David H. Rosenberg

Comparison of the cephalin-cholesterol flocculation test with various criteria of liver function

1. The results of the cephahn-cholesterol flocculation test in 100 patients with clinical evidence of mild and moderate grades of liver disease are compared with the bromsulphthalein and hippuric acid tests, serum albumin and globulin fractions, prothrombin time, icterus index and serum cholesterol partition. 2. The cephalin-cholesterol flocculation test gave by far the best correlation with the clinical observations, and was positive in 98 of the 100 patients. In 10 patients the flocculation test was positive when all the other tests or combinations of tests were negative. Analysis of our results indicates that the flocculation test is an index of active parenchymal damage, rather than a measure of residual function. The interpretation of negative and slight flocculation reactions is discussed in the light of these observations. 3. Bromsulphthalein retention was found in 68 per cent of the cases; decreased hippuric acid excretion in 25 per cent; hyperexcretion of hippuric acid in 39 per cent; hypoalbuminemia in 47 per cent; decreased prothrombin in 37 per cent; elevated icterus index in 34 per cent; and decreased cholesterol esters in 20 per cent. 4. The many instances of hyperexcretion of hippuric acid observed in our cases of mild to moderate forms of liver disease indicate that this is not a normal phenomenon. It may be regarded as a manifestation of the hyperirritability of the liver, which is the earliest accompaniment of liver damage.

A Proved Case Of Recovery From Fatty Metamorphosis Of The Liver After Treatment With Lipocaic

A proved instance of recovery from fatty metamorphosis of the liver associated with diabetes mellitus following treatment with lipocaic is recorded. Biopsy studies made before and after treatment were correlated with the results of liver function and glucose tolerance tests, cholesterol determinations and with the clinical course. The changes observed represent the clinical counterpart of the findings noted in experimental animals.

Gastric ulcers associated with cinchophen poisoning

An instance of cinchophen poisoning associated with gastric ulcers is reported and another case is collected from the literature. The probability of cinchophen acting as the etiologic agent is suggested and discussed. Attention is directed to the need of further clinical and roentgenologic studies of the stomach and duodenum of patients who exhibit cinchophen poisoning. It is suggested that a carefulanamnesis in all peptic ulcer patients from the stand-point of cinchophen therapy might yield interesting data.

THE AZORUBIN S TEST OF LIVER FUNCTION; AN EVALUATION, WITH A COMPARATIVE STUDY OF THE BROMSULPHALEIN AND HIPPURIC ACID TESTS

Excerpt Few tests of liver function have proved to be of much value in the diagnosis and prognosis of diseases of this organ. Common to all is the failure to detect hepatic disease in its earlier s...

Macrocytic anemia in diseases of the liver: General considerations

The incidence, course, prognostic significance, pathologic findings, treatment and pathogenesis of the macrocytic anemia occurring in advanced or wide-spread liver disease are discussed. The similarities and dissimilarities to Addisonian pernicious anemia are reviewed. Attention is drawn to the importance of considering chronic liver disease, cirrhosis in particular, in the differential diagnosis of mild and moderate grades of Addisonian “pernicious” anemia.