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Dive into the research topics where David W. Rodenbaugh is active.

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Featured researches published by David W. Rodenbaugh.


American Journal of Physiology-heart and Circulatory Physiology | 1998

Arterial baroreflex resetting mediates postexercise reductions in arterial pressure and heart rate

Margaret P. Chandler; David W. Rodenbaugh; Stephen E. DiCarlo

We tested the hypothesis that postexercise reductions in arterial pressure and heart rate (HR) are mediated by a lowering of the operating point and a reduction in the gain of the arterial baroreflex. To test this hypothesis, spontaneous changes in arterial pressure and the reflex responses of HR were examined before and after a single bout of mild to moderate dynamic exercise in 19 spontaneously hypertensive rats (SHR, 10 male and 9 female). Eleven SHR subjected to sinoaortic denervation (SAD) (6 male, 5 female) were also studied. All rats were instrumented with an arterial catheter for the measurement of arterial pressure and HR. After exercise, arterial pressure and HR were reduced below preexercise levels. Furthermore, the operating point and spontaneous gain (G) of the arterial baroreflex were reduced. Specifically, after exercise, the spontaneous range of HR (P1, 50%), the pressure at the midpoint of the pressure range (P3, 13%) and the HR at the midpoint of the HR range (H3, 10%), the spontaneous minimum HR (P4, 8%) and maximum HR (10%), and G (76%) were significantly attenuated. SAD significantly attenuated the relationship between arterial pressure and HR by reducing G (males 94%, females 95%). These results demonstrate that acute exercise resulted in a postexercise resetting of the operating point and a reduction in the gain of the arterial baroreflex. Furthermore, these data suggest that postexercise reductions in arterial pressure and HR are mediated by a lowering of the operating point of the arterial baroreflex.We tested the hypothesis that postexercise reductions in arterial pressure and heart rate (HR) are mediated by a lowering of the operating point and a reduction in the gain of the arterial baroreflex. To test this hypothesis, spontaneous changes in arterial pressure and the reflex responses of HR were examined before and after a single bout of mild to moderate dynamic exercise in 19 spontaneously hypertensive rats (SHR, 10 male and 9 female). Eleven SHR subjected to sinoaortic denervation (SAD) (6 male, 5 female) were also studied. All rats were instrumented with an arterial catheter for the measurement of arterial pressure and HR. After exercise, arterial pressure and HR were reduced below preexercise levels. Furthermore, the operating point and spontaneous gain (G) of the arterial baroreflex were reduced. Specifically, after exercise, the spontaneous range of HR (P1, 50%), the pressure at the midpoint of the pressure range (P3, 13%) and the HR at the midpoint of the HR range (H3, 10%), the spontaneous minimum HR (P4, 8%) and maximum HR (10%), and G (76%) were significantly attenuated. SAD significantly attenuated the relationship between arterial pressure and HR by reducing G (males 94%, females 95%). These results demonstrate that acute exercise resulted in a postexercise resetting of the operating point and a reduction in the gain of the arterial baroreflex. Furthermore, these data suggest that postexercise reductions in arterial pressure and HR are mediated by a lowering of the operating point of the arterial baroreflex.


American Journal of Physiology-regulatory Integrative and Comparative Physiology | 1998

Dynamic exercise shifts the operating point and reduces the gain of the arterial baroreflex in rats

Heather R. Burger; Margaret P. Chandler; David W. Rodenbaugh; Stephen E. DiCarlo

We tested the hypothesis that dynamic exercise resets the operating point and attenuates the gain of the arterial baroreflex regulation of heart rate (HR) in rats. Seven adult female spontaneously hypertensive rats (SHR) were chronically instrumented with left carotid arterial catheters. After the rats recovered, arterial baroreflex function was examined by recording reflex changes in HR in response to spontaneous changes in arterial pressure (AP) during a preexercise condition and during steady-state treadmill running at 6 and 18 m/min. Dynamic exercise at 6 and 18 m/min, respectively, reduced the spontaneous range (by 55 and 70%) and spontaneous gain (by 64 and 82%) of the arterial baroreflex control of HR. Dynamic exercise at 6 and 18 m/min, respectively, also increased the pressure at the midpoint of the spontaneous pressure range (by 7 and 12%), the spontaneous minimum HR response (by 35 and 59%), the HR at the midpoint of the spontaneous HR range (by 31 and 52%), and the spontaneous maximum HR response (by 27 and 46%). Sinoaortic denervation eliminated the relationship between AP and HR by reducing the spontaneous gain 95%. These results demonstrate that dynamic exercise shifted the operating point of the arterial baroreflex to a higher pressure and reduced the spontaneous gain in female SHR.We tested the hypothesis that dynamic exercise resets the operating point and attenuates the gain of the arterial baroreflex regulation of heart rate (HR) in rats. Seven adult female spontaneously hypertensive rats (SHR) were chronically instrumented with left carotid arterial catheters. After the rats recovered, arterial baroreflex function was examined by recording reflex changes in HR in response to spontaneous changes in arterial pressure (AP) during a preexercise condition and during steady-state treadmill running at 6 and 18 m/min. Dynamic exercise at 6 and 18 m/min, respectively, reduced the spontaneous range (by 55 and 70%) and spontaneous gain (by 64 and 82%) of the arterial baroreflex control of HR. Dynamic exercise at 6 and 18 m/min, respectively, also increased the pressure at the midpoint of the spontaneous pressure range (by 7 and 12%), the spontaneous minimum HR response (by 35 and 59%), the HR at the midpoint of the spontaneous HR range (by 31 and 52%), and the spontaneous maximum HR response (by 27 and 46%). Sinoaortic denervation eliminated the relationship between AP and HR by reducing the spontaneous gain 95%. These results demonstrate that dynamic exercise shifted the operating point of the arterial baroreflex to a higher pressure and reduced the spontaneous gain in female SHR.


Advances in Physiology Education | 2014

Having fun and accepting challenges are natural instincts: jigsaw puzzles to challenge students and test their abilities while having fun!

Hanna R. Rodenbaugh; Heidi L. Lujan; David W. Rodenbaugh; Stephen E. DiCarlo

crossword puzzles, hidden messages, word scrambles, word searches, card games, and “virtual” rats are used to motivate students, enhance their understanding of physiology, and foster logical thinking and problem-solving skills ([1][1], [5][2]–[7][3]). Similarly, jigsaw puzzles advance these


Advances in Physiology Education | 2008

Modeling the Anatomy and Function of the Pelvic Diaphragm and Perineal Body Using a “String Model”

B Satheesha Nayak; David W. Rodenbaugh

Understanding the attachment and function of the pelvic diaphragm and perineal body is important for gynecologists, gastroenterologists, surgeons, and other medical practitioners. The structure and function of the pelvic diaphragm are typically introduced to medical students in anatomy class during


Advances in Physiology Education | 2015

Maximize a team-based learning gallery walk experience: herding cats is easier than you think

David W. Rodenbaugh

team-based learning (TBL) is an instructional strategy that promotes small group learning and peer instruction in a large class environment ([5][1]). TBL is structured to include the following steps: 1 ) student preparation, e.g., reading/reviewing course lectures, and 2 ) readiness assurance


Advances in Physiology Education | 2003

STUDENT RETENTION OF COURSE CONTENT IS IMPROVED BY COLLABORATIVE-GROUP TESTING

Ronald N. Cortright; Heidi L. Collins; David W. Rodenbaugh; Stephen E. DiCarlo


Advances in Physiology Education | 2000

Who wants to be a physician? An educational tool for reviewing pulmonary physiology.

Justin R. Moy; David W. Rodenbaugh; Heidi L. Collins; Stephen E. DiCarlo


Advances in Physiology Education | 2002

Creating A Simple Powerpoint Multimedia Game

David W. Rodenbaugh; Heidi L. Collins; Stephen E. DiCarlo


Advances in Physiology Education | 2002

Experiment to Help Students Understand Pulmonary Compliance

Stephen E. DiCarlo; Heidi L. Collins; David W. Rodenbaugh


Advances in Physiology Education | 1999

An inquiry-based teaching tool for understanding arterial blood pressure regulation and cardiovascular function.

Heidi L. Collins; David W. Rodenbaugh; Todd P. Murphy; Jennifer M. Kulics; Cynthia M. Bailey; Stephen E. DiCarlo

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Stephen E. DiCarlo

Northeast Ohio Medical University

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Margaret P. Chandler

Case Western Reserve University

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Amy L. Morgan

Bowling Green State University

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Gina M. Story

Northeast Ohio Medical University

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