Dee W. Brooks

Synthetic studies of polyene macrolides, synthesis of a C29–37 fragment for amphotericin B and nystatin

Abstract An enantioselective synthesis of a C29–37 fragment common to both amphotericin B 1 and nystatin 2 is described from ethyl 3(S)-hydroxybutanote.

A convergent synthetic strategy for the polyene macrolide pimaricin

Abstract The synthesis of two chiral fragments representing Cl-11 and C12-25 of the polyene macrolide pimaricin from dimethyl 3-hydroxyglutarate is described.

Remote substituent effects in microbial reductions of 3-ketoglutarate and 3-ketoadipate esters

Abstract The enantioselectivity of yeast mediated reductions of prochiral 3-ketoglutarate and 3-ketoadipate esters to the corresponding 3-hydroxyesters can be influenced by simple differences in the ester groups.

Synthetic studies of trichothecenes, an enantioselective synthesis of a C-ring precursor of anguidine

Abstract An enantioselective synthesis of a cyclopentanoid C-ring precursor 1 9 of anguidine 3 , a representative trichothecene with antitumor activity, from 2-allyl-2-methylcyclopentane-1,3-dione is described.

Chiral cyclohexanoid synthetic precursors via asymmetricmicrobial reduction of prochiral cyclohexanediones

Abstract Microbial reduction of various 2,2-disubstituted-1,3-cyclohexanediones with bakers yeast provides efficient access to chiral cyclohexanoid synthetic precursors.