David Brandon Whitt

Accelerated spectroscopic imaging of hyperpolarized C-13 pyruvate using SENSE parallel imaging.

The ability to accelerate the spatial encoding process during a chemical shift imaging (CSI) scan of hyperpolarized compounds is demonstrated through parallel imaging. A hardware setup designed to simultaneously acquire 13C data from multiple receivers is presented here. A system consisting of four preamplifiers, four gain stages, a transmit coil, and a four receive channel rat coil was built for single channel excitation and simultaneous multi‐channel detection of 13C signals. The hardware setup was integrated with commercial scanner electronics, allowing the system to function similar to a conventional proton multi‐channel setup, except at a different frequency. The ability to perform parallel imaging is demonstrated in vivo. CSI data from the accelerated scans are reconstructed using a self‐calibrated multi‐spectral parallel imaging algorithm, by using lower resolution coil sensitivity maps obtained from the central region of k‐space. The advantages and disadvantages of parallel imaging in the context of imaging hyperpolarized compounds are discussed. Copyright

Three-frequency RF coil designed for optimized imaging of hyperpolarized, 13C-labeled compounds

Imaging exams involving hyperpolarized, 13C‐labeled compounds require novel RF coils for efficient signal utilization. While 13C coils are required for mapping the spatial distribution of the hyperpolarized compounds, imaging/pulsing at different frequencies is also needed for scan setup steps prior to the image acquisition. Imaging/pulsing at the 1H frequency is typically used for anatomical localization and shimming. Flip angle (FA) calibration, which is difficult or impossible to achieve at the 13C frequency, can be accurately performed at the 23Na frequency using the natural abundance signal that exists in any living tissue. We demonstrate here a single RF resonant structure that is capable of operating linearly at the 1H and 23Na frequencies for scan setup steps, and in quadrature at the 13C frequency for imaging. Images at the three resonant frequencies of this coil are presented from an exam involving hyperpolarized 13C compounds in vivo. Magn Reson Med 60:928–933, 2008.