Darrell E. Fox

β-Selective nucleoside analog synthesis from chlorofuranoses

Abstract A method to form glycosyl linkages between nitrogen-containing heterocycles and appropriately protected furanoses is described. The method is highly beta-selective, operationally simple, and utilizes readily available reagents making the process amenable to scaleup. Representative examples of coupling between chlorofuranoses and purines or pyrrolopyrimidines are described.

Synthesis of 2-Bromo-4, 5-Difluorobenzolc Acid

Abstract The synthesis of 2-bromo-4, 5-difluorobenzoic acid was achieved from difluorophthalic anhydride by either using a Losen rearrangement or the Barton bromodecarboxylation reaction.