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David Robert Luthin

General Atomics

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Publication

Featured researches published by David Robert Luthin.

Bioorganic & Medicinal Chemistry Letters | 1999

Synthesis and biological activity of oxo-7H-benzo[e]perimidine-4-carboxylic acid derivatives as potent, nonpeptide corticotropin releasing factor (CRF) receptor antagonists.

David Robert Luthin; Aleksandr K. Rabinovich; Dilip R. Bhumralkar; Kenna L. Youngblood; Richard A. Bychowski; Daljit S. Dhanoa; John M. May

A novel series of derivatives of oxo-7H-benzo[e]perimidine-4-carboxylic acid (I) potently displaced radioligand binding of 125I-CRF to both CRF1 and CRF2 receptors. The members of this series antagonized CRF-stimulated cAMP formation and CRF-stimulated corticotropin release from rat pituitary in vivo. These are the first nonpeptide antagonists to show activity at both CRF1 and CRF2 receptors.

Journal of Pharmacology and Experimental Therapeutics | 2003

Biological Characterization of a Novel, Orally Active Small Molecule Gonadotropin-Releasing Hormone (GnRH) Antagonist Using Castrated and Intact Rats

Kenna Anderes; David Robert Luthin; Rosemary Castillo; Eugenia Kraynov; Mary Castro; Karen Nared-Hood; Margaret L. Gregory; Ved P. Pathak; Lance Christopher Christie; Genevieve Paderes; Haresh Vazir; Qiang Ye; Mark B. Anderson; John May

Archive | 1999

Non-peptide GnRH agents, methods and intermediates for their preparation

Mark B. Anderson; Haresh Vazir; David Robert Luthin; Genevieve Paderes; Ved P. Pathak; Lance Christopher Christie; Yufeng Hong; Eileen Valenzuela Tompkins; Haitao Li; James Faust

Archive | 1996

Benzoperimidine-carboxylic acids and derivatives thereof

Aleksandr K. Rabinovich; Dale S. Dhanoa; David Robert Luthin; Richard A. Bychowski; Dilip R. Bhumralkar

Journal of Medicinal Chemistry | 2006

Discovery of a novel, orally active, small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist

Haitao Li; Kenna Anderes; Eugenia Kraynov; David Robert Luthin; Quyen-Quyen T. Do; Yufeng Hong; Eileen Valenzuela Tompkins; Eric T. Sun; Ranjan Jagath Rajapakse; Ved P. Pathak; Lance Christopher Christie; Haresh Vazir; Rosemary Castillo; Margaret L. Gregory; Mary Castro; Karen Nared-Hood; and Genevieve Paderes; Mark B. Anderson

Archive | 2002

NON-PEPTIDE GnRH AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USES, AND PROCESSES FOR PREPARING THEM

Eric T. Sun; Mark B. Anderson; Kenna Anderes; Lance Christopher Christie; Quyen-Quyen T. Do; Jun Feng; Thomas Goetzen; Yufeng Hong; Eugenia A. Iatsimirskaia; Haitao Li; David Robert Luthin; Genevieve Paderes; Ved P. Pathak; Ranjan Jagath Rajapakse; Scott Shackelford; Eileen Valenzuela Tompkins; Larry Truesdale; Haresh Vazir

Archive | 2002

Aminoalkylpyrrolidine serotonin receptor ligands and compositions, their pharmaceutical uses, and methods for their synthesis

Yuanjin Rui; Atsuo Kuki; Yufeng Hong; Zhengwei Peng; David Robert Luthin

Archive | 2001

Amidino-urea serotonin receptor ligands and compositions, their pharmaceutical uses, and methods for their snythesis

Yufeng Hong; Atsuo Kuki; Eileen Valenzuela Tompkins; Zhengwei Peng; David Robert Luthin

Archive | 2001

Aminoalkylpyrrolidine als serotoninrezeptorliganden sowie diese enthaltende zusammensetzungen, pharmazeutische verwendungen und methoden zu deren synthese Aminoalkylpyrrolidine as serotonin receptor ligands and compositions containing them, pharmaceutical uses and methods for their synthesis

Yufeng San Diego Hong; Atsuo Kuki; David Robert Luthin; Zhengwei San Diego Peng; Yuanjin San Diego Rui

Archive | 2001

Ligands des recepteurs de serotonine aminoalkylpyrrolidine et compositions, leurs utilisations pharmaceutiques, et procedes pour leur synthese

Yuanjin Rui; Atsuo Kuki; Yufeng Hong; Zhengwei Peng; David Robert Luthin

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Collaboration

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Yufeng Hong

Pfizer

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Eileen Valenzuela Tompkins

Pfizer

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Haresh Vazir

Pfizer

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Lance Christopher Christie

Pfizer

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Mark B. Anderson

University of Michigan

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Ved P. Pathak

Pfizer

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Genevieve Paderes

Pfizer

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Haitao Li

Pfizer

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Atsuo Kuki

Pfizer

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Kenna Anderes

Pfizer

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