Dattatray Chandam

Novel Brønsted Acidic Ionic Liquid ([CMIM][CF3COO]) Prompted Multicomponent Hantzsch Reaction for the Eco-Friendly Synthesis of Acridinediones: An Efficient and Recyclable Catalyst

AbstractsA novel, highly efficient and recyclable Brønsted acidic ionic liquid ([CMIM][CF3COO]) has been successfully implemented for the synthesis of acridinediones in aqueous media. Recyclability of novel catalyst, high yields, use of environmentally benign aqueous media as solvent, simple product isolation, high atom economy and sidestep to column chromatography are the noteworthy features of this protocol. This protocol is competent for producing wide library of acridinediones in good to excellent yields. Furthermore, molecular structure and relative stereochemistry of 4c and 4s derivatives were confirmed by single-crystal X-ray diffraction.Graphical Abstract

(±)-Camphor-10-sulfonic acid catalyzed atom efficient and green synthesis of triazolo[1,2-a]indazole-triones and spiro triazolo[1,2-a]indazole-tetraones

Abstract(±)-Camphor-10-sulfonic acid is used for the synthesis of triazolo[1,2-a]indazole-triones and spiro triazolo[1,2-a]indazole-tetraones by condensation reaction of dimedone, urazole and aromatic aldehydes or isatin. The noteworthy aspects of this new method are high yields, high atom efficiency, use of non-toxic solvent, mild conditions, simple workup and synthesis of complex molecules using an eco-friendly, inexpensive catalyst.Graphical Abstract

Oxalic acid dihydrate: proline as a new recyclable designer solvent: a sustainable, green avenue for the synthesis of spirooxindole

The quest to develop an environmentally friendly, sustainable protocol for immensely bioactive spirooxindole derivatives has encouraged to explore oxalic acid dihydrate: proline low transition temperature mixture as a new designer solvent for the said synthesis at room temperature. It has been successfully applied for the three component reaction of isatin, malononitrile or ethyl cyanoacetate and 1,3–dicarbonyl compounds for the first time. Moderate to good yield of the products, shorter reaction time, energy efficiency, chromatography-free purification process, recyclability and high atom economy are the captivating feature of this protocol which will find applications in multi-component, diversity-oriented synthesis.Graphical Abstract

(±)-Camphor-10-sulfonic acid as recyclable and efficient catalyst for the synthesis of some novel coumarin derivatives

ABSTRACT A highly competent-diversity oriented synthesis of coumarin core derivatives using a Knoevenagel condensation followed by Michael addition and subsequent cyclization in the presence of (±)-camphor-10-sulfonic acid in a water/ethanol (1:1) solvent system is depicted. Furthermore, easy workup procedures with good yield, rapid reactions with high atom economy, and catalyst recyclability are the fascinating features of the procedure. GRAPHICAL ABSTRACT

Novel dibenzo-18-crown-6 ether functionalized bis-benzimidazole derivatives: synthesis and antifungal evaluation

A series of novel 18-crown-6 ether functionalized bis-benzimidazole derivatives (3a–g) have been synthesized by reacting various substituted ortho-phenylene diamines and pyridine diamines with 4,4′-diformyl dibenzo-18-crown-6 ether (1). The required starting material 4,4′-diformyl dibenzo-18-crown-6 ether (1) was prepared by Duff formylation method. All synthesized novel molecules have been identified on the basis of infrared (IR), 1H nuclear magnetic resonance (NMR), 13C NMR, mass spectroscopy (MS), and elemental analyses. The title compounds (3a–g) were tested for antifungal activity against Aspergillus niger, Trichothecium sp., Rhizopus sp., and Sclerotium rolfsii fungi species using agar well diffusion method, showing mild to good results.Graphical abstract

Target Oriented Selective Synthesis of Antibacterial Active Tyrosinase Enzyme Inhibitor Coumarin Core Derivatives

Target oriented designs and selective synthesis of bioactive molecules with broad spectrum activity is a challenging job in the field of modern organic chemistry. Considering this opportunity herein, we report a highly competent selective synthesis of bioactive coumarin core derivative. Using computational drug design software only four selective antibacterial active derivatives was discovered and then synthesized. The efficiency of the synthesized compounds was scrutinized against bacterial pathogens such as P. vulgaris and B. megaterium. All the synthesized compounds showed better theoretical as well as practical results against selected pathogenic species. The minimum inhibitory concentration (MIC) values of the most active heterocycles were compared with that of ciprofloxacin. Results obtained in tyrocinase inhibition assay exactly correlate with MIC results and docking outcomes. The bioactivity of these type moieties provided a novel approach to develop new types of antibacterial drugs like entities effective against pathogens.