David Lindsey Soper | Researchain

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Featured researches published by David Lindsey Soper.

Bioorganic & Medicinal Chemistry Letters | 2000

Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues

Mitchell Anthony Delong; Jack S. Amburgey; Cynthia J. Taylor; John August Wos; David Lindsey Soper; Yili Wang; Renee Hicks

The in vitro evaluation of a series of saturated prostaglandins revealed that compounds with omega chain aromatic rings retain nanomolar potency for the human prostaglandin F receptor (hFP receptor), exemplified by compound 8. In contrast, the double bonds are required for activity in the series with an acyclic omega chain as in PGF2alpha.

Phosphorus Sulfur and Silicon and The Related Elements | 2002

The Rational Design of Drugs with Phos-phonic/phinic Acids as Enzyme Inhibitors Isosteric Receptor Ligands

Frank H. Ebetino; David Lindsey Soper; Michelle J. Dirr; Mark Walden Lundy; Glen E. Mieling; John August Wos; Mitchell Anthony Delong; Xuewei Liu

Phosphonic/phosphinic acid analogs have been studied for inhibitory and ligand activity in farnesyl pyrophosphate synthase, prostaglandin, and other GPCRs.

Chemical & Pharmaceutical Bulletin | 2000

The Synthesis and Human FP Receptor Binding Affinity of 13, 14-Dihydro Prostaglandin F1α Sulfonamides : Potential Treatments for Osteoporosis

Yili Wang; David Lindsey Soper; Michelle J. Dirr; Mitchell Anthony Delong; Biswanath De; John August Wos

Journal of Medicinal Chemistry | 2000

Design and synthesis of 13,14-dihydro prostaglandin F1αanalogues as potent and selective ligands for the human fp receptor

Yili Wang; John August Wos; Michelle J. Dirr; David Lindsey Soper; Mitchell Anthony Delong; Glen E. Mieling; Biswanath De; Jack S. Amburgey; Eric Suchanek; Cynthia J. Taylor

Bioorganic & Medicinal Chemistry | 2007

Synthesis and evaluation of unsaturated caprolactams as interleukin-1β converting enzyme (ICE) inhibitors

Yili Wang; Steven V. O’Neil; John August Wos; Kofi A. Oppong; Michael C. Laufersweiler; David Lindsey Soper; Christopher D. Ellis; Mark William Baize; Amy N. Fancher; Wei Lu; Maureen K. Suchanek; Richard L. Wang; William P. Schwecke; Charles A. Cruze; Maria Buchalova; Marina Belkin; Biswanath De; Thomas P. Demuth

Bioorganic & Medicinal Chemistry Letters | 2005

Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme inhibitors

Steven V. O’Neil; Yili Wang; Michael C. Laufersweiler; Kofi A. Oppong; David Lindsey Soper; John August Wos; Christopher D. Ellis; Mark William Baize; Gregory Kent Bosch; Amy N. Fancher; Wei Lu; Maureen K. Suchanek; Richard L. Wang; Biswanath De; Thomas P. Demuth

Journal of Medicinal Chemistry | 2001

Synthesis and Biological Evaluation of Prostaglandin-F Alkylphosphinic Acid Derivatives as Bone Anabolic Agents for the Treatment of Osteoporosis.

David Lindsey Soper; Jared B. J. Milbank; Glen E. Mieling; Michelle J. Dirr; Andrew S. Kende; Robin D. G. Cooper; Webster S. S. Jee; Wei Yao; Jian Liang Chen; Mark Bodman; Mark Walden Lundy; Biswanath De; Mark Edward Stella; Frank H. Ebetino; Yili Wang; Mitchell Anthony Delong; John August Wos

Archive | 2000

C16 unsaturated fp-selective prostaglandins analogs

Mitchell Anthony Delong; David Lindsey Soper; John August Wos; Biswanath De

Archive | 2003

Derivatives of azepine and thiazepan as interleukin converting enzyme inhibitors

John August Wos; Ylil Wang; Kofi A. Oppong; Steven Victor O'neill; Michael C. Laufersweiler; David Lindsey Soper; Biswanath De; Thomas Posser Demuth

Bioorganic & Medicinal Chemistry | 2006

Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme (ICE) inhibitors

David Lindsey Soper; Justin Sheville; Steven V. O’Neil; Yili Wang; Michael C. Laufersweiler; Kofi A. Oppong; John August Wos; Christopher D. Ellis; Mark William Baize; Amy N. Fancher; Wei Lu; Maureen K. Suchanek; Richard L. Wang; William P. Schwecke; Charles A. Cruze; Maria Buchalova; Marina Belkin; Fred Christian Wireko; Amanda Ritter; Biswanath De; Difei Wang; Thomas P. Demuth

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