Demet Astley
Ege University
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Featured researches published by Demet Astley.
Journal of Enzyme Inhibition and Medicinal Chemistry | 2015
Neslihan Korkmaz; Oday A. Obaidi; Murat Senturk; Demet Astley; Deniz Ekinci; Claudiu T. Supuran
Abstract A new series of chiral thiourea derivatives (5a–5c) and thiourea containing benzimidazole moieties (9b–9e) were synthesized from different amino acids (l-valine, l-isoleucine, l-methionine, l-phenylalanine, and d-phenylglycine). The compounds were characterized and tested against the two most studied members of the pH regulatory enzyme family, carbonic anhydrase (CA, EC 4.2.1.1). KI values of the novel compounds were measured in the range of 3.4–73.6 μM for hCA I isozyme and 8.7–1.44.2 μM for hCA II isozyme, respectively. Phenol was also tested as standard in order to understand the structure activity relationship and the clinically used sulfonamide acetazolamide was tested for comparison reasons. All of the compounds exhibited competitive inhibition with 4-nitrophenylacetate as substrate.
Journal of Organometallic Chemistry | 1995
Demet Astley; Stephen T. Astley
Abstract ortho -Substituted aryllithium and aryl Grignard reagents react with (benzene)manganesetricarbonyl cation ( 1 ) to give good yields of the expected ring adducts. The presence of the ortho substituent(s) appears to be necessary for the satisfactory outcome of the reaction with aryllithiums. This reactivity opens up the possibility of preparing novel heterocyclic structures via the initial reaction of 1 with functionalised metallated arenes.
Acta Crystallographica Section C-crystal Structure Communications | 2007
Namık Özdemir; Muharrem Dinçer; Gamze Doğaner; Demet Astley; Stephen T. Astley
The title compound, [Zn(C(15)H(11)N(7)O(4))(H(2)O)(2)](NO(3))(PF(6)).3H(2)O, contains a mononuclear zinc(II) complex. The Zn(2+) centre is seven-coordinated in a slightly distorted pentagonal-bipyramidal geometry, with the two water O atoms located in the apical positions, and the pyridine N atom, the two imine N atoms and two carbonyl O atoms of the uracil groups located in the equatorial plane. The charge is balanced by PF(6)(-) and NO(3)(-) anions.
Tetrahedron Letters | 1997
Stephen T. Astley; Demet Astley
Abstract Cis-4a,10b-dihydrophenanthridine derivatives have been prepared in high yield via nucleophilic addition of a functionalised metalated arene to (benzene)tricarbonylmanganese(1+) hexafluorophosphate(1−) followed by reactivation, and intramolecular nucleophile addition.
Applied Organometallic Chemistry | 2000
Selhan Karagöz; Demet Astley; Stephen T. Astley
The reaction of lithium diarylcuprate(I) reagents with o-bromobenzoyl chloride has been investigated. In general, the reaction proceeds well to give synthetically useful o-bromobenzophenone derivatives as the major product. It is suggested that a minor substituent effect, whereby diarylcuprate reagents containing an ortho or meta substituent react more favourably, may be attributed to small changes in the structure of the organometallic reagent. Copyright
Journal of Enzyme Inhibition and Medicinal Chemistry | 2016
Serdar Durdagi; Neslihan Korkmaz; Semra Isik; Daniela Vullo; Demet Astley; Deniz Ekinci; Ramin Ekhteiari Salmas; Murat Senturk; Claudiu T. Supuran
Abstract A series of hydroxylic compounds (1–10, NK-154 and NK-168) have been assayed for the inhibition of three physiologically relevant carbonic anhydrase isozymes, the cytosolic isozymes I, II and tumor-associated isozyme IX. The investigated compounds showed inhibition constants in the range of 0.068–4003, 0.012–9.9 and 0.025–115 μm at the hCA I, hCA II and hCA IX enzymes, respectively. In order to investigate the binding mechanisms of these inhibitors, in silico studies were also applied. Molecular docking scores of the studied compounds are calculated using scoring algorithms, namely Glide/induced fit docking. The inhibitory potencies of the novel compounds were analyzed at the human isoforms hCA I, hCA II and hCA IX as targets and the KI values were calculated.
Zeitschrift für Naturforschung B | 2013
Gamze Koz; Demet Astley; Stephen T. Astley
A series of stable acyclic aminals derived from L-(+)-aspartic acid were synthesized in excellent yields (up to 96%) and characterized by spectroscopic methods. They were applied as enantioselective catalysts in Henry reactions of nitromethane with various aldehydes in the presence of Cu(II) ions, affording the corresponding adducts in high yields (up to 90%) and enantioselectivities (up to 92% ee). Graphical Abstract Synthesis of Stable Acyclic Aminals Derived from L-(+)-Aspartic Acid and Their Application in Asymmetric Henry Reactions
Turkish Journal of Chemistry | 2011
Gamze Koz; Demet Astley; Stephen T. Astley
Journal of Molecular Structure | 2010
Gamze Koz; Namık Özdemir; Demet Astley; Muharrem Dinçer; Stephen T. Astley
gazi university journal of science | 2011
Gamze Koz; Hale Kaya; Demet Astley; İhsan Yasa; Stephen T. Astley