David H. Weintraub

Changes in the fibrinolysin system during experimental pulmonary hyaline membrane formation in guinea pigs.

Summary Pulmonary hyaline membranes developed in guinea pigs exposed for several days to 95% oxygen at atmospheric pressures. This process was accompanied by increased antiplasmin activity in plasma and decreased pulmonary plasminogen activator activity. The latter phenomena may promote the formation of alveolar hyaline membranes by interfering with enzymatic removal of fibrin derived from pulmonary exudation. We wish to acknowledge the devoted assistance of G. Hauser, H. B. Lassman, I. B. Mink, and V. Zaniewski.

Resuscitation of the Newborn: A Résumé of Current Procedures

lungs and rapid oxygenization of the blood. So long as a newborn infant remains asphyxic with a lowered blood oxygen level and an elevated carbon dioxide tension, his asphyxia becomes more severe very rapidly. The blood oxygen level may drop severely, the carbon dioxide tension rises sometimes to as high as 155 nun. of mercury and blood pH falls usually below 7.1 Since these changes can occur within a matter of moments, it is most important to undertake resuscitation efforts with the greatest speed. For proper anticipation of the possible need for resuscitation in an infant who has not yet been delivered, follow the fetal heart rate during the terminal phases of delivery. Bradycardia with a rate dropping to 100 or below usually indicates asphyxia; this combined with passage of meconium in a vertex delivery

Mechanism of Renal Glycosuria in ACTH-Treated Premature Infants.

Conclusions Glycosuria resulting from ACTH administration in premature infants is due to an imbalance of glomerulotubular function demonstrated by a rise in GFR/TmG ratio. The cause of the rise in this ratio varied and was due either to a disproportionate rise in glomerular nitration rate or fall in glucose Tm. The nonglycosuric ACTH-treated infants did not show this rise in the GFR/TmG ratio.