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David John Dunstone

University of Cambridge

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Bioorganic & Medicinal Chemistry Letters | 1993

2-NAP: a selective, hydrophilic, non-peptide CCKA - receptor antagonist derived from the cholecystokinin C-terminal dipeptide.

Iain Mair Mcdonald; Howard B. Broughton; David John Dunstone; S. Barret Kalindjian; Caroline M.R. Low

Abstract Analogues of the cholecystokinin (CCK) C-terminal dipeptide (32-33, Asp-Phe-NH 2 ) have been prepared and the structure-activity relationships of this series are described. The sodium salt of 2-naphthalenesulphonyl L-aspartyl (2-phenethyl)amide, (2-NAP), displayed high affinity for CCK A receptors by its antagonism of CCK 8 -stimulated guinea-pig gallbladder contraction. In addition, 2-NAP exhibits selectivity with respect to gastrin/CCK B receptors ( > 300-fold) and has a low log P (−0.91, chloroform/buffer).

Archive | 1994

Gastrin and cck receptor ligands

Sarkis Barret Kalindjian; Katherine Isobel Mary Steel; Michael John Pether; Jonathan Michael Richard Davies; Caroline M. R. Low; Martin L. Hudson; Ildiko Maria Buck; Iain Mair Mcdonald; David John Dunstone; Matthew J. Tozer

Journal of Medicinal Chemistry | 2007

Discovery and characterization of novel, potent, non-peptide parathyroid hormone-1 receptor antagonists.

Iain Mair Mcdonald; Carol Austin; Ildiko Maria Buck; David John Dunstone; John Gaffen; Eric Griffin; Elaine Anne Harper; Robert A. D. Hull; S. Barret Kalindjian; Ian D. Linney; Caroline M. R. Low; Dipa Patel; Michael John Pether; Michelle Raynor; Sonia P. Roberts; Mark E. Shaxted; John Spencer; Katherine Isobel Mary Steel; David A. Sykes; Paul T. Wright; Wei Xun

Journal of Medicinal Chemistry | 1996

Non-peptide cholecystokinin-B/gastrin receptor antagonists based on bicyclic, heteroaromatic skeletons.

S. B. Kalindjian; Ildiko Maria Buck; Jonathan Michael Richar Davies; David John Dunstone; Martin L. Hudson; Caroline M. R. Low; Iain Mair Mcdonald; Michael John Pether; Katherine Isobel Mary Steel; Matthew J. Tozer; J. G. Vinter

Journal of Medicinal Chemistry | 2000

2,7-Dioxo-2,3,4,5,6,7-hexahydro-1H-benzo[h][1,4]diazonine as a new template for the design of CCK(2) receptor antagonists.

Iain Mair Mcdonald; David John Dunstone; S. Barret Kalindjian; Ian D. Linney; Caroline M. R. Low; Michael John Pether; Katherine Isobel Mary Steel; Matthew J. Tozer; Jeremy G. Vinter

Journal of Medicinal Chemistry | 2006

Novel, Achiral 1,3,4-Benzotriazepine Analogues of 1,4-Benzodiazepine-Based CCK2 Antagonists That Display High Selectivity over CCK1 Receptors

Iain Mair Mcdonald; Carol Austin; Ildiko Maria Buck; David John Dunstone; Eric Griffin; Elaine Anne Harper; Robert A. D. Hull; S. Barret Kalindjian; Ian D. Linney; Caroline M. R. Low; Michael John Pether; John Spencer; Paul T. Wright; and Trushar Adatia; Alan Bashall

Journal of Medicinal Chemistry | 2007

Optimization of 1,3,4-benzotriazepine-based CCK2 antagonists to obtain potent, orally active inhibitors of gastrin-mediated gastric acid secretion

Iain Mair Mcdonald; James W. Black; Ildiko Maria Buck; David John Dunstone; Eric Griffin; Elaine Anne Harper; Robert A. D. Hull; S. Barret Kalindjian; Elliot J. Lilley; Ian D. Linney; Michael John Pether; Sonia P. Roberts; Mark E. Shaxted; John Spencer; Katherine Isobel Mary Steel; David A. Sykes; Martin K. Walker; Gillian Fairfull Watt; Laurence Wright; Paul T. Wright; Wei Xun

Archive | 1995

CCK and gastrin receptor ligands

Sarkis Barret Kalindjian; Katherine Isobel Mary Steel; David John Dunstone; Ildiko Maria Buck

Journal of Medicinal Chemistry | 2000

Development of peptide 3D structure mimetics: rational design of novel peptoid cholecystokinin receptor antagonists.

Caroline M. R. Low; James W. Black; Howard B. Broughton; Ildiko Maria Buck; Jonathan Michael Richar Davies; David John Dunstone; Robert A. D. Hull; S. Barret Kalindjian; Iain Mair Mcdonald; Michael John Pether; and Nigel P. Shankley; Katherine Isobel Mary Steel

Journal of Medicinal Chemistry | 2001

Nonpeptide cholecystokinin-2 receptor agonists.

S. Barret Kalindjian; David John Dunstone; Caroline M. R. Low; Michael John Pether; Sonia P. Roberts; Matthew J. Tozer; Gillian Fairfull Watt; Nigel P. Shankley

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Iain Mair Mcdonald

University of Cambridge

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Caroline M. R. Low

University of Liverpool

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Ildiko Maria Buck

Astex

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Matthew J. Tozer

Imperial College London

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S. Barret Kalindjian

University of Liverpool

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Robert A. D. Hull

King's College

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John Spencer

University of Sussex

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Sonia P. Roberts

King's College

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Martin L. Hudson

Kennesaw State University

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David A. Sykes

University of Nottingham

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