David A. Melanson

Characterization of the formation of interfacially photopolymerized thin hydrogels in contact with arterial tissue

The aim of this study was to examine the conditions under which an interfacial photopolymerization process results in hydrogel barriers. Visible light initiated interfacial photopolymerization of a polyoxyethylene glycol (PEG)-co-poly(alpha-hydroxy acid) copolymer based on PEG 8000 macromonomer was performed on porcine aortic tissue, resulting in conformal hydrogel barriers. The process conditions were optimized in vitro for the formation of a 5-100 microns thick barrier.