20%; after 10 wk: 29 ± 14%; P = 0.28). This study indicates that a short course of physical training is capable of reducing airway responsiveness in mild asthmatics.

Visuospatial attention lateralization in volleyball players and in rowers.

In the present study, differences in visuospatial attention lateralization were evaluated in athletes engaged in open- compared to closed-skill sports and sedentary nonathletes. 23 volleyball players (open skill; Italian national level and regional level), 10 rowers (closed skill, Italian national level), and 23 sedentary participants responded to a computerized line-length judgment task. Five lines, differing in the length of their right and left segments, were randomly presented; the respondent made a forced-choice decision about the respective length of the two segments. Volleyball players responded significantly faster; those at the higher competitive level were also more accurate, making a statistically significantly lower number of leftward errors as compared with rowers and controls. If such responses are due to training rather than self-selection of ability, then the results may suggest the possibility of changing the distribution of visuospatial attention by training in open-skill sports.

Relationship between wingate cycle test and 2000m rowing ergometer performance in youth athletes

During 2000m indoor rowing performances, the estimated aerobic and anaerobic contribution are 65-75% and 25-35%, respectively2. In considering that anaerobic power could be an important predictor of performance1, the aim of this study was to analyse the relationship between the power outputs during a Wingate anaerobic test (WAnT) on a cycling ergometer and a 2000m rowing ergometer performance in young rowers. In two separate days, 11 young (14.9±1.1yrs) male rowers performed a 2000m indoor rowing ergometer performance and a 30s WAnT on a cycling ergometer. WAnT peak power (PP) and mean power (MP), and 2000m time indoor rowing performance (t2000) were collected. Moreover, PP and MP were normalized with respect to body mass. Pearson correlation coefficients (r) were used to determine the association between t2000 and absolute and normalized PP and MP values. Absolute PP and MP were 888.1±133.2W and 548.5±74.4W, respectively. The relative picture for normalized values was 13.4±1.5 W·kg-1 and 8.2±0.6 W·kg-1. High associations emerged between t2000 (431.5±19.5s) and absolute PP (r=-0.900, P= 0.05) values, whereas no significant relationship was observed for normalized PP (r=-0.585, P=0.058) and AP (r=-0.561, P=0.072) values. These findings indicate that PP and MP could be considered significant predictors of 2000m rowing ergometer performances, substantiating also the relevance of the anaerobic energy pathways to the 2,000m rowing performance.

Effects of Exercise on the Airways

Maria R. Bonsignore1,4, Nicola Scichilone1, Laura Chimenti1, Roberta Santagata1, Daniele Zangla2 and Giuseppe Morici3,4 1Biomedical Department of Internal and Specialistic Medicine (DiBiMIS), Section of Pneumology, 2Department of Motor Sciences (DISMOT), 3Department of Experiental Biomedicine and Clinical Neurosciences (BIONEC), University of Palermo, 4Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council, Palermo Italy