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Dive into the research topics where David H. Eidelman is active.

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Featured researches published by David H. Eidelman.


Neurology | 1993

Coenzyme Q10 with multiple vitamins is generally ineffective in treatment of mitochondrial disease

Paul M. Matthews; B. Ford; Ronald J. Dandurand; David H. Eidelman; D. O'Connor; A. Sherwin; George Karpati; F. Andermann; D.L. Arnold

We followed 16 patients with a variety of mitochondrial diseases over one to four periods of treatment (2 months each) with coenzyme Q10 plus vitamins K3 and C, riboflavin, thiamine, and niacin, using independent measures of oxidative metabolism to assess efficacy. There were large (<threefold) increases in serum coenzyme Q10 concentrations with treatment, but no measure of oxidative metabolism showed significant improvement with treatment for the group, nor did any individual patient show significant, reproducible, objective clinical improvement. The results suggest that coenzyme Q10 plus vitamin therapy does not significantly improve mitochondrial oxidative metabolism in patients with mitochondrial disease in general. Any clinical benefit that may follow from short-term administration appears slight.


The Lancet | 2004

Role of toll-like receptor 4 in protection by bacterial lipopolysaccharide in the nasal mucosa of atopic children but not adults.

Meri K. Tulic; Pierre-Olivier Fiset; John J. Manoukian; Saul Frenkiel; François Lavigne; David H. Eidelman; Qutayba Hamid

BACKGROUNDnExposure to bacterial products in early life could protect against development of atopy. We examined the effect of bacterial lipopolysaccharide on allergic inflammation and expression of cytokines and lipopolysaccharide receptor (toll-like receptor 4 TLR4) in nasal mucosa of 15 atopic children and ten atopic adults.nnnMETHODSnExplanted mucosa was cultured with allergen with or without lipopolysaccharide (0.1 mg/L) for 24 h. Immunocytochemistry and in-situ hybridisation were used to phenotype the cells and cytokines.nnnFINDINGSnIn explants from atopic children, lipopolysaccharide prevented allergen-induced T-helper type 2 (Th2) inflammation and upregulated Th1 cytokine reactivity and expression. These effects were blocked by antibody to interleukin 10. In children but not in adults, lipopolysaccharide caused increases of three times in T-cell reactivity, five times in T-cell proliferation, and four times in expression of interleukin 10 compared with mucosa stimulated with allergen alone. This difference in response was mirrored by lipopolysaccharide-induced increases in TLR4 reactivity in children but not adults. TLR4 receptor was expressed by CD3-positive T cells, and TLR4-positive cells contained interleukin 10. Lipopolysaccharide increased expression of cells positive for both CD3 and TLR4; both TLR4 and interleukin 10; and both CD4 and CD25.nnnINTERPRETATIONnLipopolysaccharide inhibits allergic inflammation in nasal mucosa of atopic children by skewing local immune responses from Th2 to Th1 and upregulating production of interleukin 10. These effects are mediated by TLR4. Our results emphasise an important difference between adults and children in their ability to respond to bacterial products. These differences could have a role in normal maturation of the immune system.


American Journal of Respiratory and Critical Care Medicine | 2000

Bronchial responsiveness among inbred mouse strains. Role of airway smooth-muscle shortening velocity.

Alexandre Duguet; Keltoum Biyah; Eleanor M. Minshall; R. F. M. Gomes; Chong-Gang Wang; Majda Taoudi-Benchekroun; Jason H. T. Bates; David H. Eidelman


American Journal of Respiratory and Critical Care Medicine | 2001

Nitric Oxide and Protein Nitration are Eosinophil Dependent in Allergen-Challenged Mice

Hiroaki Iijima; Alexandre Duguet; Seok-Yong Eum; Qutayba Hamid; David H. Eidelman


American Journal of Physiology-lung Cellular and Molecular Physiology | 2005

IL-13 may mediate allergen-induced hyperresponsiveness independently of IL-5 or eotaxin by effects on airway smooth muscle

Seok-Yong Eum; Karim Maghni; Barbara Tolloczko; David H. Eidelman; James G. Martin


American Journal of Respiratory Cell and Molecular Biology | 2003

Involvement of the Cysteinyl-Leukotrienes in Allergen-Induced Airway Eosinophilia and Hyperresponsiveness in the Mouse

Seok-Yong Eum; Karim Maghni; Qutayba Hamid; Holly Campbell; David H. Eidelman; James G. Martin


American Journal of Respiratory and Critical Care Medicine | 2001

Eosinophil peroxidase mediates protein nitration in allergic airway inflammation in mice.

Alexandre Duguet; Hiroaki Iijima; Seok-Yong Eum; Qutayba Hamid; David H. Eidelman


The Journal of Allergy and Clinical Immunology | 2000

Upregulation of the transcription factor GATA-3 in upper airway mucosa after in vivo and in vitro allergen challenge☆☆☆

Yutaka Nakamura; Pota Christodoulopoulos; Lisa Cameron; Erin D. Wright; François Lavigne; Masao Toda; Shigeo Muro; Anuradha Ray; David H. Eidelman; Eleanor M. Minshall; Qutayba Hamid


Chest | 1995

Mitochondrial Disease: Pulmonary Function, Exercise Performance, and Blood Lactate Levels

Ronald J. Dandurand; Paul M. Matthews; Douglas L. Arnold; David H. Eidelman


Canadian Journal of Physiology and Pharmacology | 1997

Heterogeneity of responsiveness of individual airways in cultured lung explants.

Eleanor M. Minshall; Chong-Gang Wang; Ron J. Dandurand; David H. Eidelman

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Alexandre Duguet

McGill University Health Centre

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Ronald J. Dandurand

Montreal Neurological Institute and Hospital

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