David L. Arendsen
Howard Hughes Medical Institute
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Biochemical and Biophysical Research Communications | 1983
L.M. Fredrik Leeb-Lundberg; K. E. J. Dickinson; Sarah L. Heald; Jarl E.S. Wikberg; John F. DeBernardis; Marty Winn; David L. Arendsen; Robert J. Lefkowitz; Marc G. Caron
A novel high affinity radioiodinated photoaffinity probe, 4-amino-6,7-dimethoxy-2[4-[5(3-[125I]iodo-4-azidophenyl)pentanoyl]-1- piperazinyl]-quinazoline, structurally related to the potent alpha 1-adrenergic antagonist prazosin, was developed and used to covalently label the rat cerebral cortex alpha 1-adrenergic receptor. In the absence of light, this ligand binds to cortex plasma membranes with a dissociation constant of 308 pM and with a maximal number of binding sites of 200 fmol/mg protein. Upon photolysis, the ligand incorporates irreversibly into plasma membrane proteins. Autoradiograms of such membrane samples subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis reveal a major specifically labeled polypeptide at Mr = 79,000. The covalent incorporation into the peptide at Mr = 79,000 can be inhibited by several adrenergic receptor ligands with a typical alpha 1-adrenergic receptor specificity and stereoselectivity.
Archive | 1999
Andrew O. Stewart; Steven Armen Boyd; David L. Arendsen; Pramila Bhatia; Kevin Ronald Condroski; Jennifer C. Freeman; Indrani W. Gunawardana; Gui-Dong Zhu; Kraig Lartey; Catherine M. Mccarty; Nicholas A. Mort; Meena V. Patel; Michael A. Staeger; David M. Stout
Archive | 1996
David L. Arendsen; William R. Baker; Stephen A. Fakhoury; K. L. Anthony Fung; David S. Garvey; William J. McClellan; Stephen J. O'connor; Rajnandan N. Prasad; Todd W. Rockway; Saul H. Rosenberg; Herman H. Stein; Wang Shen; David M. Stout; Gerard M. Sullivan; David J. Augeri
Journal of Medicinal Chemistry | 2001
Andrew O. Stewart; Pramila Bhatia; Catherine M. Mccarty; Meena Patel; Michael A. Staeger; David L. Arendsen; Indrani W. Gunawardana; Laura Melcher; Gui-Dong Zhu; Steven A. Boyd; Dennis G. Fry; Barbara L. Cool; Lemma Kifle; Kraig Lartey; Kennan C. Marsh; Anita J. Kempf-Grote; Patrick Kilgannon; Wendy Wisdom; Joey Meyer; and W. Michael Gallatin; Gregory F. Okasinski
Journal of Medicinal Chemistry | 2001
Gui-Dong Zhu; David L. Arendsen; Indrani W. Gunawardana; Steven A. Boyd; Andrew O. Stewart; Dennis G. Fry; Barbara L. Cool; Lemma Kifle; Verlyn G. Schaefer; Joseph L. Meuth; Kennan C. Marsh; Anita J. Kempf-Grote; Patrick D. Kilgannon; W. Michael Gallatin; Gregory F. Okasinski
Journal of Medicinal Chemistry | 1985
John F. DeBernardis; Daniel J. Kerkman; Martin Winn; Eugene N. Bush; David L. Arendsen; William J. McClellan; John J. Kyncl; Fatima Z. Basha
Journal of Medicinal Chemistry | 1997
Michael D. Meyer; Arthur A. Hancock; Karin Tietje; Kevin B. Sippy; Rajnandan N. Prasad; David M. Stout; David L. Arendsen; and B. Greg Donner; William A. Carroll
Journal of Medicinal Chemistry | 1987
John F. DeBernardis; David L. Arendsen; John J. Kyncl; Daniel J. Kerkman
Journal of Medicinal Chemistry | 1987
John F. DeBernardis; Daniel J. Kerkman; David L. Arendsen; Steve Buckner; John J. Kyncl; Arthur A. Hancock
Archive | 1989
John F. DeBernardis; David L. Arendsen; Robert Edward Zelle