David H. Eidelman
Montreal Neurological Institute and Hospital
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Featured researches published by David H. Eidelman.
Neurology | 1993
Paul M. Matthews; B. Ford; Ronald J. Dandurand; David H. Eidelman; D. O'Connor; A. Sherwin; George Karpati; F. Andermann; D.L. Arnold
We followed 16 patients with a variety of mitochondrial diseases over one to four periods of treatment (2 months each) with coenzyme Q10 plus vitamins K3 and C, riboflavin, thiamine, and niacin, using independent measures of oxidative metabolism to assess efficacy. There were large (<threefold) increases in serum coenzyme Q10 concentrations with treatment, but no measure of oxidative metabolism showed significant improvement with treatment for the group, nor did any individual patient show significant, reproducible, objective clinical improvement. The results suggest that coenzyme Q10 plus vitamin therapy does not significantly improve mitochondrial oxidative metabolism in patients with mitochondrial disease in general. Any clinical benefit that may follow from short-term administration appears slight.
The Lancet | 2004
Meri K. Tulic; Pierre-Olivier Fiset; John J. Manoukian; Saul Frenkiel; François Lavigne; David H. Eidelman; Qutayba Hamid
BACKGROUNDnExposure to bacterial products in early life could protect against development of atopy. We examined the effect of bacterial lipopolysaccharide on allergic inflammation and expression of cytokines and lipopolysaccharide receptor (toll-like receptor 4 TLR4) in nasal mucosa of 15 atopic children and ten atopic adults.nnnMETHODSnExplanted mucosa was cultured with allergen with or without lipopolysaccharide (0.1 mg/L) for 24 h. Immunocytochemistry and in-situ hybridisation were used to phenotype the cells and cytokines.nnnFINDINGSnIn explants from atopic children, lipopolysaccharide prevented allergen-induced T-helper type 2 (Th2) inflammation and upregulated Th1 cytokine reactivity and expression. These effects were blocked by antibody to interleukin 10. In children but not in adults, lipopolysaccharide caused increases of three times in T-cell reactivity, five times in T-cell proliferation, and four times in expression of interleukin 10 compared with mucosa stimulated with allergen alone. This difference in response was mirrored by lipopolysaccharide-induced increases in TLR4 reactivity in children but not adults. TLR4 receptor was expressed by CD3-positive T cells, and TLR4-positive cells contained interleukin 10. Lipopolysaccharide increased expression of cells positive for both CD3 and TLR4; both TLR4 and interleukin 10; and both CD4 and CD25.nnnINTERPRETATIONnLipopolysaccharide inhibits allergic inflammation in nasal mucosa of atopic children by skewing local immune responses from Th2 to Th1 and upregulating production of interleukin 10. These effects are mediated by TLR4. Our results emphasise an important difference between adults and children in their ability to respond to bacterial products. These differences could have a role in normal maturation of the immune system.
American Journal of Respiratory and Critical Care Medicine | 2000
Alexandre Duguet; Keltoum Biyah; Eleanor M. Minshall; R. F. M. Gomes; Chong-Gang Wang; Majda Taoudi-Benchekroun; Jason H. T. Bates; David H. Eidelman
American Journal of Respiratory and Critical Care Medicine | 2001
Hiroaki Iijima; Alexandre Duguet; Seok-Yong Eum; Qutayba Hamid; David H. Eidelman
American Journal of Physiology-lung Cellular and Molecular Physiology | 2005
Seok-Yong Eum; Karim Maghni; Barbara Tolloczko; David H. Eidelman; James G. Martin
American Journal of Respiratory Cell and Molecular Biology | 2003
Seok-Yong Eum; Karim Maghni; Qutayba Hamid; Holly Campbell; David H. Eidelman; James G. Martin
American Journal of Respiratory and Critical Care Medicine | 2001
Alexandre Duguet; Hiroaki Iijima; Seok-Yong Eum; Qutayba Hamid; David H. Eidelman
The Journal of Allergy and Clinical Immunology | 2000
Yutaka Nakamura; Pota Christodoulopoulos; Lisa Cameron; Erin D. Wright; François Lavigne; Masao Toda; Shigeo Muro; Anuradha Ray; David H. Eidelman; Eleanor M. Minshall; Qutayba Hamid
Chest | 1995
Ronald J. Dandurand; Paul M. Matthews; Douglas L. Arnold; David H. Eidelman
Canadian Journal of Physiology and Pharmacology | 1997
Eleanor M. Minshall; Chong-Gang Wang; Ron J. Dandurand; David H. Eidelman