David J. T. Marco

Consonance and pitch.

To date, no consensus exists in the literature as to theories of consonance and dissonance. Experimental data collected over the last century have raised questions about the dominant theories that are based on frequency relationships between the harmonics of music chords. This study provides experimental evidence that strongly challenges these theories and suggests a new theory of dissonance based on relationships between pitch perception and recognition. Experiment 1 shows that dissonance does not increase with increasing numbers of harmonics in chords as predicted by Helmholtzs (1863/1954) roughness theory, nor does it increase with fewer pitch-matching errors as predicted by Stumpfs (1898) tonal fusion theory. Dissonance was strongly correlated with pitch-matching error for chords, which in turn was reduced by chord familiarity and greater music training. This led to the proposition that long-term memory templates for common chords assist the perception of pitches in chords by providing an estimate of the chord intervals from spectral information. When recognition mechanisms based on these templates fail, the spectral pitch estimate is inconsistent with the period of the waveform, leading to cognitive incongruence and the negative affect of dissonance. The cognitive incongruence theory of dissonance was rigorously tested in Experiment 2, in which nonmusicians were trained to match the pitches of a random selection of 2-pitch chords. After 10 training sessions, they rated the chords they had learned to pitch match as less dissonant than the unlearned chords, irrespective of their tuning, providing strong support for a cognitive mechanism of dissonance.

Mind the gap: Multiple events and lengthy delays before presentation with a "first seizure".

Up to half of patients assessed for suspected new‐onset epileptic seizures report previous undiagnosed events. This suggests that delay to timely and expert assessment is a major issue. Very little is known about the degree of delay or nature of the undiagnosed events, impacting on our understanding of new‐onset epilepsy. In this study we aimed to examine events that occur before presentation, as well as the extent and risk factors for delay to assessment.

The musical environment and auditory plasticity: hearing the pitch of percussion

Although musical skills clearly improve with training, pitch processing has generally been believed to be biologically determined by the behavior of brain stem neural mechanisms. Two main classes of pitch models have emerged over the last 50 years. Harmonic template models have been used to explain cross-channel integration of frequency information, and waveform periodicity models have been used to explain pitch discrimination that is much finer than the resolution of the auditory nerve. It has been proposed that harmonic templates are learnt from repeated exposure to voice, and so it may also be possible to learn inharmonic templates from repeated exposure to inharmonic music instruments. This study investigated whether pitch-matching accuracy for inharmonic percussion instruments was better in people who have trained on these instruments and could reliably recognize their timbre. We found that adults who had trained with Indonesian gamelan instruments were better at recognizing and pitch-matching gamelan instruments than people with similar levels of music training, but no prior exposure to these instruments. These findings suggest that gamelan musicians were able to use inharmonic templates to support accurate pitch processing for these instruments. We suggest that recognition mechanisms based on spectrotemporal patterns of afferent auditory excitation in the early stages of pitch processing allow rapid priming of the lowest frequency partial of inharmonic timbres, explaining how music training can adapt pitch processing to different musical genres and instruments.

Pitch Enumeration: Failure to Subitize in Audition

Background Subitizing involves recognition mechanisms that allow effortless enumeration of up to four visual objects, however despite ample resolution experimental data suggest that only one pitch can be reliably enumerated. This may be due to the grouping of tones according to harmonic relationships by recognition mechanisms prior to fine pitch processing. Poorer frequency resolution of auditory information available to recognition mechanisms may lead to unrelated tones being grouped, resulting in underestimation of pitch number. Methods, Results and Conclusion We tested whether pitch enumeration is better for chords of full harmonic complex tones, where grouping errors are less likely, than for complexes with fewer and less accurately tuned harmonics. Chords of low familiarity were used to mitigate the possibility that participants would recognize the chord itself and simply recall the number of pitches. We found that accuracy of pitch enumeration was less than the visual system overall, and underestimation of pitch number increased for stimuli containing fewer harmonics. We conclude that harmonically related tones are first grouped at the poorer frequency resolution of the auditory nerve, leading to poor enumeration of more than one pitch.

Pitch and plasticity: insights from the pitch matching of chords by musicians with absolute and relative pitch.

Absolute pitch (AP) is a form of sound recognition in which musical note names are associated with discrete musical pitch categories. The accuracy of pitch matching by non-AP musicians for chords has recently been shown to depend on stimulus familiarity, pointing to a role of spectral recognition mechanisms in the early stages of pitch processing. Here we show that pitch matching accuracy by AP musicians was also dependent on their familiarity with the chord stimulus. This suggests that the pitch matching abilities of both AP and non-AP musicians for concurrently presented pitches are dependent on initial recognition of the chord. The dual mechanism model of pitch perception previously proposed by the authors suggests that spectral processing associated with sound recognition primes waveform processing to extract stimulus periodicity and refine pitch perception. The findings presented in this paper are consistent with the dual mechanism model of pitch, and in the case of AP musicians, the formation of nominal pitch categories based on both spectral and periodicity information.

Predictors of new-onset chronic kidney disease in patients managed surgically for T1a renal cell carcinoma: an Australian population-based analysis

New‐onset chronic kidney disease (CKD) following surgical management of kidney tumors is common. This study evaluated risk factors for new‐onset CKD after nephrectomy for T1a renal cell carcinoma (RCC) in an Australian population‐based cohort.

Trends in the surgical management of Stage 1 Renal Cell Carcinoma: findings from a population-based study

To determine whether the use of nephron‐sparing surgery (NSS) for treatment of stage 1 renal cell carcinoma (RCC) changed between 2009 and the end of 2013 in Australia.

Integrating referral to community-based cancer information and support services in a hospital setting

PurposeTo implement and evaluate a hospital-based referral mechanism to increase patient uptake of community-based cancer information and support services. Feasibility and acceptability of the intervention and education program was evaluated. Changes in usage of Cancer Council Victoria’s cancer information and support telephone line were investigated.MethodsA 6-month study was conducted in one metropolitan and one regional cancer treatment hospital. Clinicians attended an education session regarding referral mechanisms to Cancer Council support services. Clinicians completed a questionnaire, and consenting patients participated in a semi-structured telephone interview for the project evaluation. The number of calls made from patients at study sites was monitored.ResultsFifty-two clinicians were trained and referred a total of 430 patients to the cancer information and support service during the study period. Calls from patients increased by up to 100% per month from baseline following the implementation of the referral mechanism. Staff evaluations showed support for the referral mechanism and its incorporation into routine practice. Interviews were conducted with 45 patients; most remembered receiving the referral and were positive towards the intervention. Common reasons patients gave for not acting on the referral included forgetting, lack of need, timing and burden of information.ConclusionsThere is preliminary evidence that this intervention increases awareness and uptake of community-based cancer information and support services. Ongoing clinician education and improvements in patient-clinician communication are important for effective translation from referral to service uptake. Consideration of the most appropriate time in a patients’ care trajectory to introduce a referral is warranted.

Age at diagnosis and the surgical management of small renal carcinomas: findings from a cross-sectional population-based study

To describe the use of partial nephrectomy (PN) for patients with stage T1a renal cell carcinoma (RCC) by age group (<65 and ≥65 years) in two Australian states.