David A. Campbell

Trimethylorthoformate: A mild and effective dehydrating reagent for solution and solid phase imine formation

Abstract Trimethylorthoformate has been found to be an effective dehydrating solvent for the formation of imines, both in the solid phase as well as solution phase.

A SIMPLE PROCEDURE FOR THE SOLID PHASE SYNTHESIS OF DIKETOPIPERAZINE AND DIKETOMORPHOLINE DERIVATIVES

Abstract A novel route for the synthesis of diketopiperazines and diketomorpholines on a solid support is described. Two different approaches are reported for diketopiperazines. The cyclization step involves cyclization with simultaneous cleavage from the resin.

The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases

A series of succinyl based mercaptoketones and diastereomeric mercaptoalcohols were prepared and evaluated in vitro as inhibitors of the matrix metalloproteinases collagenase-1 (MMP-1), stromelysin (MMP-3), and gelatinase-B (MMP-9).