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Featured researches published by Db Saris.


American Journal of Sports Medicine | 2009

Physical Activity Levels After Characterized Chondrocyte Implantation Versus Microfracture in the Knee and the Relationship to Objective Functional Outcome With 2-year Follow-up

Dieter Van Assche; Danny Van Caspel; Johan Vanlauwe; Johan Bellemans; Db Saris; Frank P. Luyten; Filip Staes

Background Characterized chondrocyte implantation results in superior structural repair compared with microfracture, but may be associated with a slower recovery of physical activity levels due to the arthrotomy. Hypotheses Our hypotheses were that (1) microfracture results in increased activity levels over 2 years after surgery compared with characterized chondrocyte implantation, (2) patients with high preinjury activity levels have a better functional outcome, and (3) high levels of low-load activities after surgery improve functional outcome. Study Design Cohort study; Level of evidence, 2. Methods Sixty-seven patients with local cartilage defects (mean size, 2.4 cm2; standard deviation, 1.5 cm2) of the femoral condyle underwent characterized chondrocyte implantation (n = 33) or microfracture (n = 34), followed by an identical rehabilitation protocol. Activity levels (assessed using the Activity Rating Scale) and functional outcome were determined at baseline, and 1 and 2 years after surgery. Functional outcome was based on the pooled symmetry index (derived from isokinetic knee extension strength and 3 one-legged hop tests). Patients’ participation in low-load activities during the first 3 months after surgery was assessed using rehabilitation data. Mixed linear model analyses and Wilcoxon rank sum tests were used. Results Activity levels in patients treated with characterized chondrocyte implantation and microfracture were comparable at 1 and 2 years after surgery. Preinjury activity levels showed no relationship to functional outcome. Lack of postoperative low-load activities resulted in a significantly worse functional outcome (mean pooled symmetry index 78.2%) compared with high levels of postoperative surgery low-load activities (mean pooled symmetry index 92.4%). Conclusion Despite differences between the characterized chondrocyte implantation and microfracture procedures, patients’ activity levels were comparable at 2 years after surgery. Lack of low-load activities after surgery adversely affected functional outcome.


Osteoarthritis and Cartilage | 2007

29.4 Comparison of structural repair following characterized chondrocyte implantation or microfracture for the treatment of symptomatic cartilage defects of the knee

Db Saris; Johan Vanlauwe; J. Victor; Johan Bellemans; Frank P. Luyten

Purpose: This study compared the efficacy and safety of Characterized Chondrocyte Implantation (CCI) to microfracture in the repair of symptomatic cartilage defects of the femoral condyle. Methods: CCI (n=51) was compared to microfracture (n=61) in patients with grade III–IV symptomatic cartilage defects of the femoral condyles in a prospective, multicenter, randomized, controlled trial. Structural repair was assessed at 1 year by histopathologists blinded to the treatment using computerized histomorphometry and an overall histology assessment. Clinical outcome was measured using the Knee Injury and Osteoarthritis Outcome Score (KOOS). Safety was recorded throughout the study. Results: CCI resulted in better structural repair than microfracture at 1 year post-treatment, as assessed by histomorphometry (p=0.003) and overall histology (p=0.012). Structural repair parameters relating to chondrocyte phenotype and tissue structure were also superior with CCI. Noninferiority of CCI was demonstrated for clinical outcome at 12–18 months, and both treatments were generally well tolerated. Conclusion: At 1 year post-treatment, CCI resulted in superior tissue repair compared to microfracture. Short-term clinical outcome after 12–18 months was similar for both treatments, as was the safety profile. The superior structural repair achieved with CCI may lead to improved long-term clinical benefits.


Osteoarthritis and Cartilage | 2007

P48 Characterized chondrocyte implantation has a similar safety profile to microfracture forthe treatment of symptomatic cartilage defects of the knee

Johan Vanlauwe; J. Victor; Db Saris; Johan Bellemans; Frank P. Luyten

Purpose: As a one-step surgical procedure, microfracture is frequently considered to be technically easier and associated with less postoperative morbidity than autologous chondrocyte implantation (ACI), which involves both arthrotomy and arthroscopy and therefore safety was assessed in patients with symptomatic cartilage lesions of the knee treated with characterized chondrocyte implantation (CCI) or microfracture. Methods: CCI (n=57) was compared to microfracture (n=61) in patients with grade III–IV symptomatic cartilage defects of the femoral condyles in a Phase III, prospective, multi-center, randomized, controlled trial. Safety assessments included adverse events (AEs), physical examination, vital signs, hematology and clinical chemistry. Results: At 18 months post-surgery, similar proportions of patients experienced AEs in the CCI (88%) and microfracture (82%) groups; 67% and 59%, respectively, experienced AEs considered treatment related. The AE profile was generally similar between groups, with no significant difference for hypertrophy, although significantly more CCI-treated patients had joint swelling (19% versus 4.9%; p=0.022) and treatment-related joint crepitation (12% versus 1.6%; p=0.028). Although the proportion of patients with severe AEs was similar for CCI (12%) and microfracture (13%), slightly more microfracture-treated patients experienced serious (life-threatening or requiring hospitalization) AEs (13% versus 8.8%). No patients discontinued due to AEs or died during the study. Conclusion: Contrary to general opinion, the two-step CCI procedure, involving arthroscopy followed by arthrotomy, has a similar safety profile to that of microfracture, a one-step arthroscopic procedure, for treating cartilage lesions of the knee.


abstract book ICRS 2009 | 2009

Sports participation and patient perspective after cartilage repair of the knee: a comparison between characterized chondrocyte implantation and microfracture; results after three years

Dieter Van Assche; Melanie Inklaar; Db Saris; Johan Vanlauwe; Filip Staes; Frank P. Luyten


JOURNAL OF BONE AND JOINT SURGERY. BRITISH VOLUME. ORTHOPAEDIC PROCEEDINGS | 2011

IMPLANTATION OF CHONDROCELECT® LEADS TO SIGNIFICANT CLINICAL BENEFIT AT 36 MONTHS POST-SURGERY AS COMPARED TO MICROFRACTURE

Karl Almqvist; Db Saris; Johan Vanlauwe; Jan Victor; Frank P. Luyten


Knee Surgery, Sports Traumatology, Arthroscopy | 2010

Repair of symptomatic cartilage defects of the femoral condyle and trochlea with ChondroCelect under compassionate use

Karl Almqvist; Db Saris; Johan Vanlauwe; Peter Verdonk; Jan Victor; J Bellemans; René Verdonk


ICRS Abstract Book 2010 | 2010

High patient compliance to an identical rehabilitation guideline after characterized chondrocyte implantation or microfracture is related to improved patient functional outcome at 2 years

Dieter Van Assche; Danny Van Caspel; Filip Staes; Db Saris; Johan Bellemans; Johan Vanlauwe; Frank P. Luyten


Proceedings of the AAOS 2009 Annual Meeting | 2009

Characterized chondrocyte implantation randomized versus microfracturing

Db Saris; Johan Vanlauwe; Jan Victor; Karl Almqvist; J Bellemans; René Verdonk; Frank P. Luyten


Abstract book 8th World Congress of the International Cartilage Repair Society | 2009

Comparison of characterized chondrocyte implantation versus microfracture in the treatment of symptomatic full-thickness defects of the knee: results after three years

Db Saris; Johan Vanlauwe; Jan Victor; Karl Almqvist; J Bellemans; Peter Verdonk; Frank P. Luyten


83e Réunion Annuelle de la SOFCOT | 2008

Microfractures versus implantation par chondrocytes caractérisées dans le traitement des lésions symptomatiques cartilagineuses

René Verdonk; Db Saris; Johan Van Lauwe; Jan Victor; J Bellemans; Frank P. Luyten

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Frank P. Luyten

Katholieke Universiteit Leuven

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Johan Vanlauwe

Free University of Brussels

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Johan Bellemans

Katholieke Universiteit Leuven

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Filip Staes

Katholieke Universiteit Leuven

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Dieter Van Assche

Katholieke Universiteit Leuven

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Karl Almqvist

Ghent University Hospital

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J Bellemans

University of Pennsylvania

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Jan Victor

University of Pennsylvania

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