David R. Gibson

Inherited deficiency of the second component of complement. Rheumatic disease associations.

The prevalence of homozygous and heterozygous deficiency of the second component of complement (C2) was determined in patients with rheumatic disease including 137 with systemic lupus erythematosus (SLE), 274 with juvenile rheumatoid arthritis, and 134 with rheumatoid arthritis. 1 C2 homozygous deficient and 19 possible heterozygous deficient individuals were identified by using both immunochemical and functional assays to determine C2 levels. Of the 20, 8 had SLE (5.9%), 10 had juvenile rheumatoid arthritis (3.7%), and 2 had rheumatoid arthritis (1.4%), the homozygous deficient individual having SLE. The prevalence of C2 deficiency in the SLE and juvenile rheumatoid arthritis patients was significantly increased (P = 0.0009 and P = 0.02, respectively) when compared with controls, 6 (1.2%) of 509 blood donors having C2 levels consistent with heterozygous deficiency. 15 of the 20 C2 deficient patients were HLA typed and found to have antigens A10(Aw25), B18, or both. The patients with C2 deficiency and SLE had earlier age of onset of disease and less antinuclear antibody when compared with the C2 normal SLE patients. 11 families of the propositi were studied and found to have one or more C2 heterozygous deficient individuals. The family members had an equal distribution of rheumatic disease and antinuclear antibody in the C2 deficient and C2 normal groups. C2 deficient individuals were found to have significantly lower levels of properdin Factor B (242 mug/ml+/-54) when compared with the non-C2 deficient family members (282 mug/ml+/-73). These data support the concept that inherited deficiency of C2 is significantly associated with both SLE and juvenile rheumatoid arthritis.

Taking Turns and Talking Ties: Networks and Conversational Interaction1

Conversational encounters are permeable to network effects but not entirely so, for conversation is internally structured by sequential constraints and dependencies that limit the latitude people have to act on their relational commitments. The author analyzes the effects of hierarchical (superior‐subordinate) and horizontal (friendship and co‐working) networks on “participation shifts”—transitions in the identities of speakers and targets (addressees) that occur from one speaking turn to the next—in meetings of 10 groups of managers. The results point to a range of relational obligations and entitlements, such as the obligation subordinates have to bolster superiors’ control of the floor, and the way in which friendship and co‐working ties get expressed through remarks made to third parties. The article is perhaps the first to link statistically network‐analytic and conversation‐analytic levels of analysis.

Concurrency and Commitment: Network Scheduling and Its Consequences for Diffusion 1

ABSTRACT Network ties are thought to be concurrent—one can “have” many friends at once, for instance—but their concrete enactment is largely serial and episodic, guided by priorities that steer a person from one encounter to the next. Further, dyadic encounters require that two people be simultaneously available to interact, creating the need for coordinated scheduling. Here I study the consequences of scheduling for network diffusion, using a computer simulation that interposes a scheduling process between a pre-existing network and instances of contagion. The pace and extent of diffusion are shown to depend upon the interaction of network topology, contagion rule (on first-contact versus at some threshold), and whether actors try to remedy past scheduling imperfections. Scheduling turns central actors into diffusion bottlenecks, but can also trigger early adoption by giving actors false readings on the status of their network alters. The implications of scheduling extend beyond diffusion, to other outcomes such as decision-making, as well as to network evolution.

Seizing the Moment: The Problem of Conversational Agency*

In conversation, actors face constraints on when they can speak, whom they can address, what they can say, and what they can safely expect from others by way of cooperation. This is the backdrop against which people pursue their idiosyncratic interests and objectives, success at which constitutes conversational agency. In principle, agency is made possible by the “looseness” of conversational constraints. This does not create a clear path for the advancement of personal ends, however, since options are always limited by the context, and success is always contingent upon the cooperation of others. Ultimately, the most agentic people are those who readily exploit imperfect options though this means abandoning the inflexible pursuit of pre-conceived objectives.

Avoiding Catastrophe: The Interactional Production of Possibility during the Cuban Missile Crisis1

In October 1962, the fate of the world hung on the U.S. response to the discovery of Soviet nuclear missiles in Cuba. President Kennedy’s decision to impose a blockade was based on hours of discussions with top advisers (the so-called ExComm), yet decades of scholarship on the crisis have missed the central puzzle: How did the group select one response, the blockade, when all options seemed bad? Recently released audio recordings are used to argue that the key conversational activity was storytelling about an uncertain future. Kennedy’s choice of a blockade hinged on the narrative “suppression” of its most dangerous possible consequence, namely the perils of a later attack against operational missiles, something accomplished through omission, self-censorship, ambiguation, uptake failure, and narrative interdiction. The article makes the very first connection between the localized dynamics of conversation and decision making in times of crisis, and offers a novel processual account of one of the most fateful decisions in human history.

Marking the Turn: Obligation, Engagement, and Alienation in Group Discussions

In group conversations, not speaking is the state of affairs experienced by most people most of the time; I refer to this as ‘‘conversational latency.’’ Hypothesizing that conversational latency affects one’s discursive options, I analyze the association between latency (operationalized as the number of turns that elapsed since the current speaker last spoke) and turn-initial words (e.g., but, oh) in twenty-nine experimental task groups, taking turn-initial words as indicators of the type of content a speaker proposes to produce. The findings suggest a model of group conversation in which conversational obligations weigh heaviest on the shoulders of the most recent contributors; those who contributed somewhat less recently remain engaged but have more latitude to take discordant positions; and those who have been quiet for longer periods are susceptible to ‘‘alienation from topic,’’ as a result of which reentry is often accompanied by an attempt to change the topic.

Opportunistic interruptions : Interactional vulnerabilities deriving from linearization

Speaking involves “linearizing” a message into a string of words. This process leaves us vulnerable to being interrupted in such a way that the aborted turn is a misrepresentation of the intended message. Further, because we linearize our messages in standard ways, we are recurrently vulnerable to interruptions at particular turn-construction junctures, and consequently to recurrent types of self-misrepresentation. These vulnerabilities can be exploited strategically when an interrupter responds to the truncated turn in a way that might not have been possible if the turn had run to completion: I refer to interruptions of this sort as “opportunistic.” I explore the connection between linearization and opportunistic interruptions using data from two institutional settings characterized by confrontational exchanges: Supreme Court oral arguments and Pentagon press briefings. The extracts illustrate how speakers open themselves to opportunistic interruptions through projection of incipient options, actions, reasons, consequences, opinions, and restrictions.

More than a Game: Sociological Theory from the Theories of Games*

Sociologists are fond of game metaphors. However, such metaphors rarely go beyond casual references to generic games. Yet games are little social systems, and each game offers a distinctive perspective on the relationship between rules and constraints, on the one side, and emergent order, on the other. In this article, we examine three games—chess, go, and (Texas hold ‘em) poker—for sociological insights into contested social arenas such as markets, warfare, politics, and the professions. We describe each games rules and emergent properties, and then offer a brief theorization of the social world through the “lens” of that game. Then we show how a study of the three games advances the sociology of strategy by enriching ideas about skill, position, and strategic dilemma.

Turn-Taking and Geopolitics in the Making of Decisions

President John F. Kennedy navigated through the Cuban missile crisis with the help of his advisers in the so-called ExComm. While ExComm attendance was very stable and its goal, the removal of the missiles, clear, true to the garbage can model the options available were socially constructed and were ambiguously related to the objective they purportedly served. An analysis of the recorded discussions reveals that Kennedys choice of a blockade required the ExComm to suppress talk about the perils it entailed; his decision not to intercept a Soviet tanker was based less on caution than unsustainable indecision; and when Kennedy squared off against his advisers regarding the best way to respond to Khrushchevs conflicting offers on October 26 and 27, the latter worked to exclude him from the very decision he was about to make. The analysis points to a natural affinity between the garbage can model and ethnomethodological attention to the fine-grained details of deliberative talk.