Darko Capak
University of Zagreb
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Featured researches published by Darko Capak.
Veterinary Record | 2005
Dražen Vnuk; Tomislav Babić; Marko Stejskal; Darko Capak; Ivica Harapin; Boris Pirkić
The article described one case of perineal hernia in a cat treated by method of application of a semitendinosus muscle flap.
Acta Veterinaria-beograd | 2014
Alan Genter; Hrvoje Capak; Marija Lipar; Marko Samardžija; Ivica Harapin; Ljiljana Bedrica; Darko Capak
Abstract The aim of this study was to evaluate three combinations of antibiotics applied perorally prior to laparotomy and gastrointestinal surgery and to select the most favorable combination. Research was performed on 24 female and male dogs divided into four groups. Following abdominal wall incision the caecum was compressed manually and 5 mL of saline solution was injected into it. Five mL of caecum contents was aspirated in a sterile syringe and only 0.1 mL was incubated into blood agar and homogenous agar. Bacterial colonies were counted and determined. Prior to surgery the control group (n=6) received no antibiotics. The group which received the combination of gentamicin and clindamycin (n=6) achieved the best reduction of E. coli whereas Enterococcus faecals was 100% destroyed. The group which received amoxicillin with clavulanic acid and metronidazole (n=6) acquired a reduction of bacteria Enterococcus faecalis, which could be sufficient for prophylaxis. The combination of gentamicin and erythromycin (n=6) failed to accomplish a reduction of the number of bacteria.
Acta Veterinaria Scandinavica | 2013
Hrvoje Valpotić; Gordan Mršić; Branka Gršković; Daniel Špoljarić; Dubravko Kezić; Siniša Srečec; Marijana Mataušić-Pišl; Gordana Lacković; Darko Capak; Damir Mihelić; Ksenija Vlahović; Ivica Valpotić; Ahmed Pirkić; Deny Andjelinović; Maja Popović
BackgroundBecause European-wide directives are restricting the non-clinical use of antibiotics as in-feed growth promotors in swine production, there is an intensive search for alternative strategies for control and prevention of losses among young pigs. With the growing knowledge of the porcine immune system and its endogenous modulation, it has been clearly established that exogenous immunomodulation using adjuvants and immune response modifiers (IRMs) represents an important prophylactic/therapeutic approach in the prevention/treatment of both stress- and microbial-induced disorders that accompaning weaning. However, it is essential to select a fully evaluated agent which may act either as a nonspecific IRM or synergistically as an adjuvant with vaccines. The synthetic macromolecules with a long history as adjuvant and IRM are nonionic block copolymers which consist of polyoxyethylene (POE) and polyoxypropylene (POP) molecules.MethodsThe aim of this work was to evaluate the effectiveness of POE-POP given as a single peroral dose on productivity parameters such as body weight gain, feed intake and feed conversion ratio, and systemic and intestinal immune parameters by assessing the proportions of CD45+ lymphoid cells, CD4+ and CD8+ T cells, and CD21+ B cells in the peripheral blood as well as the number of CD45RA+ naive lymphoid cells residing in the ileal mucosa in weaned pigs during a follow-up study 5 weeks after the treatment.ResultsPigs treated with POE-POP had better feed intake (+ 14.57%), higher average body mass at the end of the experiment (20.91 kg vs. 17.61 kg), and higher body weight gain in relation to Day 0 (191.63% vs. 144.58%) as well as in relation to nontreated pigs (+ 18.74%), with a lower feed conversion ratio (− 30.26%) in comparison to the control pigs. A much lower diarrhea severity score (5 vs. 54) was recorded in pigs treated with POE-POP (− 90.74%) than in the control pigs. A higher average diarrhea severity (ADS) was recorded in the control pigs (1.54 vs. 0.14), whereas the treatmant group had much a lower ADS ratio (− 90.91%) after 35 days of the experiment. The pigs that were treated with POE-POP had an increased proportion of CD45+, CD4+ and CD8+ cells at Day 21 (at p < 0.05, p < 0.05 or p < 0.01, respectively), Day 28 (at p < 0.01, respectively) and Day 35 (at p < 0.01, p < 0.05 or p < 0.01, respectively) as well as of CD21+ cells at Day 28 (p < 0.05) and Day 35 of the experiment (p < 0.01). Also, these pigs had more numerous CD45RA+ cells in interfollicular (p < 0.05) and follicular areas (p < 0.01) of the ileal Peyer’s patches than did control pigs.ConclusionThis property of POE-POP to induce recruitment of circulating and intestinal immune cell subsets in weaned pigs may allow the use of IRM-active block copolymers as adjuvants for vaccines, particularly those orally delivered and targeted to the gut-associated lymphoid tissues that are well known to promote rather tolerogenic than protective immune responses.
Veterinarski Arhiv | 2001
Darko Capak; Antun Brkić; Ivica Harapin; Dražen Matičić; Berislav Radišić
Veterinarski Arhiv | 2010
Berislav Radišić; Darko Capak; Dražen Matičić; Ivica Harapin; Josip Kos; Tomislav Babić; Gordana Nedeljković
Collegium Antropologicum | 2008
Marijo Bekić; Slavko Davila; Mato Hrskanović; Marijana Bekić; Sven Seiwerth; Viktorija Erdeljić; Darko Capak; Vladimir Butković
Veterinarski Arhiv | 2007
Mario Kreszinger; Domagoj Delimar; Josip Kos; Nataša Jovanov; Dražen Vnuk; Dražen Matičić; Boris Pirkić; Marko Stejskal; Darko Capak
Veterinarska stanica | 2014
Boris Pirkić; Darko Capak; Dubravko Kezić; Mirna Tominac Trcin; Njetočka Gredelj Šimec; Hrvoje Borošak; Mirna Abaffy; Lea Slunjski; Gordan Mršić; Daniel Špoljarić; Damir Mihelić; Maja Popović
Veterinarski Arhiv | 2008
Ivica Harapin; Ljiljana Bedrica; Damjan Gračner; Darko Capak; Marijan Benić; Borivoj Petrešević
Proceedings from the 5th Middle-European Buiatrics congress, Hajduszoboszlo, Hungary | 2004
Ivica Harapin; Ljiljana Bedrica; Vladimir Hahn; Damjan Gračner; Darko Capak; Labura, Čedomir, Levar Berislav