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Darren R. March

University of Queensland

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Publication

Featured researches published by Darren R. March.

Bioorganic & Medicinal Chemistry Letters | 1996

Structure-activity relationships for macrocyclic peptidomimetic inhibitors of HIV-1 protease

Giovanni Abbenante; Douglas A. Bergman; Ross I. Brinkworth; Darren R. March; Robert C. Reid; P.A. Hunt; I.W. James; R.J. Dancer; B. Garnham; M.L. Stoermer; David P. Fairlie

Abstract A series of appended macrocycles were synthesized and tested as inhibitors of HIV-1 protease (HIV PR). The macrocycle structurally mimics an N-terminal tripeptide component of peptide substrates. Structure-activity relationships explore steric limitations to the size and shape of the substituents and provide evidence for functional mimicry of substrate components.

Current Medicinal Chemistry | 1995

Macrocyclic peptidomimetics - Forcing peptides into bioactive conformations

David P. Fairlie; G Abenante; Darren R. March

Journal of Medicinal Chemistry | 2000

Conformational selection of inhibitors and substrates by proteolytic enzymes: Implications for drug design and polypeptide processing

David P. Fairlie; Joel D. A. Tyndall; Robert C. Reid; A. K. Wong; Giovanni Abbenante; Martin J. Scanlon; Darren R. March; Douglas A. Bergman; Christina L. L. Chai; Brendan A. Burkett

Molecular Pharmacology | 2004

Potent Cyclic Antagonists of the Complement C5a Receptor on Human Polymorphonuclear Leukocytes. Relationships between Structures and Activity

Darren R. March; Lavinia M. Proctor; Martin J. Stoermer; Robert Sbaglia; Giovanni Abbenante; Robert C. Reid; Trent M. Woodruff; Khemar Wadi; Natalii J Paczkowski; Joel D. A. Tyndall; Stephen M. Taylor; David P. Fairlie

Journal of Medicinal Chemistry | 2000

Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease.

Joel D. A. Tyndall; Robert C. Reid; David Tyssen; Darren Jardine; Belinda Todd; Margaret Passmore; Darren R. March; Leonard K. Pattenden; Douglas A. Bergman; Dianne Alewood; Shu-Hong Hu; Paul F. Alewood; Christopher J. Birch; Jennifer L. Martin; David P. Fairlie

Journal of the American Chemical Society | 1996

Substrate-based cyclic peptidomimetics of Phe-Ile-Val that inhibit HIV-1 protease using a novel enzyme-binding mode.

Darren R. March; Giovanni Abbenante; Douglas A. Bergman; Ross I. Brinkworth; W. A. Wickramasinghe; Jake Begun; Jennifer L. Martin; David P. Fairlie

Biochemistry | 1999

Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.

Jennifer L. Martin; Jake Begun; Aaron Schindeler; Wasa A. Wickramasinghe; Dianne Alewood; Paul F. Alewood; Douglas A. Bergman; Ross I. Brinkworth; Giovanni Abbenante; Darren R. March; Robert C. Reid; David P. Fairlie

Angewandte Chemie | 2003

A Cyclic Metallopeptide Induces α Helicity in Short Peptide Fragments of Thermolysin

Michael J. Kelso; Huy N. Hoang; Warren V. Oliver; Nikolai Sokolenko; Darren R. March; Trevor G. Appleton; David P. Fairlie

Journal of the American Chemical Society | 1995

Regioselective Structural and Functional Mimicry of Peptides - Design of Hydrolytically-Stable Cyclic Peptidomimetic Inhibitors of Hiv-1 Protease

Giovanni Abbenante; Darren R. March; Douglas A. Bergman; P.A. Hunt; B. Garnham; R.J. Dancer; Jennifer L. Martin; David P. Fairlie

Journal of the American Chemical Society | 1996

A Novel Bicyclic Enzyme Inhibitor as a Consensus Peptidomimetic for the Receptor-Bound Conformations of 12 Peptidic Inhibitors of HIV-1 Protease

Robert C. Reid; Darren R. March; Michael J. Dooley; Doug A. Bergman; Giovanni Abbenante; David P. Fairlie

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David P. Fairlie

University of Queensland

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Giovanni Abbenante

University of Queensland

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Robert C. Reid

University of Queensland

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Douglas A. Bergman

University of Queensland

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Jennifer L. Martin

University of Queensland

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Ross I. Brinkworth

University of Queensland

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Joel D. A. Tyndall

University of Otago

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B. Garnham

University of Queensland

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Dianne Alewood

University of Queensland

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Huy N. Hoang

University of Queensland

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