Defne Kalayci

POSTOPERATIVE TOPICAL MITOMYCIN C IN CONJUNCTIVAL SQUAMOUS CELL NEOPLASIA

PURPOSE To report the efficacy of topical mitomycin C in preventing local recurrences after incomplete surgical excision of conjunctival squamous cell neoplasia. METHODS Four patients presented with unilateral conjunctival tumors. Excisional biopsy results revealed conjunctival intraepithelial neoplasia with an intact basement membrane. Neoplastic cells were present in at least one of the surgical borders of the excised conjunctiva in all four cases. Patients were treated with topical mitomycin C 0.02% three times daily for 2 weeks to prevent recurrences. RESULTS All four patients were free of clinically detectable tumors after a mean follow-up period of 20 months (range, 16-23 months). Side effects included mild discomfort, redness, photophobia, and punctate epithelial keratopathy that subsided on discontinuation of the medication. CONCLUSION Postoperative topical mitomycin C application may be a useful adjunct to prevent recurrences in patients with incompletely excised conjunctival squamous cell neoplasia.

Decompression retinopathy and possible risk factors

Purpose:  To discuss the underlying mechanisms in decompression retinopathy.

Penetration of topical 0.3 % ciprofloxacin into human aqueous humor

BACKGROUND AND OBJECTIVE Investigation of the penetration of topical ciprofloxacin into aqueous humor. PATIENTS AND METHODS Topical 0.3% ciprofloxacin drops were administered to 17 patients with cataracts before lens extraction surgery. The time interval between the first dose and sampling was 3 hours in 9 patients (group A) and 6 hours in 8 (group B). In both groups, aqueous samples were collected 30 minutes after the last ciprofloxacin application. Ciprofloxacin concentration was determined by high-performance liquid chromatography-fluorescence detection. RESULTS Mean aqueous concentration was 0.83+/-0.48 microgram/ml in group A and 2.42+/-1.42 micrograms/ml in group B. CONCLUSION Topical 0.3% ciprofloxacin penetrates into the aqueous in a significant concentration.

Craniosynostosis and ectopia lentis in a propositus whose parents are cousins.

We have observed a 6-year-old propositus with craniosynostosis and ectopia lentis. Synostosis of the right parietal and temporoparietal sutures resulted in craniofacial asymmetry. Ectopia lentis was bilateral. The parents were second cousins, suggesting the possibility of autosomal recessive inheritance. However, consanguinity rates arehigher thannormal inTurkey. The disorder has been reviewed byQuercia andTeebi [2002], who reported two cousins: one with craniosynostosis, ectopia lentis, and peripheral pulmonic synostosis, the other with craniosynostosis, atrial septal defect, and mitral valve prolapse, but no ectopia lentis. Cruysberg et al. [1999] reported affected monozygotic twin sisters. Pesme et al. [1950] and Reichel et al. [1992] each described sporadic cases. To date, inheritance is unclear. Both autosomal dominant and autosomal recessive modes of inheritance should be considered. The affected cousins of Quercia and Teebi [2002] suggest dominant inheritance with incomplete penetrance; etiologic heterogeneity is also possible since cardiac defects were found in both cousins. The disorder needs to be further delineated. The disorder is clearly distinguishable from other known conditions with ectopia lentis: Marfan syndrome, cystathionine synthase deficiency (homocystinuria), and Weill–Marchesani syndrome. Isolated ectopia lentis can also occur. REFERENCES