Demet Erdönmez
Hacettepe University
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Publication
Featured researches published by Demet Erdönmez.
International Journal of Polymeric Materials | 2015
Zakir M. O. Rzayev; Demet Erdönmez; Kübra Erkan; Murat Şimşek; Ulviye Bunyatova
Nanofibrous films and coatings were fabricated by electrospinning and centrifugal spinning of aqueous solutions of poly(vinyl alcohol-co-vinyl acetate)/octadecyl amine-montmorillonite layered silicate nanocomposites with/without in situ generated silver nanoparticles (AgNPs). Characterization of nanofibers were realized by FTIR, XRD, SEM, and thermal analysis methods. It was found that AgNPs significantly accelerated phase separation process providing fine distribution of nanofibers. Antifungal and antimicrobial activities of nanocomposites investigated by using Candida Spp fungals, G-positive and G-negative microorganisms strongly depended on chemical/physical structural factors, and loading silver species. Observed effective properties of nanomaterials can be employed for many applications (e.g., air filtration, food packaging, biomedical). GRAPHICAL ABSTRACT
Archives of Microbiology | 2017
Demet Erdönmez; Abbas Yousefi Rad; Nilüfer Aksöz
Acinetobacter species remain alive in hospitals on various surfaces, both dry and moist, forming an important source of hospital infections. These bacteria are naturally resistant to many antibiotic classes. Although the role of the quorum sensing system in regulating the virulence factors of Acinetobacter species has not been fully elucidated, it has been reported that they play a role in bacterial biofilm formation. The biofilm formation helps them to survive under unfavorable growth conditions and antimicrobial treatments. It is based on the accumulation of bacterial communication signal molecules in the area. In this study, we compared the bacterial signal molecules of 50 nosocomial Acinetobacter baumannii strain and 20 A. baumannii strain isolated from soil. The signal molecules were detected by the biosensor bacteria (Chromobacterium violaceum 026, Agrobacterium tumefaciens A136, and Agrobacterium tumefaciens NTL1) and their separation was determined by thin-layer chromatography. As a result, it has been found that soil-borne isolates can produce 3-oxo-C8-AHL and C8-AHL, whereas nosocomial-derived isolates can produce long-chain signals such as C10-AHL, C12-AHL, C14-AHL and C16-AHL. According to these results, it is possible to understand that these signal molecules are found in the infection caused by A. baumannii. The inhibition of this signaling molecules in a communication could use to prevent multiple antibiotic resistance of these bacteria.
Brazilian Archives of Biology and Technology | 2018
Demet Erdönmez; Abbas Yousefi Rad; Nilüfer Aksöz
Quorum sensing system plays an active role in the regulation of pathogenicity of many microorganisms. Inhibition of pathogenicity or virulence factors will increase the success of treatment by preventing the development of antibiotic resistance. In this study, anti-quorum sensing activities of quercetin and resveratrol compounds, which have antioxidant property without damaging to host, have been determined via using biosensor bacteria: Chromobacterium violaceum ATCC 12472 and Chromobacterium violaceum CV026. As quorum sensing inhibitors, quercetin and resveratrols cutting off the bacterial communication will prevent the treatment failures caused by the development of bacterial resistance. The development of layered drugs with antioxidant compounds such as quercetin and resveratrol will pave the way for new horizons for new therapeutic strategies.
Applied Surface Science | 2014
Demet Erdönmez; S. Mosayyebi; Kübra Erkan; Kouroush Salimi; Nilüfer Nagizade; Necdet Sağlam; Zakir M. O. Rzayev
Trakya University Journal of Natural Sciences | 2018
Demet Erdönmez; Nihal Kenar; Kübra Erkan Türkmen
Hacettepe Journal of Biology and Chemistry | 2018
Demet Erdönmez; Kübra Erkan Türkmen; Nilüfer Aksöz
Journal of Biotechnology | 2016
Kübra Erkan Türkmen; Demet Erdönmez; Nilüfer Aksöz
Journal of Biotechnology | 2014
Demet Erdönmez; Kübra Erkan; Solmaz Mosayyebi; Necdet Sağlam; Ali Osman Belduz
Journal of Biotechnology | 2014
Kübra Erkan; Demet Erdönmez; Minoo Poorhasan Schamchi; Necdet Sağlam; Hikmet Türk Katırcıoğlu; Nilüfer Aksöz
Current Opinion in Biotechnology | 2013
Kübra Erkan; Demet Erdönmez; Zakir M. O. Rzayev; Necdet Sağlam; Kouroush Salimi; Nilüfer Nagizade