Davut Güven

Relation with postpartum maternal morbidity of different types of anesthesia in preeclamptic patients

ABSTRACT Objective: The aim of this study is to investigate the effect of different anesthesia types administered to patients with preeclampsia on postoperative maternal morbidities. Methods: Medical records of pregnant women complicated with preeclampsia delivered by cesarean from January 2010 to December 2016 in our clinic were retrospectively reviewed. Results: There was not a statistically significant difference between patients receiving spinal anesthesia and general anesthesia in terms of additional parenteral analgesic requirement at postoperative period (p = 0.520). The length of stay in hospital and δHb (preoperative hemoglobin value minus postoperative hemoglobin value) were not different between spinal anesthesia and general anesthesia groups (p = 0.140 and 0.648, respectively). The rate of postoperative antihypertensive medication requirement was statistically significant in patients with severe preeclampsia who underwent general anesthesia (p = 0.009, x2 = 6.867, odds ratios = 4.276 (1.531–11.942)). The time passing to reach the first normal blood pressure level in patients with severe preeclampsia was 11.95 ± 9.11 h in patients with spinal anesthesia, 10.55 ± 4.95 h in patients with general anesthesia, and the difference was not statistically significant (p = 0.504). Conclusion: The need for antihypertensive medication is greater in patients with severe preeclampsia receiving general anesthesia. There is a need for comprehensive, prospective, and randomized controlled trials to establish the relationship between postpartum morbidity and the different types of anesthesia.

Evaluation of progesterone levels during the luteal phase in athletes and sedentary individuals

ABSTRACT The aim of this study is to investigate the effect of regular exercise on progesterone levels during the luteal phase among basketball players and sedentary women. The study included a total of 34 individuals. Venous blood samples (4 cc) were collected from subjects on days 20 and 21 of the menstrual cycle. Based on the test results, a statistically significant difference was observed between active basketball players and sedentary individuals (p<0.05). The average progesterone levels of the players and sedentary women were 3.84 ng/ml and 7.88 ng/ml, respectively. In accordance with the Pearson’s correlation analysis that was applied to determine the relationship between progesterone levels and age, height, and weight of the subjects, a slight positive correlation was observed between the age and progesterone levels of the subjects (p=0.015). Despite significant differences between the groups with respect to progesterone levels, these values in both groups were within normal limits.

Pregnancy in a patient with univentricular circulation: A case report and literature review

Univentricular heart is a complex congenital heart disease. With pregnancy, the complexity of disease increases and it has many risks for fetus and mother, including maternal mortality. Successful pregnancy results are very rare. We report a case of an univentricular pregnancy managed successfully with the help of multidisciplinary management.

The impact of progesterone supplementation on pregnancy rates after intrauterine insemination in patients developing a single follicle

Abstract The objective was to determine whether progesterone support affects pregnancy rates in patients who develop a single follicle. This was a non-randomized prospective controlled study performed on 591 intrauterine insemination (IUI) cycles that developed a single follicle; 337 women received 100 mg oral progesterone daily. The pregnancy rate was 24.3%, or 82 out of 337, in the group receiving progesterone support compared with 14.96%, or 254 out of 591, in the group with no progesterone support. IUI luteal phase supplementation with oral progesterone may improve clinical pregnancy rates when begun the day after insemination.

46, XY, t(5;8) (q33,2;q22,2) KARYOTİPLİ BİR FETÜS

OZET Bu calismada; ileri anne yasi nedeniyle prenatal tani amaciyla laboratuvara refere edilen bir kadin olgunun, de novo t(5;8)(q33,2;q22,2) dengeli resiprokal translokasyon tasiyicisi fetusunu tartistik. Olgunun aile oykusunun degerlendirilmesinin ardindan, periferik kan kulturu metodu kullanarak olgu ve aile bireylerinden elde edilen preparatlar GTG bantlama yontemiyle degerlendirildi. Ileri anne yasi nedeniyle prenatal tani amaciyla laboratuvara refere edilen kadin olgunun fetus’unden yapilan sitogenetik analizler sonucunda, fetus’un dengeli resiprokal translokasyon tasiyicisi oldugu goruldu. Fetus’un annesi, babasi ve iki kardesinde yapilan analizlerde; aile bireylerinin normal karyotiplere sahip olduklari goruldu. Saptanan dengeli resiprokal translokasyonun anne yasi ile iliskili olarak DNA tamir mekanizmalarinda olusan hata nedeniyle ortaya ciktigi kanaatine varildi. Bu calismada, fetus’un genetik ozelliklerini literatur isiginda tartistik. Anahtar kelimeler: Anne yasi, prenatal tani, kromozomal translokasyon

Antenatal Diagnosis of Par tial Trisomy 8 and Partial Monosomy 1: A Case Report

Abstract A case of prenatally diagnosed partial trisomy 8 and partial monosomy 1 is described. The syndrome is associated with skeletal and cardiac anomalies, as well as hepatic calcification, presented with severe central nervous system malformations. Homogenous and complete trisomy 8 is an extremely rare case. In this case routine karyotyping with (Giemsa-Trypsin) GTG banding for diagnosis was carried out from amniotic fluid at 16 weeks of gestation. Peripheral blood of both parents were karyotyped. Only the father was found to have an abnormal karyotype; resiprocal translocation between chromosome 1p and 8p [46,XY, t(1;8)(p36.1;p21.3)]. The fetal karyotype was, [46,XY, der(1)del(1)(p36.1 → pter) dup(8)(p21.3 → pter) t(1;8)(p36.1;p21.3)]. This reported case of partial trisomy for this region of chromosome 8 is the first prospectively diagnosed antenatal case in which ultrasound anomalies are noted.