de la Chapelle A

2002 William Allan Award Address. Inherited human diseases: victories, challenges, disappointments.

More than 1,000 disease genes have been cloned and their mutations characterized, including those that account for the most common Mendelian disorders. While this represents one glorious consequence of the global genome initiatives, it also is a mere beginning.Received November 5, 2002; accepted for publicationNovember14, 2002; electronically published January 23, 2003.Address for correspondence and reprints: Dr. Albert de la Cha-pelle, Human Cancer Genetics Program, 646 Tzagournis MedicalResearch Facility, 420 West 12th Avenue, Columbus, OH 43210.E-mail: delachapelle-1@medctr.osu.edu* Previously presented at the annual meeting of The AmericanSociety of Human Genetics, in Baltimore, on October 18, 2002.