David A. McGuire

Preliminary results of an absorbable interference screw

A randomized, prospective multicenter comparison was done of a bioabsorbable interference screw (Bioscrew; Linvatec Corp, Largo, FL) made from poly L-lactic acid and a metal interference screw produced by the same company. Assignment was randomized by sealed envelopes. A total of 110 patients underwent arthroscopic patellar tendon autografts. A minimum 12 months follow-up is available on 85 patients (mean 19 months, range 12 to 33) including 42 with Bioscrews and 43 with metal screws. There were 56 male and 29 female patients. The average age was 29 years (16 to 50 years). Tourniquet times and associated surgical findings were similar for the two groups. Postoperative Tegner and Lysholm scores were not statistically different between the two groups. KT tests at 1 year showed an average 20-lb laxity of 1.8 mm for the Bioscrew and 1.2 mm for the metal screw groups. The average 1-year KT maximum manual side-to-side difference was 1.6 mm for Bioscrews and 1.6 mm for metal screws. A pivot shift was absent in 83% of Bioscrews and 90% of metal screws at follow-up. Six of 85 Bioscrews inserted (7%) broke on insertion (all were 7-mm diameter screws at the femoral site). No additional fixation was required in four cases. In two, the broken screw was replaced. No lytic bone changes or tunnel widening were found with any Bioscrew. One metal screw had tibial tunnel widening. No statistical difference was found between the Bioscrew and the metal screw groups. Short-term data support the conclusion that the Bioscrew is a reasonable alternative to metal interference screws.

Articular Cartilage Regeneration With Autologous Peripheral Blood Progenitor Cells and Hyaluronic Acid After Arthroscopic Subchondral Drilling: A Report of 5 Cases With Histology

PURPOSE The purpose of this study was to evaluate the quality of articular cartilage regeneration after arthroscopic subchondral drilling followed by postoperative intraarticular injections of autologous peripheral blood progenitor cells (PBPCs) in combination with hyaluronic acid (HA). METHODS Five patients underwent second-look arthroscopy with chondral core biopsy. These 5 patients are part of a larger pilot study in which 180 patients with International Cartilage Repair Society grade III and IV lesions of the knee joint underwent arthroscopic subchondral drilling followed by postoperative intra-articular injections. Continuous passive motion was used on the operated knee 2 hours per day for 4 weeks. Partial weight bearing was observed for the first 6 to 8 weeks. Autologous PBPCs were harvested 1 week after surgery. One week after surgery, 8 mL of the harvested PBPCs in combination with 2 mL of HA was injected intra-articularly into the operated knee. The remaining PBPCs were divided into vials and cryopreserved. A total of 5 weekly intra-articular injections were given. RESULTS Second-look arthroscopy confirmed articular cartilage regeneration, and histologic sections showed features of hyaline cartilage. Apart from the minimal discomfort of PBPC harvesting and localized pain associated with the intra-articular injections, there were no other notable adverse reactions. CONCLUSIONS Articular hyaline cartilage regeneration is possible with arthroscopic subchondral drilling followed by postoperative intraarticular injections of autologous PBPCs in combination with HA. LEVEL OF EVIDENCE Level IV, therapeutic case series.

Is an anterior cruciate ligament reconstruction outcome age dependent

Treatment of a torn anterior cruciate ligament (ACL) in older patients must be considered in relation to healing delays, rehabilitation difficulties, stiffness, arthritis, and actual athletic demands. This study compares ACL reconstructions in patients 40-years old and older with those under 40-years old and contrasts these to published nonoperative data in the 40 and older patient. Patients undergoing ACL reconstruction between 1992 and 1994 were preoperatively and postoperatively assessed with Lysholm, Tegner, KT, radiographic, and clinical examinations. They were divided into two groups: those 40 years and older (group 1) and those 39 years and younger (group 2). Group 1 had 33 patients with an average age of 44 years (range, 40 to 52 years). Radiographic Fairbank changes were absent. Group 2 had 170 patients with an average age of 27 years (range, 16 to 39 years). Group 1 preoperative instability and intake data were not statistically different from those of group 2. Average follow-up was 21 months for both groups. Both groups showed significant improvement in all parameters at 12- and 24-month follow-up examinations. Lysholm scores, Tegner scores, average KT manual maximum side-to-side differences, Lachman tests, and pivot shift testing were not statistically different in either group. Using Lysholm criteria, in group 1, 89% had excellent/good results, and 11% fair/poor results. This was not statistically different from group 2, which showed 91% excellent/good results and 9% fair/poor results at 24-month follow-up examination. For this age group, nonoperative treatment reports indicate 57% excellent/good results and 43% fair/poor results. The outcomes between these groups are the same and fail to establish the age of 40 years as a barrier to successful ACL reconstruction.

Articular cartilage lesions of the knee

The pathogenesis and clinical significance of articular cartilage lesions of the knee persist as topics of considerable interest among orthopedic surgeons. This study was designed to assess the association of articular cartilage degeneration with concomitant intraarticular abnormalities and to correlate the prevalence and severity of articular cartilage damage with preoperative historical and physical exam findings in patients presenting with knee pain. Twenty-six history and physical exam data points were prospectively collected from 192 patients (200 knees), consecutively undergoing arthroscopic knee surgery. During surgery, all articular cartilage lesions were recorded with respect to size, location, and character and were graded according to Oglivie-Harris et al. All concomitant knee joint abnormalities were simultaneously recorded. Of 200 knees examined arthroscopically, 12 knees revealed no demonstrable etiology for the presenting symptoms, 65 knees revealed assorted intraarticular pathology but no articular cartilage degeneration, and the remaining 123 knees revealed a total of 211 articular cartilage lesions (103 femoral, 72 patellar, 36 tibial); 7 femoral, 6 patellar and 0 tibial lesions were completely isolated (no concomitant knee joint pathology). The concomitance of femoral defects with tibial lesions was highly significant (p = 0.01). Femoral and tibial articular cartilage lesions were strikingly correlated with the presence of an unstable torn meniscus (p less than 0.001). Medial compartment articular cartilage lesions were significantly more common (p = 0.001), more closely associated with meniscal derangement, and appreciably more severe than lateral compartment lesions. In 75% of anterior cruciate ligament-deficient knees with concomitant articular cartilage degeneration, the duration from injury to surgery was greater than 9 months, and in each of these cases, a history of reinjury to the knee was elicited. From these data one can conclude that: (a) in some patients with painful knees, isolated articular cartilage lesions may be the only abnormality noted at arthroscopy; (b) unstable meniscal tears are significantly associated with destruction of articular cartilage; (c) the medial compartment is particularly susceptible to articular cartilage degeneration; and (d) in our series, anterior cruciate ligament tears were increasingly associated with articular cartilage destruction as the elapsed time from injury to arthroscopy increased.

Bioscrew fixation of patellar tendon autografts.

Biodegradable interference screw fixation was studied using patellar tendon autografts in a randomized, prospective multicenter comparison of the PLLA Bioscrew and a metal interference screw. sixty-eight of 114 (60%) patients (34 Bioscrew and 34 metal screw) enrolled were available for follow up an average of 35 months after surgery (range 24-65). There were 42 males and 26 females with an average age of 29 years (16-50). Tourniquet times and associated surgical findings were similar for the two groups. Postoperative KT, Tegner, and Lysholm scores were not statistically different between the two groups. Average follow up KT maximum manual side-to-side difference was 0.9 mm for Bioscrews and 1.4 mm for metal screws. Postoperative Lachman and pivot shift testing were equivalent for the two groups. Other than six of the 7 mm Bioscrews breaking during insertion in the femoral tunnel, there were no problems related to the PLLA implants. No statistical difference was found between the Bioscrew and the metal screw groups, and there were no osteolytic or other reactive bone changes observed associated with the PLLA Bioscrew. These data indicate that the PLLA Bioscrew functions reliably as an interference fixation screw for patellar tendon autografts.

Comparison of ketorolac and opioid analgesics in postoperative ACL reconstruction outpatient pain control

Pain control is an important postoperative consideration with any surgical procedure. Technological and procedural improvements have contributed to the reduction in both the degree of surgical difficulty and the postsurgical complications associated with intricate surgeries. As a result, certain surgeries have potential for being performed on an outpatient basis, dependent upon appropriate pain-management regimens and the degree of potential for postoperative complications. Arthroscopic anterior cruciate ligament (ACL) reconstruction is a common procedure. Because of the reduction in invasiveness that arthroscopy provides, outpatient surgery is now routinely employed for ACL patients. The arguments against ACL outpatient surgery have included the reluctance to use ambulatory, indwelling, intravenous pain-pump delivery systems for opioid pain medication. The purpose of this study was to determine the efficacy of a ketorolac tromethamine used for the management of the postoperative pain produced as a result of outpatient ACL reconstruction. When the ketorolac pain management regimen is compared in this setting with meperidine or morphine, pain control is as good as, or in some cases better than, either of the opioid drugs. Additionally, the adverse side effects associated with opioid drugs are significantly reduced at a substantially lower direct cost to the patient.

Allograft tissue in ACL reconstruction.

Musculoskeletal allografts are an essential component for the surgical management of orthopedic injuries. Allografts are most frequently used in the knee for anterior cruciate ligament (ACL) deficiency and less frequently for other ligament lesions, meniscal transplant, and osteochondral repair. Clinical ACL outcomes have continued to improve as techniques and instrumentation have developed. Allografts are routinely used for ACL reconstructions and although some may argue against them, others feel that not using allografts is a disservice to their patients. The increase in demand for a larger and safer supply of allografts is directly related to the growth in the number of allografts being used. Allografts are safe, reliable, and when all factors are considered, is an excellent ligament replacement solution surgeons should consider for their ACL patients.

Comparison of anatomic versus nonanatomic placement of femoral tunnels in Achilles double-bundle posterior cruciate ligament reconstruction.

PURPOSE In this study, we compared femoral tunnel pairs that differ by group in a double-bundle Achilles tendon allograft posterior cruciate ligament (PCL) reconstruction. METHODS Group 1 patients had femoral tunnels drilled nearly within the footprint area most proximal and most distal to the axis of the femur. Group 2 patients had femoral tunnels drilled eccentrically within the footprint along an axis nearly perpendicular to the axis of the femur. Patient assessments were made subjectively with preoperative and postoperative assessments of Lysholm rating scale, posterior drawer test, and dial test. Objective assessments used range of motion and quadriceps circumference. Group 1 contained 7 patients with a mean age of 32 years (range, 20 to 46 years). Group 2 contained 10 patients with a mean age of 32 years (range, 20 to 46 years). RESULTS Group 2 patients had significantly less posterior laxity than group 1 patients. Postoperatively, 6 patients in group 1 (86%) had a positive posterior drawer test compared with 3 in group 2 (30%). Rotational laxity was identified by dial test results postoperatively in 3 patients in group 1 (43%) compared with 0% in group 2. Extension deficit occurred in 2 patients in group 1 (29%) and 1 patient in group 2 (10%). Flexion deficit occurred more than twice as frequently in group 1 (71% [5 patients]) than in group 2 (30% [3 patients]). There were no statistically significant differences for other comparisons. CONCLUSIONS The clinical outcomes support the group 2 method with femoral tunnel placement at the anterior-most and posterior-most portions of the femoral PCL insertion. The group 2 procedure described in this study incorporates advanced principles for successful outcomes with Achilles double-bundle PCL reconstruction. LEVEL OF EVIDENCE Level III, case-control study.

The Relationship Between Anterior Cruciate Ligament Reconstruction Tibial Tunnel Location and the Anterior Aspect of the Posterior Cruciate Ligament Insertion

A retrospective study of arthroscopic anterior cruciate ligament reconstruction in 20 patients was conducted. These patients underwent computed tomography (CT) scans on the involved knee postoperatively to determine sagittal placement of the proximal end of the tibial tunnel (TTp) based on a distance from a specific anatomic reference known as the over-the-back (OTB) ridge. The distance from the posterior aspect of the TTp to the OTB ridge, defined as the backset, was measured from the CT scans. The mean backset was 6.2 mm. The anterior to posterior (AP) tibial plateau diameter was measured from the CT and by plain view radiograph. The mean AP diameter by CT scan was 55.1 mm and the mean AP diameter by radiograph was 55.4 mm. A Pearson correlation coefficient of r = .633 comparing backset versus AP diameter suggests a moderately significant positive relationship. For the AP diameter comparing measurement method, CT versus radiograph, r = .985, representing a highly significant positive relationship, confirming AP diameter sizing accuracy by inexpensive radiography versus CT scan. A proposed backset model based on these data uses three fixed distances, derived by ratio, within a 2-mm range. This model is defined by 5-, 6-, and 7-mm backset intervals for < 50 mm, 50 to 60 mm, and > 60 mm AP diameters respectively, and is currently under prospective clinical investigation.

Meniscal Impingement Syndrome

The meniscal impingement syndrome consists of three elements: impaction on the anterior medial femoral condyle by the leading edge of the medial meniscus, articular cartilage damage of at least Outerbridge grade 3, and knee hyperextension of at least 5 degrees. This report reviews this condition in a series of seven knees with an average follow-up of 39 months. The time from the onset of symptoms until surgery averaged 45 months. Treatment consisted of a thorough arthroscopic knee evaluation and debridement of the articular cartilage fragmentation and any impinging synovitis. Postoperative rehabilitation includes extension block bracing, hamstring strengthening, and closed-chain exercise. With this regimen, there was improvement in the Tegner scores and a reduction in postoperative knee hyperextension. Identification of this uncommon condition requires a complete evaluation of the medial femoral condyle in patients with knee hyperextension.