nan Deepika

Formulation and Evaluation of Self-Poring Osmotic Tablet of Diltiazem HCl for the Treatment of Hypertension

With emergence of new technology and concept, self-poring osmotic tablets were developed in order to reduce the complications and problems associated with micro drilling and laser drilling in osmotic tablet. This research describes a very simple and cheap method of developing self-poring osmotic tablet that deliver DiltiazemHCl in a controlled rate for prolonged duration. For this purpose 5 formulations of osmotictablets were prepared through wet granulation technique in which different concentration of sodium lauryl sulphate (SLS) were used as pore forming agent in coating solution. In tablet core also varied concentration of sorbitol as osmogens, guar gum and HPMC were encorporated, which forms gel like matrix through which drug releases at zero order. Through optimization out of 5 formulations, F3 (C2) formulation was selected as best. From result of invitro drug release study it was clear that more concentration of pore former and osmogens releases drug in short time while less concentration takes more time for drug release. Therefore, it is necessary to use SLS, polymer and osmogens in balance concentration for getting optimum control release at zero order upto 24 hrs. Self-poring Osmotic tablets hold promising potential for increasing drug efficacy and reducing dosing frequency with minimal side effects also provides an economic means of developing controlled release dosage forms.

Formulation and evaluation of orodispersible tablet of montelukast sodium

The objective of the current study was to develop and optimize an orodispersible tablet formulation of montelukast sodium which is an effective drug in the treatment of asthma and allergic disorders. Montelukast sodium is the drug used in treatment of ashthmatic and allergicrhinitis; it is selective leukotrienesreceptor antagonist. Orodispersible tablet is rapid dissolving or disintegrates without water within a few minutes in the oral cavity which may produce rapid onset of action due to the action of superdisintegrants. The orodispersible tablet were prepared by direct compression method using superdisintegrant agent such as croscarmilose sodium, crosspovidone and sodium starch glycolate. Six formulations of superdisintegrants having different concentration were prepared. After examine the angle of repose, bulk density, tapped density, Compressibility index and Hausners ratio of powder blend the results were found to be within prescribed limits and indicated good flowing property. The tablets were evaluated for hardness, drug content, friability, weight variation, wetting time and in vitro disintegration time and were found to be satisfactory. Among the formulations tablets of batch F3 and F6 containing co-processed disintegrating agents like croscarmilose: sodium starch glycolate (1: 2) and crospovidone: croscarmiloss sodium (1: 2) respectively showed superior organoleptic properties along with excellent in-vitro disintegration time and drug release as compare to other formulations. Hence crospovidone is recommended as suitable disintegrant for the preparation of direct compression mouth dissolving tablets of Montelukast sodium.

Formulation and Evaluation of immediate release tablet of Risperidone

The main objective of the present investigation was to formulate Risperidone immediate release tablet. Risperidone, an antipsychotic drug mainly act as a D2 and 5HT2A receptor antagonist. Superdisintegrants agents like kollidon and citric acid were used and compressed into tablet by direct compression method. Risperidone is mainly used to treat schizophrenia bipolar disorder. The six formulations having different concentration of superdisintegrants were prepared and formulation blend was examined for angle of repose, bulk density tapped density and compressibility. The tablet were evaluated for various parameters like hardness, thickness, friability, weight variation, disintegration time and invitro dissolution time, all the parameter were found within limits.

Formulation and Evaluation of directly compressed Floating Tablets of Candesartan Cilexetil for Gastro Retentive Drug Delivery

The candesartan cilexetil floating matrix drug delivery system was design to prolong the gastric residence time and improve its bioavailability. The candesartan cilexetil floating matrix tablet was prepared by using direct compression technique. Various natural polymer such as xanthan gum, guar gum as well as synthetic polymer such as hydroxypropyl methyl cellulose used in combination along with other standard excipients. Here, sodium bicarbonate acts as gas-generating agent. The granules undergoes through pre and post compression studies. The tablet evaluated by using various evaluating parameter viz, hardness, friability, weight variation, content uniformity, floating capacity and in vitro drug release studies.

Formulation and evaluation of Itraconazole mucoadhesive tablets for sustained release

The aim of this research was to prepare and evaluate sustain release mucoadhesive tablet ofitraconazole, in order to overcome its poor biopharmaceutical property and therapeutical efficacy. Itraconazole have low aqueous solubility and high permeability, hence in order to improve its solubility in both HCl and water it is formulated as solid dispersion by using solvent evaporation method. Solid dispersion was formulated using with itraconazole PEG 6000 in the ratio of 1: 2. Solid dispersion was then formulated in matrix of hydrophilic mucoadhesive polymers Carbopol 934P (CP) and HPMC E5LV into mucoadhesive sustained release tablet. Further, formulation were optimized for various amounts of CP and HPMC. Various amount of HPMC and Carbapol were taken as formulation variables for optimizing response variables i.e. dissolution parameters. Solid dispersion leads to enhancement in solubility of itraconazole in water up to 5.95% and in HCl it was 6.43%. In addition to enhancement of solubility in HCl and water they also lead to the slow release of drug up to 1.44% in 1 hour. Optimum combination of mucoadhesive polymers Carbopol 934P (CP) and HPMC E5LV provided adequate fairly regulated release profile. The experimental and predicted results for optimum formulations were found to be in close agreement. The formulation showed percentage drug release upto 86% for 9hour.

Formulation and evaluation of sustained released buccoadhesive tablets of Itraconazole

The aim of present research was to report the buccoadhesive tablet of itraconazole to provide localized delivery of drug for the treatment of oral thrush and maintain the drug concentration in the mouth for prolonged period of time thereby improving the oral bioavailability of drug. Buccoadhesive tablet is a sustained release of itraconazole for easy permeation across buccal mucosa and provide a local delivery concentration that may or may not be sufficient to maintain MIC to kill the microorganism. Solid dispersion of itraconazole was prepared by solvent evaporation technique using silica gel act as adsorbent and drug was soluble in chloroform to obtain a slurry or uniform mixture. The buccoadhesive tablet was prepared by direct compression method using different polymers such as Carbopol(C934P),HPMC K4M, Eudragit E100. Five formulations of different concentrations were prepared. Itraconazole strength were kept constant at 30mg and target was fixed at 120mg. After examine the moisture content, bulk density, tapped density, Angle of repose of powder blend get the result were found to be prescribed limit and indicated good flow property. Then the tablets were evaluated for hardness, thickness, weight variation, drug content, friability, swelling index, In-vitro drug release.

Formulation and Evaluation of Colon Specific Matrix Tablet of Metronidazole

Targeting of drug to the colon oral route the drug release is controlled by the gastrointestinal pH, transit times and intestinal flora. Metronidazole is only used antibiotics, which can be used, in colonic disease. Matrix formulations containing various proportions of Xanthan gum and HPMC E5LV were prepared by wet granulation technique using 10% starch paste. Six Matrix tablet formulation (1 to 6) of Metronidazole were prepared different mixture of Xanthan gum and HPMC-E5LV. All the formulations were evaluated for in-process quality control tests. The in-vitro drug release study first in 0.1N HCl followed by in pH 7.4 phosphate buffer, the formulation F3 show good drug release in control manner. Hence, synthetic polymer such as HPMCE5LV is most cheap and suitable for colonic drug delivery.

Formulation and evaluation of levocetrizine orodispersible tablet

Orodispersible tablets are those that dissolve or disintegrate quickly in the oral cavity, resulting in solution or suspension. Allergic rhinitis is a high-prevalence chronic respiratory disease with a negative impact on the subjects quality of life, work activities, productivity or school performance as well as on healthcare costs. Because of its benign nature, the importance of this condition is often underestimated. In the present study orodispersible tablet of antihistaminic agent was prepared by direct compression method using crosspovidone, Crosscarmellose as superdisintegrants. The tablets prepared were evaluated for various parameters like various density parameters, thickness, hardness, friability, disintegration time, wetting time and In-vitro dissolution time. All the parameters were found to be within limits. The developed formulation oflevocetirizine batch F6 (crosspovidone) showed good palatability and dispersed within 30 seconds as compare to crosscarmellose sodium.