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Dive into the research topics where Dante Schiavo is active.

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Featured researches published by Dante Schiavo.


Chest | 2013

Influence of interstitial lung disease on outcome in systemic sclerosis: A population-based historical cohort study

Philippe R. Bauer; Dante Schiavo; Thomas Osborn; David L. Levin; Jennifer L. St. Sauver; Andrew C. Hanson; Darrell R. Schroeder; Jay H. Ryu

BACKGROUND Interstitial lung disease (ILD) is a frequent complication of systemic sclerosis (SSc) and a major cause of SSc-related deaths. This study aimed to determine the influence of ILD on SSc in a population-based historical cohort study. The hypothesis was that patients with SSc who develop ILD have increased morbidity and mortality when compared with patients with SSc without ILD. METHODS Using the record linkage system of the Rochester Epidemiology Project in Olmsted County, Minnesota, this study identified the incidence of SSc between 1980 and 2010 and point prevalence on December 31, 2010 and determined the progression of organ involvement and its influence on outcome. RESULTS During the 30-year interval, we identified 64 incident cases of SSc: 57 women and seven men, median age 49.1 years (interquartile range [IQR], 39.8-67.6 years). There were 43 prevalent cases. ILD occurred in 19 cases, usually after the diagnosis of SSc (median, 2 years; IQR, 0-10 years), with only three cases occurring 6 to 24 months beforehand. Pulmonary arterial hypertension (PAH) was diagnosed in 14 cases, heart failure in 27 cases, and chronic kidney disease (CKD) in 21 cases. Seventeen patients died during the study period, with a median survival time after diagnosis of 22.9 years. ILD, PAH, and CKD were associated with an increased risk of death. CONCLUSIONS The incidence of ILD associated with SSc was relatively low in this population-based cohort. ILD appeared to be a contributing factor to mortality. Other factors, including age, PAH, and CKD, were also associated with poor outcome.


Journal of bronchology & interventional pulmonology | 2017

Methylene Blue for Bronchopleural Fistula Localization

Kenneth Sakata; Faria Nasim; Dante Schiavo; Darlene R. Nelson; Ryan Kern; John J. Mullon

A bronchopleural fistula (BPF) is a communication between the pleural space and the bronchial tree. BPFs are challenging to diagnose and are associated with a high morbidity and mortality. Sequential balloon occlusion is commonly used for localization of a BPF. We describe our experience with 4 cases of successful localization of the BPF by instillation of methylene blue into the pleural space through a pigtail catheter, with simultaneous bronchoscopic visualization of dye in the tracheobronchial tree. Two patients were treated with endobronchial valves and 3 had a surgical thoracic muscle flap placed.


Journal of bronchology & interventional pulmonology | 2016

Pulmonary Parenchymal Lymphoma Diagnosed by Bronchoscopic Cryoprobe Lung Biopsy.

Dante Schiavo; Cassandra Batzlaff; Fabien Maldonado

A 51-year-old man presented with progressively worsening lung infiltrates and respiratory failure. Extensive investigations including bronchoscopy with bronchoalveolar lavage and conventional transbronchial forceps biopsies failed to establish the diagnosis. After transfer to our institution, he underwent repeat bronchoscopy with transbronchial cryobiopsy, which provided large, high-quality biopsy specimens establishing the diagnosis of parenchymal diffuse large B-cell lymphoma.


Journal of Medical Case Reports | 2014

Fatal fulminant necrotizing pneumonia: A case report

Dante Schiavo; Philippe R. Bauer; Vivek N. Iyer; Jay H. Ryu

IntroductionHere we present the case of a patient with fatal pulmonary histoplasmosis who presented with extensive necrotizing and cavitating pneumonia. To the best of our knowledge, this case report is the first to describe this presentation in a patient with no known immunosuppression.Case presentationA 45-year-old Caucasian woman, a smoker from southeastern Minnesota, presented to our hospital with progressive dyspnea, fatigue and weight loss over the course of several months. Her medical history included type 2 diabetes mellitus, systemic hypertension and chronic opioid use for back pain. She did not have any recent travel history, and she had no unusual hobbies or risk factors for human immunodeficiency virus. When she was admitted to our intensive care unit, she was in hypoxic respiratory failure, thus we intubated her and placed her on mechanical ventilation. A computed tomographic scan of the chest revealed extensive areas of pulmonary necrosis with diffuse bilateral cavitation and lung destruction, which were especially prominent in the upper and middle lung fields. Bronchoalveolar lavage confirmed growth of Histoplasma capsulatum as the sole isolated pathogen. No other infectious agents were identified in blood, bronchoalveolar lavage, sputum or urine samples. Her condition worsened over the next 24 to 48 hours, with progressive multi-organ failure in spite of aggressive antibiotic and antifungal therapy. Her family elected to withdraw supportive care, and she died shortly thereafter.ConclusionThis case demonstrates a novel manifestation of histoplasmosis associated with extensive lung necrosis and cavitation. This report is of particular interest to pulmonologists and intensivists and underscores the importance of maintaining suspicion for mycotic disease in patients who have atypical presentations but live in an endemic area.


Respirology | 2018

Risk factors for pleural effusion recurrence in patients with malignancy: Pleural effusion recurrence

Horiana B. Grosu; Sofia Molina; Roberto F. Casal; Juhee Song; Liang Li; Javier Diaz-Mendoza; Chakravarthy Reddy; Lonny Yarmus; Dante Schiavo; Michael Simoff; Jared Johnstun; Abu-Awwad Raid; David Feller-Kopman; Hans J. Lee; Sarina K. Sahetya; Finbar Foley; Fabien Maldonado; Xin Tian; Laila Noor; Russell Miller; Lakshmi Mudambi; Timothy Saettele; Macarena Vial-Rodriguez; Gerogie A. Eapen; David E. Ost

The main purpose of treatment in patients with malignant pleural effusion (MPE) is symptom palliation. Currently, patients undergo repeat thoracenteses prior to receiving a definitive procedure as clinicians are not aware of the risk factors associated with fluid recurrence. The primary objective of this study was to identify risk factors associated with recurrent symptomatic MPE.


Chest | 2018

Comparison of Programmed Death Ligand-1 Immunohistochemical Staining Between Endobronchial Ultrasound Transbronchial Needle Aspiration and Resected Lung Cancer Specimens

Kenneth Sakata; David E. Midthun; John J. Mullon; Ryan M. Kern; Darlene R. Nelson; Eric S. Edell; Dante Schiavo; James R. Jett; Marie Christine Aubry

Background In advanced non‐small cell lung cancer (NSCLC), small biopsy specimens from endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) are often the only available material from cancer tissue for the analysis of programmed death ligand‐1 (PD‐L1) expression. We aim to assess the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of PD‐L1 expression at ≥ 1% and ≥ 50% on EBUS‐TBNA samples compared with their corresponding surgically resected tumor. Methods We retrospectively reviewed all patients who underwent EBUS‐TBNA followed by surgical resection of NSCLC between July 2006 and September 2016. Demographic information and periprocedural/surgical data were collected. The archived specimens were retrieved and assessed for PD‐L1. A positive PD‐L1 stain was defined using two separate cutoff points: ≥ 1% and ≥ 50% of tumor cell positivity. EBUS‐TBNA aspirates were compared with the surgically resected specimen to calculate the sensitivity, specificity, PPV, and NPV. Results Sixty‐one patients were included. For PD‐L1 ≥ 1%, the sensitivity, specificity, PPV, and NPV were 72%, 100%, 100%, and 80%, respectively. For PD‐L1 ≥ 50%, the sensitivity, specificity, PPV, and NPV were 47%, 93%, 70%, and 84%, respectively. The concordance rates for PD‐L1 ≥ 1% and ≥ 50% were 87% and 82%, respectively. Conclusions A PD‐L1 cutoff of ≥ 1% on EBUS‐TBNA has a strong correlation with resected tumor specimen. For PD‐L1 ≥ 50%, there is a significant decrease in the sensitivity and PPV of EBUS‐TBNA specimen when compared with resected tumor. When analyzing for PD‐L1 expression using a cutoff of ≥ 50%, EBUS‐TBNA specimens may misclassify the status of PD‐L1.


Journal of Hospital Medicine | 2015

The

A. Scott Keller; Dante Schiavo; Majken T. Wingo; Floranne C. Ernste; William Sanchez

A 40-year-old Sudanese man was admitted due to worsening abdominal pain with recurrent ascites. He had a history of hepatitis B (HBV) infection and diabetes. He previously drank 3 beers per day on the weekends, but he had not consumed alcohol in over a year. He was born in Sudan but lived in Egypt most of his adult life; he immigrated to the United States 6 years previously. He was hospitalized out of state 9 months ago for “a swollen abdomen” and underwent an exploratory laparotomy that reportedly was unremarkable except for ascites.


Chest | 2017

64,000 question.

Faria Nasim; Kenneth Sakata; Dante Schiavo; Darlene R. Nelson; Ryan Kern; John J. Mullon


Chest | 2017

Localizing Bronchopleural Fistula With Methylene Blue

Xavier Fonseca Fuentes; Govind Pandompatam; Dante Schiavo


Archive | 2014

Frequency and Outcomes of Bronchoscopy-Related Pneumothorax

Dante Schiavo; Philippe R. Bauer; Vivek N. Iyer; Jay H. Ryu

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Ryan Kern

University of California

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