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Dive into the research topics where Deboye O. Kolawole is active.

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Featured researches published by Deboye O. Kolawole.


PLOS ONE | 2013

Characterization of Colonizing Staphylococcus aureus Isolated from Surgical Wards' Patients in a Nigerian University Hospital

Deboye O. Kolawole; Adeniran Adeyanju; Frieder Schaumburg; Al Akinyoola; Oladejo O. Lawal; Yemisi Bola Amusa; Robin Köck; Karsten Becker

In contrast to developed countries, only limited data on the prevalence, resistance and clonal structure of Staphylococcus aureus are available for African countries. Since S. aureus carriage is a risk factor for postoperative wound infection, patients who had been hospitalized in surgical wards in a Nigerian University Teaching Hospital were screened for S. aureus carriage. All S. aureus isolates were genotyped (spa, agr) and assigned to multilocus sequence types (MLST). Species affiliation, methicillin-resistance, and the possession of pyrogenic toxin superantigens (PTSAg), exfoliative toxins (ETs) and Panton-Valentine Leukocidin (PVL) were analyzed. Of 192 patients screened, the S. aureus carrier rate was 31.8 % (n = 61). Of these isolates, 7 (11.5%) were methicillin-resistant (MRSA). The isolates comprised 24 spa types. The most frequent spa types were t064, t084, t311, and t1931, while the most prevalent MLST clonal complexes were CC5 and CC15. The most frequent PTSAg genes detected were seg/sei (41.0%) followed by seb (29.5%), sea (19.7%), seh (14.7%) and sec (11.5). The difference between the possession of classical and newly described PTSAg genes was not significant (63.9% versus 59.0% respectively; P = 0.602). PVL encoding genes were found in 39.3% isolates. All MRSA isolates were PVL negative, SCCmec types I and VI in MLST CC 5 and CC 30, respectively. Typing of the accessory gene regulator (agr) showed the following distribution: agr group 1 (n = 20), group II (n = 17), group III (n = 14) and group IV (n = 10). Compared to European data, enterotoxin gene seb and PVL-encoding genes were more prevalent in Nigerian methicillin-susceptible S. aureus isolates, which may therefore act as potential reservoir for PVL and PTSAg genes.


International Journal of Antimicrobial Agents | 2012

Clonal expansion accounts for an excess of antimicrobial resistance in Staphylococcus aureus colonising HIV-positive individuals in Lagos, Nigeria

Adesola O. Olalekan; Frieder Schaumburg; Dennis Nurjadi; Adobi E. Dike; Olusola Ojurongbe; Deboye O. Kolawole; Jürgen Kun; Philipp Zanger

Nasal colonisation with Staphylococcus aureus is a risk factor for invasive infection in human immunodeficiency virus (HIV)-positive individuals. This study aimed to characterise colonising S. aureus from regions with a high HIV prevalence. Single nasal swabs were taken from a total of 374 HIV-positive and 370 healthy individuals. Overall, 202 S. aureus carriers were detected. Compared with healthy individuals, HIV-positive subjects were more likely to be S. aureus nasal carriers (33% vs. 21%; P=0.0001). Isolates from HIV-positive individuals were more often resistant to meticillin (16% vs. 8%; P=0.13), chloramphenicol (47% vs. 16%; P<0.0001), sulfamethoxazole/trimethoprim (SXT) (90% vs. 55%; P<0.0001) and ciprofloxacin (18% vs. 0%; P<0.0001). Strains belonging to the spa clonal complexes 3772/ST25 and 064/ST8 were significantly more often isolated from HIV-positive individuals and exhibited greater resistance to ciprofloxacin, SXT and chloramphenicol (spa-CC 3772) or to meticillin (spa-CC 064), respectively. Panton-Valentine leukocidin gene content was high overall and was equally distributed between isolates from HIV-positive and healthy individuals (33% vs. 30%). Genotypic characteristics of colonising isolates were similar to those reported to cause invasive infection in Nigeria. The HIV pandemic contributes to the evolution of antimicrobial resistance in S. aureus. Measures to contain antimicrobial resistance of S. aureus in Nigeria must target risk groups such as HIV-positive individuals.


Journal of Hygiene | 1984

Mechanisms of resistance of staphylococci grown in plasma to polymorph bactericidins.

Deboye O. Kolawole

The mechanisms whereby staphylococcal strains grown in plasma assume increased resistance to polymorph bactericidins were investigated. Observations reported here showed that cultural conditions could determine the path of conversion to resistance. Staphylococcal strains and mutants lacking either free coagulase or clumping factor or both all showed enhanced resistance after 10 h incubation in plasma proteins, thus giving no clear indication that these factors were involved in the interactions. In fact, prolonged incubation in bovine serum albumin (22 h) and ordinary broth medium (24 h) also resulted in increased resistance. A distinction between staphylococcal factors interacting specifically with plasma proteins and such non-specific conversions was obtained in two different ways. Stripping of a hypothetical surface protein by treatment with trypsin or 2 M potassium bromide rendered plasma- but not 24 h-broth organisms susceptible, indicating protein coating of plasma-grown organisms. Also free coagulase-positive strains and mutants incubated in plasma for 30 min were converted while those lacking both or possessing clumping factor alone were not. It therefore appears that one of the mechanisms of acquiring resistance involves a rapid interaction between staphylococcal-free coagulase and fibrinogen, resulting in the deposition of fibrin or fibrin derivatives on the bacterial surface.


Journal of Medical Microbiology | 2006

Identification and molecular characterization of mannitol salt positive, coagulase-negative staphylococci from nasal samples of medical personnel and students.

Adebayo Shittu; Johnson Lin; Donald Morrison; Deboye O. Kolawole


Fems Microbiology Letters | 1984

Resistance mechanisms of mucoid-grown Staphylococcus aureus to the antibacterial action of some disinfectants and antiseptics

Deboye O. Kolawole


Journal of Infection | 2003

Isolation and Molecular Confirmation of a Multiresistant Catalase-negative Staphylococcus aureus in Nigeria

A.O Shittu; Johnson Lin; Donald Morrison; Deboye O. Kolawole


Acta Tropica | 2000

Disinfectants/antiseptics in the management of guinea worm ulcers in the rural areas.

Titus Ogunniyi; Peter O Oni; Adewole Juba; S. O. Asaolu; Deboye O. Kolawole


African Journal of Infectious Diseases | 2013

Antibiotic resistance and virulence properties in Escherichia coli strains from cases of urinary tract infections.

Felix Olorunmola; Deboye O. Kolawole; Adebayo Lamikanra


Journal of Hygiene | 1983

Evaluation and use of the drug inhibition method of measuring intracellular killing in differentiating between staphylococci grown in vivo and in vitro.

Deboye O. Kolawole


Tropical Gastroenterology | 2013

Serogroup distribution of Shigella in Ile-Ife, southwest Nigeria

Abdulrasheed Abdu; Aaron O. Aboderin; Jerome B Elusiyan; Deboye O. Kolawole; Adebayo Lamikanra

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Johnson Lin

University of Durban-Westville

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Adebayo Shittu

Obafemi Awolowo University

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Adebayo Lamikanra

Obafemi Awolowo University

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A.O Shittu

University of Zululand

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Aaron O. Aboderin

Obafemi Awolowo University

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Adebayo Shittu

Obafemi Awolowo University

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Adeniran Adeyanju

Obafemi Awolowo University

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Adesola O. Olalekan

Ladoke Akintola University of Technology

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