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Dive into the research topics where David A. Stein is active.

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Featured researches published by David A. Stein.


Virology | 2008

Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers

Slobodan Paessler; Rene Rijnbrand; David A. Stein; Haolin Ni; Nadezhda E. Yun; Natallia Dziuba; Viktoriya Borisevich; Alexey Seregin; Yinghong Ma; Robert Blouch; Patrick L. Iversen; Michele A. Zacks

n Abstractn n The genus Alphavirus contains members that threaten human health, both as natural pathogens and as potential biological weapons. Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMO) enter cells readily and can inhibit viral replication through sequence-specific steric blockade of viral RNA. Sindbis virus (SINV) has low pathogenicity in humans and is regularly utilized as a model alphavirus. PPMO targeting the 5′-terminal and AUG translation start site regions of the SINV genome blocked the production of infectious SINV in tissue culture. PPMO designed against corresponding regions in Venezuelan equine encephalitis virus (VEEV) were likewise found to be effective in vitro against several strains of VEEV. Mice treated with PPMO before and after VEEV infection were completely protected from lethal outcome while mice receiving only post-infection PPMO treatment were partially protected. Levels of virus in tissue samples correlated with animal survival. Uninfected mice suffered no apparent ill-effects from PPMO treatment. Thus, PPMO appear promising as candidates for therapeutic development against alphaviruses.n n


Archive | 2002

Antisense antiviral agent and method for treating ssRNA viral infection

David A. Stein; Douglas E. Skilling; Patrick L. Iversen; Alvin W. Smith; Dwight D. Weller


Archive | 2004

Oligonucleotide analog and method for treating flavivirus infections

Patrick L. Iversen; David A. Stein


Archive | 2004

Compositions for enhancing transport and antisense efficacy of nucleic acid analog into cells

Patrick L. Iversen; Hong M. Moulton; Michelle H. Nelson; Andrew D. Kroeker; David A. Stein


Archive | 2006

Method for treating enterovirus or rhinovirus infection using antisense antiviral compounds

David A. Stein; Richard K. Bestwick; Patrick L. Iversen; Dwight D. Weller


Archive | 2006

Antisense antiviral compounds and methods for treating foot and mouth disease

Aida E. Rieder; David A. Stein; A. Vagnozzi; Dwight D. Weller; Patrick L. Iversen


Archive | 2007

Antivirale antisense-verbindung und verfahren zur behandlung von arenavirus-infektion

Benjamin W. Neuman; David A. Stein; Michael J. Buchmeier; Patrick L. Iversen


Archive | 2007

Antivirale antisense-verbindung und verfahren zur behandlung von arenavirus-infektion Antiviral antisense compound and methods for treatment of arena virus-infection

Benjamin W. Neuman; David A. Stein; Michael J. Buchmeier; Patrick L. Iversen


Archive | 2005

Antivirale antisense-verbindungen und verfahren zur behandlung von filovirus-infektionen

David A. Stein; Patrick L. Iversen; Sina Bavari


Archive | 2005

Antivirale antisense-verbindung und verfahren zur behandlung einer ssrna-virusinfektion

Patrick L. Iversen; David A. Stein

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Alvin W. Smith

University of California

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