Debbie Humphries
Yale University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Debbie Humphries.
Clinical Infectious Diseases | 2002
Jeffrey M. Bethony; Jizhang Chen; Shaoxiong Lin; Shu-Hua Xiao; Bin Zhan; Shangwen Li; Xue H; Fuying Xing; Debbie Humphries; Wang Yan; Grace Chen; Virginia Foster; John M. Hawdon; Peter J. Hotez
We examined risk factors associated with Necator americanus infection among persons aged > or =50 years in Hainan Province, Peoples Republic of China. Age and sex made the most important contributions to the variation in infection intensity (28%-30%), with age alone responsible for 27% of this variation. When stratified by 20-year age intervals, the influence of shared residence was 23% for persons aged > or =50 years and 27% for those aged <20 years, who had the highest and lowest levels of infection intensity, respectively. This points to shared residence as a means of capturing the complex relationship between aging and shared socioeconomic, environmental, and behavioral factors that influence transmission of Necator infection. None of the other 26 personal or 32 household risk factors were found to be significant. The importance of aging in Necator infection reveals an emerging public health problem among the elderly population of developing countries.
American Journal of Tropical Medicine and Hygiene | 2011
Debbie Humphries; Emily Mosites; Joseph Otchere; Welbeck Amoani Twum; Lauren Woo; Hinckley Jones-Sanpei; Lisa M. Harrison; Richard D. Bungiro; Blair Benham-Pyle; Langbong Bimi; Dominic Edoh; Kwabena M. Bosompem; Michael D. Wilson; Michael Cappello
A cross-sectional pilot study of hookworm infection was carried out among 292 subjects from 62 households in Kintampo North, Ghana. The overall prevalence of hookworm infection was 45%, peaking in those 11-20 years old (58.5%). In children, risk factors for hookworm infection included coinfection with malaria and increased serum immunoglobulin G reactivity to hookworm secretory antigens. Risk factors for infection in adults included poor nutritional status, not using a latrine, not wearing shoes, and occupation (farming). Although albendazole therapy was associated with an overall egg reduction rate of 82%, 37 subjects (39%) remained infected. Among those who failed therapy, treatment was not associated with a significant reduction in egg excretion, and nearly one-third had higher counts on repeat examination. These data confirm a high prevalence of low-intensity hookworm infection in central Ghana and its association with poor nutritional status. The high rate of albendazole failure raises concern about emerging resistance.
Transactions of The Royal Society of Tropical Medicine and Hygiene | 1997
Debbie Humphries; L.S. Stephenson; Edward J. Pearce; H.T. Dan; L.T. Khanh
To investigate different factors associated with hookworm infections we conducted 2 studies in a commune in northern Viet Nam. The first was part of a larger study on anaemia and covered 213 women (15-49 years of age) and their 92 children (6 months to 5 years of age) in one commune; 90% of the families reported using human faeces for fertilizer. Women who reported using fresh human faeces as fertilizer had significantly higher hookworm egg counts than women who either used treated human faeces or who did not use human faeces as fertilizer. The second study examined how human faeces were used for fertilizer in 30 selected families. Women participated in preparation and application of human faeces to crops in 81% of the families using human faeces for fertilizer. Two methods of preparing the faeces were described: 48% of the families mixed the faeces with ash before applying them to the field; 18% mixed the faeces with water; 33% used both methods.
Journal of Nutrition Education and Behavior | 2002
Debra A. Krummel; Debbie Humphries; Irene Tessaro
OBJECTIVE To determine rural womens perceptions about cardiovascular disease (CVD) prevention and behavior change for cardiovascular health. DESIGN A trained moderator and nutritionist (observer) led the groups. The discussion guide was developed from the Health Belief Model and Social Cognitive Theory. The data were analyzed inductively looking at patterns and themes that emerged from the data and deductively looking at relationships from the theoretical models. SUBJECTS Thirty-four white women participated in six groups: three younger (20-40 years; n = 18) and three older (40-55 years; n = 16) groups. Women with no more than 13 years of education were recruited by social service providers, Extension agents, and church groups. RESULTS Rural women were unaware of their personal CVD risks. Common themes included the overriding influence of family preferences and cultural food patterns on womens food choices and the lack of support for adoption of a heart-healthy diet. Self-efficacy for dietary change spanned the continuum from no confidence (younger women) to complete empowerment (older women). CONCLUSIONS Efforts need to be directed toward providing education and skill building for CVD prevention based on a better understanding of womens cultural beliefs and life situations. All women believed that dietary choices were important for cardiovascular health; however, they lacked the skills for food selection and preparation. Family preference and support are key to the adoption and maintenance of a heart-healthy eating plan. For interventions, women preferred active learning (hands-on experiences) coupled with group classes for learning and support. Rural women lacked these resources or access to a nutritionist.
Current Opinion in Infectious Diseases | 2012
Debbie Humphries; Sara Nguyen; Daniel A. Boakye; Michael D. Wilson; Michael Cappello
Purpose of review Intestinal helminth infections continue to cause significant morbidity in resource-limited settings. Recent efforts at global control have centered on mass drug administration (MDA) of praziquantel and benzimidazole anthelminthics to reduce the prevalence and intensity of schistosomiasis and soil-transmitted nematode infections, respectively. This review summarizes progress and potential challenges associated with MDA. Recent findings Data from studies conducted in endemic areas show that chemotherapeutic interventions can reduce prevalence and intensity of infection with intestinal helminths, and have the potential to reduce transmission within populations. However, consistent benefits in high-risk groups, including children and pregnant women, have not been established. The long-term benefits of MDA remain to be determined, and the potential for emerging resistance to impact effectiveness have not yet been defined. Conclusions Whereas studies evaluating MDA have shown benefit in certain populations, intensive monitoring and evaluation, as well as a commitment of resources for new drug development, are essential for long-term control or elimination of intestinal helminth infections.
Aging & Mental Health | 2015
Xindi Fang; Wilson Vincent; Sarah K. Calabrese; Timothy G. Heckman; Kathleen J. Sikkema; Debbie Humphries; Nathan B. Hansen
Objectives: This study tested the mediating effect of resilience on the relationship between life stress and health-related quality of life (HRQoL) in older people, 50 years of age and older, living with HIV/AIDS (OPLWHA). Method: Data from 299 OPLWHA were analyzed using structural equation modeling (SEM) to define a novel resilience construct (represented by coping self-efficacy, active coping, hope/optimism, and social support) and to assess mediating effects of resilience on the association between life stress and HRQoL (physical, emotional, and functional/global well-being). Results: SEM analyses showed satisfactory model fit for both resilience and mediational models, with resilience mediating the associations between life stress and physical, emotional, and functional/global well-being. Conclusion: Resilience may reduce the negative influence of life stress on physical, emotional, and functional/global well-being in OPLWHA. Interventions that build personal capacity, coping skills, and social support may contribute to better management of HIV/AIDS and increase HRQoL.
American Journal of Tropical Medicine and Hygiene | 2013
Debbie Humphries; Benjamin T. Simms; Dylan Davey; Joseph Otchere; Josephine Quagraine; Shawn Terryah; Samuel Newton; Elyssa Berg; Lisa M. Harrison; Daniel A. Boakye; Michael D. Wilson; Michael Cappello
Children (n = 812) 6-11 years of age attending 16 schools in the Kintampo North Municipality of Ghana were screened for participation in a study on hookworm infection, nutrition, and response to albendazole. The prevalence of Necator americanus hookworm infection (n = 286) was 39.1%, and significant predictors of infection included age, malaria parasitemia, lack of health care, school area, levels of antibodies against hookworm, and low consumption of animal foods. The cure rate after a single dose (400 mg) albendazole was 43%, and the mean fecal egg count reduction rate was 87.3%. Data for an in vitro egg hatch assay showed a trend toward reduced albendazole susceptibility in post-treatment hookworm isolates (P = 0.06). In summary, hookworm infection is prevalent among school age children in the Kintampo North Municipality and animal food intake inversely correlates with infection status. Modest cure rates and fecal egg count reduction rates reinforce the need for further investigation of potential benzimidazole resistance in Ghana.
Health Promotion International | 2008
Kari A. Hartwig; Debbie Humphries; Zethu Matebeni
In this paper, we present the evaluation results of an AIDS non-governmental organization (NGO) capacity building 20-month pilot initiative in five countries in southern Africa called the NGO Institute. A five-person international team conducted a 2 week evaluation of the pilot in 2004 to assess the strength of the model, designed and funded by Bristol-Myers Squibb Foundation. The NGO Institute functioned through a separate consortium in each country. Results of the pilot indicate variations in adaptation and implementation of the model in each of the five countries. Each consortium took considerable time to develop its own governance and management systems. There were examples of strengthened NGO capacity in each country although it was too soon to establish overall impact. The strengths and weaknesses of this NGO capacity building model are presented along with the implications for other funding agencies and NGOs.
Appetite | 2013
Lindsey Smith; Katharine Conroy; Hongmei Wen; Li Rui; Debbie Humphries
Age and portion size have been found to influence food intake in American children but have not been examined in an international context. This study evaluated the association between age and the effects of portion size on the food intake of kindergarteners in Kunming, China. Using a within-subjects crossover design in a classroom setting, 173 children in two age groups, mean age 4.2 years and 6.1 years, were served a predefined reference, small (-30%) and large (+30%) portion of rice, vegetables, and a protein source during lunchtime over three consecutive days. Each portion was weighed before and after the meal to determine amount of food consumed. Linear mixed modeling, controlling for repeated measures and clustering by classroom, was used to compare food intake under small and large portion size conditions to the reference portion. Children ate significantly less food when served small portions. When served a large portion, 6-year-old children increased food intake while 4-year-old children decreased food intake in comparison to the reference portion. Findings indicate that portion size affects food intake in Chinese children 4-6-years old. Older children show larger increases in food intake with increased portion size than do younger children.
International Journal of Health Planning and Management | 2011
Debbie Humphries; Ligia Gomez; Kari A. Hartwig
Despite an increase in organizational capacity building efforts by external organizations in low and middle income countries, the documentation of these efforts and their effects on health programs and systems remains limited. This paper reviews key frameworks for considering sustainability of capacity building and applies these frameworks to an evaluation of the sustainability of an AIDS non-governmental organization (NGO) capacity building initiative. From 2004-2007 Bristol-Myers Squibb Foundations Secure the Future(TM) initiative in southern Africa funded a five country program, the NGO Training Institute (NGOTI), to build capacity of NGOs working to address HIV/AIDS. Lessons learned from this project include issues of ownership, the importance of integrating planning for sustainability within capacity-building projects, and the value of identifying primary capacity-building objectives in order to select sustainability strategies that are focused on maintaining program benefits. Sustainability for capacity building projects can be developed by discussing key issues early in the planning process with all primary stakeholders.