David C. Whitcomb

Clinical Profile, Etiology, and Treatment of Chronic Pancreatitis in North American Women: Analysis of a Large Multicenter Cohort.

Objective Historically, chronic pancreatitis (CP) was considered a disease of alcoholic males, but recent data suggest its etiology to be complex. To better understand CP in women, we compared data on women and men with CP in a large, prospectively ascertained multicenter US cohort. Methods Patients with CP enrolled in the NAPS2 Continuation and Validation study were studied. Information on demographics, etiology, risk factors, phenotype, and treatment(s) used was obtained from detailed questionnaires completed by the patients and physicians. Results Of 521 cases, 45% were women. Women were significantly (P < 0.05) less likely to have alcohol etiology (30% vs 58.5%) and more likely to have nonalcoholic etiologies (idiopathic, 32% vs 18%; obstructive, 12% vs 2.4%; genetic, 12.8% vs 7.3%). Demographics, pain experience, morphologic findings, exocrine and endocrine insufficiency, CP-related disability, and use of medical therapies were mostly similar in both sexes. Sphincterotomy (biliary, 33% vs 24%; pancreatic, 38% vs 28%; P < 0.05) was performed more frequently in women, whereas cyst/pseudocyst operations were more common in men (6.6 vs 2.6%, P = 0.02). Conclusions Most CP cases in women are from nonalcoholic etiologies. In contrast to many other chronic diseases, clinical phenotype of CP is determined by the disease and is independent of sex.

Conference report for APA postgraduate course: clinical controversies in pancreatobiliary diseases.

The Annual Meeting of the American Pancreatic Association (APA) draws basic scientists and clinical experts in pancreatic diseases from multiple disciplines and multiple countries to Chicago on a yearly basis. This event provides a unique opportunity for the presentation of a continuing medical education (CME) course from a multidisciplinary approach with an outstanding international faculty. With this in mind a postgraduate CME course, jointly sponsored by the University of Pittsburgh School of Medicine and the Northwestern University Feinberg School of Medicine in collaboration with the APA and the National Pancreas Foundation, was presented. These organizations conducted a 1-day course entitled ‘‘Clinical Controversies in Pancreatobiliary Diseases,’’ which occurred immediately after the annual APA meeting. The course was designed to address some of the new and controversial areas of research and clinical practice, especially related to cystic lesions of the pancreas and pancreatic cancer.