David Tejedor
Spanish National Research Council
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Featured researches published by David Tejedor.
Angewandte Chemie | 2010
Pedro de Armas; David Tejedor; Fernando García-Tellado
We thank the Spanish MCINN (CTQ2008‐06806‐C02‐02), MSC ISCIII (RETICS RD06/0020/1046) and FUNCIS (REDESFAC PI 01/06 and 35/06) for financial support.
Organic Preparations and Procedures International | 2004
David Tejedor; Fernando García-Tellado
INTRODUCTION ......................................................................................................................... 35 I SYNTHESIS OF TETRONIC ACIDS .................................................................................... 35 1 . Base-promoted Dieckman Cyclization .............................................................................. 35 2 . Cyclization of y-Hydroxylated or y-Halogenated P-Ketoester ........................................ 38 3 . Synthesis from Other Heterocycles .................................................................................... 41 4 . One-pot Synthesis ................................................................................................................. 42 II REACTIVITY OF TETRONIC ACIDS ................................................................................ 44 1.3-Acylation ............................................................................................................................ 44
Chemistry: A European Journal | 2010
David Tejedor; Gabriela Méndez-Abt; Fernando García-Tellado
This research was supported by the Spanish Ministerio de Ciencia e Innovacion, the European Regional Development Fund (CTQ2005-09074-C02-02 and CTQ2008-06806-C02-02) and the Spanish MSC ISCIII (RETICS, RD06/0020/1046, and RD06/0020/0041), CSIC (Proyecto Intramural Especial 200719), FUNCIS (REDESFAC PI01/06 and 35/06) and the Fundacion Instituto Canario de Investigacion del Cancer (FICI-G.I.N808/2007). G.M.-A. thanks Spanish MEC for a FPU grant.
Angewandte Chemie | 2009
David Tejedor; Sara López‐Tosco; Fabio Cruz‐Acosta; Gabriela Méndez-Abt; Fernando García-Tellado
Alkyl propiolates are reagents with a versatile reactivity profile that entirely remains in the C(3)-homologated product for further elaboration. To be effective, this C(3) homologation requires suitable methods for the generation of the acetylide anion that are compatible with both the conjugated ester and the electrophilic partner. Recent advances include catalytic procedures for the in situ generation of these acetylides in the presence of suitable electrophiles. Whereas the organometallic methods have brought stereoselectivity to these reactions, the organocatalytic methods laid the ground for new efficient domino processes that generate complexity.
Chemistry: A European Journal | 2011
David Tejedor; Gabriela Méndez-Abt; Leandro Cotos; Miguel A. Ramírez; Fernando García-Tellado
This research was supported by the Spanish MICINN and the European RDF (CTQ2008-06806-C02-01 and CTQ2008-06806-C02-02), the Spanish MSC ISCIII (RETICS RD06/0020/1046), FUNCIS (REDESFAC PI01/06). G.M.A. and L.C. thank the Spanish MEC for FPU and FPI grants, respectively. The authors thank Dr. T. Martin and Professor V. S. Martin for insightful discussions, Professor F. Cossio for mechanistic advice, and Anna Jurado for technical assistance.
Organic Letters | 2011
David Tejedor; Leandro Cotos; Fernando García-Tellado
Tertiary propargyl vinyl ethers armed with an electron-withdrawing group (amide or ester) at the tertiary propargylic position have been efficiently transformed into trisubstituted C(2)-chain functionalized furans. The metal-free domino transformation involves a microwave-assisted tandem [3,3]-propargyl Claisen rearrangement/5-exo-dig O-cyclization reaction. The manifold can be performed in a one-pot fashion from the primary components (1,2-ketoester/1,2-ketoamide or tertiary propargyl alcohols).
Chemistry: A European Journal | 2009
David Tejedor; Sara López‐Tosco; Javier González-Platas; Fernando García-Tellado
Authors thank the Spanish Ministerio de Educacion y Ciencia and the European Regional Development Fund (CTQ2005-09074-C02-02), the Spanish MSC ISCIII (RETICS RD06/0020/1046), CSIC (Proyecto Intramural Especial 200719) and Fundacion Instituto Canario de Investigacion del Cancer (FICI-G.I. No. 08/2007) for financial support. S.L.-T. Thanks MEC for a FPU grant.
Journal of Organic Chemistry | 2014
David Tejedor; Leandro Cotos; Gabriela Méndez-Abt; Fernando García-Tellado
A general and practical metal-free protocol for the synthesis of 1,2-dihydropyridines with wide structural/functional diversity at the ring and featuring mono, double, or spiro substitution at the sp(3) position is described. The protocol entails a microwave-assisted domino reaction of a propargyl vinyl ether (secondary or tertiary) and a primary amine (aliphatic or aromatic) in toluene or methanol.
Journal of Medicinal Chemistry | 2010
Leticia G. Leon; Carla Ríos-Luci; David Tejedor; Eduardo Pérez-Roth; Juan Carlos Montero; Atanasio Pandiella; Fernando García-Tellado; José M. Padrón
A small structure-focused library of propargylic enol ethers was prepared by means of a modular and efficient chemodifferentiating organocatalyzed multicomponent reaction. The most active compound (GI(50) 0.25 microM) against solid tumor cells was selected as lead. Cell cycle analysis and immunoblotting demonstrated arrest at the metaphase, pointing out human topoisomerase II as plausible molecular target. In vitro assays were carried out, showing that the lead behaves as a catalytic inhibitor of the enzyme.
Journal of Organic Chemistry | 2013
David Tejedor; Sara López‐Tosco; Fernando García-Tellado
A novel approach to the synthesis of fully substituted pyrimidine derivatives armed with an oxy-functionalized acetate chain at the ring is described. The manifold uses amidines as the nitrogen source and activated skipped diynes as the electrophilic reactive partners in a coupled domino strategy. In the first domino reaction, two consecutive aza-Michael additions assemble the six-membered ring heterocycle, while in the second domino process, a [H]-shift and a [3,3]-sigmatropic rearrangement lead to the aromatization of the product.