David A. Ofusori

Dextrocardia and Situs Inversus Totalis in a Nigerian Cadaver: A Case Report of Rare Anomaly

Este reporte describe a un cadaver adulto nigeriano de sexo masculino con dextrocardia y situs inversus totalis. Las ilustraciones fotograficas revelaron transposicion de algunas de las visceras, como el estomago y el bazo que se encuentra en el derecho y el higado y la vesicula biliar a la izquierda. Ademas, el pulmon izquierdo era tri-lobulado, mientras que el derecho uni-lobulado. El corazon fue aplanado y situado a la derecha, por consiguiente, transposicionando los grandes vasos. El reporte demostro que la dextrocardia y el situs inversus existen entre los nigerianos y, posiblemente, los africanos, por tanto, se recomienda un temprano examen medico, ya que pacientes con esta condicion no son conscientes de su inusual anatomia hasta que acuden al medico por atencion por una condicion no relacionada. La deteccion temprana puede conducir a un exito quirurgico y, en consecuencia, ofrecer una segura oportunidad de sobrevivir.

Supracondylar and infratubercular processes observed in the humeri of Nigerians

We present the first recorded supracondylar and infratubercular processes of humerus among Nigerians of the West African nation. Morphometrical analyses of 40 humeri (20 left and 20 rights) were conducted. One of the humeri possesses the supracondylar spine which measures 1.6 cm and stands at 100o on the anteromedial surface 5.5 cm above the medial epicondyle and exactly midway between the medial epicondyle and nutrient foramen. We also report the first infratubercular process ever.

Effect of zinc sulphate and Essentiale® Forte in managing carbon tetrachloride-induced hepatotoxicity in adult Wistar rats

Objectives: The aim of this study was to assess and compare the ameliorative effect of zinc sulphate and Essentiale® Forte on the histomorphology and lipid histochemistry of carbon tetrachloride (CCl4)-induced hepatic injury in adult Wistar rats. Methods: Twenty-five adult Wistar rats, weighing between 150 g and 170 g, were used for the study. The animals were divided into five groups A, B, C, D and E (n=5). Group A received 0.7 ml/kg of olive oil orally. Groups B, C, D and E were administered CCl4 (0.7 ml/kg, orally) for 1 week in 1:1 dilution with olive oil. After CCl4 administration, Group C was treated with Essentiale® Forte (4.5 mg/kg/bw, orally) for four weeks. Group D was treated with zinc sulphate (7 mg/kg/bw, orally) daily for four weeks. Group E received zinc sulphate (7 mg/kg/bw, orally) and Essentiale® Forte (4.5 mg/kg/bw, orally) for a period of 4 weeks, while Group B was left untreated. Animals were left for another one week and subsequently sacrificed under ether anaesthesia. The liver was harvested, weighed and divided into two parts for histological and histochemical studies. Results: Histological analysis showed that treatment of liver with CCl4 caused hepatotoxicity as marked by presence of inflammatory cells and distortion in the connective tissue fibers, as compared to the ones treated with zinc sulphate and or Essentiale® Forte which restored the hepatic histoarchitecture and protected the liver tissue from fatty and degenerative changes. Conclusion: This study showed that combination of Essentiale® Forte and zinc supplement offered better ameliorative effects on the liver of Wistar rats following CCl4-induced hepatotoxicity compared with separate administration of either Essentiale® Forte or zinc sulphate.