David W. Barron

EXPERIENCES WITH A NEW METHYL-THIOBARBITURATE: (B.137)

ANY ATTEMPTS have been made to M produce barbiturates with a shorte r duration of action than those in current use. These consist of methylation or ethylation in the N1 position, sulphuration in the C2 position, and disubstitution in the 5 and 5‘ positions. Changes in the 1 and 5 positions have been combined with success in hexobarbital and methohexital, while drugs in current standard use, such as thiopental, thialbarbitone, and t h i a m y l a l (SuritalB) have been produced by sulphuration and alteration of the alkyl side chains.