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David Miklos

Harvard University

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Featured researches published by David Miklos.

Cell | 1999

Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1

D.Paul Harkin; James Bean; David Miklos; Young-Han Song; Vivi Truong; Christoph Englert; Fred C. Christians; Leif W. Ellisen; Shyamala Maheswaran; Jonathan D Oliner; Daniel A. Haber

The breast cancer susceptibility gene BRCA1 encodes a protein implicated in the cellular response to DNA damage, with postulated roles in homologous recombination as well as transcriptional regulation. To identify downstream target genes, we established cell lines with tightly regulated inducible expression of BRCA1. High-density oligonucleotide arrays were used to analyze gene expression profiles at various times following BRCA1 induction. A major BRCA1 target is the DNA damage-responsive gene GADD45. Induction of BRCA1 triggers apoptosis through activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK), a signaling pathway potentially linked to GADD45 gene family members. The p53-independent induction of GADD45 by BRCA1 and its activation of JNK/SAPK suggest a pathway for BRCA1-induced apoptosis.

Biology of Blood and Marrow Transplantation | 2004

Sirolimus and tacrolimus without methotrexate as graft-versus-host disease prophylaxis after matched related donor peripheral blood stem cell transplantation

Corey Cutler; Haesook T. Kim; Ephraim P. Hochberg; Vincent T. Ho; Edwin P. Alyea; Stephanie J. Lee; David C. Fisher; David Miklos; Jesse Levin; Stephen T. Sonis; Robert J. Soiffer; Joseph H. Antin

Biology of Blood and Marrow Transplantation | 2004

Antibody response to H-Y minor histocompatibility antigens correlates with chronic graft versus host disease and disease remission

David Miklos; Haesook T. Kim; K.H. Miller; L. Guo; Emmanuel Zorn; Ephraim P. Hochberg; Stephanie J. Lee; Robert J. Soiffer; Joseph H. Antin; Jerome Ritz

Archive | 1998

Expression monitoring of downstream genes in the BRCA1 pathway

Jonathan D Oliner; Fred C. Christians; Vivi Truong; Da Haber; James Bean; David Miklos; Denis Paul Harkin

Archive | 2013

transplantation assessment of hematopoietic chimerism after allogeneic stem cell based method for - A novel rapid single nucleotide polymorphism (SNP)

Alex Mattes-Ritz; Edwin P. Alyea; Joseph H. Antin; Robert J. Soiffer; Jerome Ritz; Ephraim P. Hochberg; David Miklos; Donna Neuberg; Daniel A. Eichner; Stephen McLaughlin

Archive | 2013

transplantation disease prophylaxis in mismatched related donor or unrelated donor Sirolimus, tacrolimus, and low-dose methotrexate for graft-versus-host

Ephraim P. Hochberg; Catherine J. Wu; Edwin P. Alyea; Robert J. Soiffer; Joseph H. Antin; Haesook T. Kim; Corey Cutler; Vincent T. Ho; Stephanie J. Lee; David Miklos

Archive | 2010

after allogeneic stem cell transplantation and in healthy female donors Antibody response to DBY minor histocompatibility antigen is induced

Sebastien Viatte; Robert J. Soiffer; Joseph H. Antin; Jerome Ritz; David Miklos; Haesook T. Kim; Emmanuel Zorn; Ephraim P. Hochberg; Luxuan Guo

Clinical Immunology | 2006

OR.86. High Frequency CD4+ T‐Cell and Antibody Responses to H-Y Minor Histocompatibility Antigen DBY Following Allogeneic Hematopoietic Stem Cell Transplantation

Fabrice Porcheray; David Miklos; Blair Floyd; Stefanie Sarantopoulos; Roberto Bellucci; Edwin P. Alyea; Jerome Ritz; Emmanuel Zorn

Blood | 2004

Genetic Disparity between Stem Cell Transplant Patients and Their Donors Assessed by High Density Single Nucleotide Polymorphism (SNP) Microarray Typing Is Seen in Specific Genomic Regions.

Ephraim P. Hochberg; David Miklos; Emmanuel Zorn; Jesse Levin; Carol Reynolds; Christine Canning; Robert J. Soiffer; Jerome Ritz

Blood | 2004

The Y-Specific Gene PRY Is Expressed in Normal Blood Cells as Well as Leukemia Cells and Can Elicit a Specific Antibody Response in Male Recipients of Hematopoietic Stem Cells from Female Donors.

Emmanuel Zorn; Blair Floyd; Andrew Tweel; David Miklos; Roberto Bellucci; Christine Canning; Robert J. Soiffer; Joseph H. Antin; Jerome Ritz

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Ephraim P. Hochberg

Harvard University

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Joseph H. Antin

Northwestern University

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Haesook T. Kim

Tufts University

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Robert J. Soiffer

Queen Mary University of London

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Corey Cutler

Northwestern University

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Emmanuel Zorn

Columbia University Medical Center

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Jerome Ritz

Harvard University

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Stephanie J. Lee

Medical College of Wisconsin

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Robert J. Soiffer

Queen Mary University of London

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Edwin P. Alyea

Queen Mary University of London

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