Débora Rosana Ribeiro Penido Araujo

Preparation and antitubercular activity of lipophilic diamines and amino alcohols.

A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 microg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 microg/mL.

Synthesis and antitubercular evaluation of new fluoroquinolone derivatives coupled with carbohydrates

We describe in this work the synthesis of nine new fluoroquinolone derivatives based on modifications at the C-7 position of the known fluoroquinolones cipro-, gati-, and moxifloxacin, as well as their antitubercular evaluation. The synthesis of these new analogues was improved using microwave irradiation, providing several advantages such as better yields and shorter reaction times, in comparison with classical reaction conditions. Derivatives 4, 5, and 7 exhibited promising antitubercular activities.

Assessment of Leishmanicidal and Trypanocidal activities of Aliphatic Diamine derivatives

Leishmanicidal and trypanocidal activity of seventeen lipophilic diamines was evaluated in vitro against Leishmania braziliensis, L. chagasi, and Trypanosoma cruzi. Twelve compounds presented anti‐Leishmania and six showed anti‐T. cruzi amastigote activity. Compound 14 (N‐tetradecyl‐1,4‐butanediamine) was the most active against both L. braziliensis (IC50 = 2.6 μm) and L. chagasi (IC50 = 3.0 μm) which showed a selectivity index (SI) >100. N‐decyl‐1,6‐hexanediamine (compound 9) presented an IC50 = 1.6 μm and SI >187 and was over six times more potent than the reference drug benznidazole against T. cruzi. Treatment of infected or uninfected macrophages with compounds 9 and 14 did not induce significant TNFα and NO production. Four compounds (15, 16, 22, and 23) inhibited 78.9%, 77.7%, 83.7%, and 70.1% of rTRLb activity, respectively, and compound 23 inhibited 73.3% of rTRTc activity at 100 μm. A concentration‐dependent effect on mitochondrial membrane depolarization was observed in T. cruzi epimastigotes treated with compound 9, suggesting this mechanism may be involved in the trypanocidal effect. On the contrary, in L. braziliensis promastigotes treated with compound 14, no mitochondrial depolarization was observed. Our results demonstrate that N‐decyl‐1,6‐hexanediamine and N‐tetradecyl‐1,4‐butanediamine are promising molecules for the development of novel leading compounds against T. cruzi and Leishmania spp., particularly given a possible alternative mechanism of action.

Evaluation of the impact of different neural network structure and data input on fault detection

This paper presents a methodology for detecting single-phase fault in medium voltage distribution systems using neural network. The impact of diverse types of neural network topologies and different inputs in the performance of the fault detection is assessed. The entries of the neural network are the electrical parameters of voltage and current, which could be phasor and / or non-phasor measurements. The proposed methodology aims to identify single-phase faults with an arc resistance ranging from 0 to 20 ohms, considering the variation of the system load.

Simulations and analysis of distribution systems with aspects of smart grids using MICQ, RTDS and PSCAD

This paper presents a procedure for the analysis of distribution systems including aspects of smart grids such as the inclusion of distributed generators and protection devices. The procedure uses MICQ to obtain detailed and accurate results. The results are compared with RTDS and PSCAD simulations. Some studies are performed to analyze distribution system performance in real time and protection devices.

Uso inadequado de áreas de preservação permanente segundo a legislação ambiental

The present work sought to analyze the inadequate use of permanent preservation areas (PPA)according to the environmental legislation of the Stream Três Barras watershed Botucatu (SP) through the use of Geographical Information System SIG Idrisi Andes 15.0 and of digital satellite image. The area with 1639,19ha, locates among the plane coordinates: 763968 to 768484 of longitudes W and 7471516 to 7476168 of latitude S. The map of soil use of 2006 was obtained starting from the classification supervised in digital satellite image of 23/10/2006. In the digital identification of the objectives the interpretation keys were used for images and the certain areas through the software SIG Idrisi. The area of PPA discriminated along the drainage net was of 137,93ha (8,41%). However, 40,68ha of the area of PPA are busy with pasture (19,08%), irrigated rice (8,61%, annual culture (0,91% and reforestation (0,89%) in an inadequate way (I conflict). Therefore, 70,51% of area of PPA have been used partially appropriately.