David Ishai
Technion – Israel Institute of Technology
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Publication
Featured researches published by David Ishai.
Fertility and Sterility | 2003
Shirly Lahav-Baratz; Zaki Kraiem; Hanna Shiloh; Mara Koifman; David Ishai; Martha Dirnfeld
OBJECTIVE To compare activity of matrix metalloproteinases (MMP) and expression of their tissue-specific inhibitor (TIMP) in the follicular fluid of normally ovulating women and women with the polycystic ovary syndrome (PCOS). DESIGN Prospective study. SETTING IVF unit and endocrine research unit. PATIENT(S) Fourteen patients undergoing IVF treatment (seven with normal ovulation and seven with PCOS). MAIN OUTCOME MEASURE(S) Activity of MMP-2 and MMP-9 and expression of MMP-1, TIMP-1, and TIMP-2 was measured in follicular fluid of the leading follicles by using gel zymography and immunoblot analysis. RESULT(S) The activity of MMP-2 and MMP-9 and expression of MMP-1 was similar in follicular fluid of normally ovulating patients and patients with PCOS. Significantly lower expression of TIMP-1 was found in follicular fluid of patients with PCOS women compared with normally ovulating patients. CONCLUSION(S) Because MMPs and TIMPs play a role in the physical and chemical structure of the follicular compartment, the decreased expression of TIMP in patients with PCOS may be part of a compensatory process to overcome the physical properties of the thick ovarian capsule.
Journal of Assisted Reproduction and Genetics | 2003
Shirly Lahav-Baratz; Mara Koifman; H. Shiloh; David Ishai; Zofnat Wiener-Megnazi; Martha Dirnfeld
AbstractPurpose: In recent years the infertile population applying for IVF treatments was changed and so the indications for performing intracellular sperm injection (ICSI). The aim of this study was to analyze predicting factors of our thawing cycles. Methods: From December 1998 to July 2001, 440 consecutive thawing cycles were performed. Patient characteristics were examined. The number of cryopreserved embryos, number of transferred embryos, the timing of cryopreservation (48 h vs.72 h), and embryo survival rate were analyzed as a possible predictor for pregnancies achievement. Results: Conventional IVF patients characteristic was significantly different from ICSI population and analysis has been performed for every population separately. In the IVF population the women age, the number of transferred embryos, and timing of cryopreservation were factors significantly influencing the pregnancy rate. Interestingly, in the ICSI population only the number of transferred embryos was found to be a predictive factor. Conclusion: ICSI and IVF cycles should be analyzed separately. Not all the factors influencing the success rate in the conventional IVF population are valid in the ICSI population.
Fertility and Sterility | 2004
Zofnat Wiener-Megnazi; Liad Vardi; Arie Lissak; Sergei Shnizer; Abraham Z. Reznick; David Ishai; Shirly Lahav-Baratz; Hanna Shiloh; Mara Koifman; Martha Dirnfeld
Human Reproduction | 2004
Hanna Shiloh; S.Lahav Baratz; Mara Koifman; David Ishai; D. Bidder; Z. Weiner‐Meganzi; Martha Dirnfeld
Fertility and Sterility | 2004
Arie Lissak; Zofnat Wiener-Megnazi; Abraham Z. Reznick; Sergei Shnizer; David Ishai; Bronislava Grach; Shirly Lahav-Baratz; Hanna Shiloh; Mara Koifman; Martha Dirnfeld
Fertility and Sterility | 2004
Shirly Lahav-Baratz; Hanna Shiloh; Mara Koifman; Zaki Kraiem; Zofnat Wiener-Megnazi; David Ishai; Martha Dirnfeld
Fertility and Sterility | 2000
I Calderon; E Rothschild; Y Giladi; Martha Dirnfeld; David Ishai; Haim Abramovici
Journal of Assisted Reproduction and Genetics | 2016
Zofnat Wiener-Megnazi; Shirly Lahav-Baratz; Idit Blais; Sarah Matarasso; Mara Koifman; Sergei Shnizer; David Ishai; Gil Peer; Grace Younes; Ariel Zilberlicht; Ron Auslander; Martha Dirnfeld
Advances in Reproductive Sciences | 2014
Mara Koifman; Shirly Lahav-Baratz; Libby Shopen; Blais Idit; David Ishai; Zofnat Wiener-Megnazi; Ron Auslender; Martha Dirnfeld
Fertility and Sterility | 2002
Zofnat Wiener Megnazi; Bronislava Grach; David Ishai; Sergei Schnizer; Shirly Lahav Baratz; Martha Dirnfeld