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Dive into the research topics where Demet Sengul is active.

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Featured researches published by Demet Sengul.


Asian Pacific Journal of Cancer Prevention | 2014

Population-Based Cervical Screening Outcomes in Turkey over a Period of Approximately Nine and a Half Years with Emphasis on Results for Women Aged 30-34

Demet Sengul; Serdar Altinay; Hulya Oksuz; Hanife Demirturk; Engin Korkmazer

PURPOSE To appraise the frequency of cervical cytological abnormalities in a population at normal risk via analysing the archive records of cytology for the period of approximately 9,5 years, comparing them with patient demographic charecteristics, and discuss the results for women under age of 35. MATERIALS AND METHODS A total of 32,578 cases of Pap smears were retrieved and analysed from our archive included the Pap tests performed between January 2001 and April 2010 at the Early Cancer Screening, Diagnosing and Education Center by the consent of three pathologists via utilizing the Bethesda System Criteria 2001 and the results were compared with some demographical characteristics. RESULTS Our rate of the cervical cytological abnormality was 1.83%, with ASCUS in 1.18%, LSIL in 0.39, HSIL in 0.16%, AGUS in 0.07%, squamous cell carcinoma in 0.02%, and adenoarcinoma in 0.006%. Cytological abnormalities were detected mostly in those with higher age, lower parity, and premenopausal period whereas the smoking status was without influence. Bacterial vaginosis (5.6%) was the most frequent infectious finding (Candida albicans 2.7%; Actinomyces sp. 1.3%; and Trichomonas vaginalis 0.2%) detected on the smears. The rate of abnormal cervical cytology was 9.5% among the women aged between 30-34. CONCLUSIONS Early detection of the cervical abnormalities by means of the regular cervical cancer screening programmes is useful to attenuate the incidence, mortality, and morbidity of cervical cancer. Our prevalence of the cytological abnormalities was much lower than the one in Western populations in general but very similar to those reported from other Islamic countries that may be explained by the conservative lifestyle and the lower prevalence of HPV in Turkey. A remarkable rate of abnormal cervical cytology of women aged 30-34 was pointed out in the present study.


North American Journal of Medical Sciences | 2011

An elective detection of an Amyand's hernia with an adhesive caecum to the sac: Report of a rare case

Ilker Sengul; Demet Sengul; Duygu Aribas

Context: Existence of non-inflamed or inflamed vermiform appendix in an inguinal hernia is named Amyands hernia in honor to the surgeon Claudius Amyand who successfully performed first perforated appendicitis. Case Report: A 69-year-old Turkish male patient with a slight right groin pain and swelling was presented to our clinic, and found to have a slightly tender and reducible right inguinal hernia. He underwent surgery under general anesthesia, and a adhesive caecum and an inflamed appendix were explored within the hernia sac. Adhesions were divided by sharp dissection and appendectomy was performed. After carrying out a Lichtenstein hernioplasty, a broad-spectrum antibiotic was postoperatively admitted for 3 days. He recovered uneventfully, and neither complication nor recurrence was detected during 52 months of follow-up. Conclusions: Although occurrence of an appendicitis in an inguinal hernia is rare, a surgeon should be vigilant for facing with it even in elective cases. Treatment can be provided only surgically, but surgical treatment is not standard except from appendectomy. In our opinion, application of mesh hernia repair should depend on the degree of inflammation of appendix and the presence of incarceration of hernia sac with a suitable antibiotic admission for 3-5 days postoperatively.


Kaohsiung Journal of Medical Sciences | 2011

Ectomesenchymal chondromyxoid tumor of the anterior tongue: a rare case.

Demet Sengul; Ilker Sengul; Mehmet Umit Ozdol; Müzeyyen Astarci; Hüseyin Üstün

Ectomesenchymal chondromyxoid tumor is a rare tumor seen in the anterior dorsal aspect of the tongue. Diagnosis of this lesion without a prediagnosis clinically is made only with histopathological findings including the immunohistochemical examinations. However, diverse results are being reported in the literature with keratin staining. While glial fibrillary acid protein positiveness maintain being a fixed repeating feature, we emphasized for our case of a 28‐year‐old Caucasian woman having the findings of qualities supporting the ectomesenchymal origin of the mentioned tumor.


Cases Journal | 2010

Gangrenous meckel's diverticulum in a strangulated umbilical hernia in a 42 year-old woman: a case report

Ilker Sengul; Demet Sengul; Serhat Avcu; Omer Parlak

IntroductionMeckels diverticulum affects 1 - 3% of general population and is known as the most common anomaly of gastrointestinal tract. However, its estimated lifetime complication rate is approximately 4%. Intestinal obstruction is most common complication of Meckels diverticulum in adult population.Case presentationIn the present study, we reported a 42-year-old female patient with a gangrenous Meckels diverticulum in a strangulated umbilical hernia sac treated by dissection of diverticulomesenteric bands and diverticulectomy. In 36 months follow-up, there was neither any complication nor recurrence of hernia.ConclusionThis case represents a gangrenous Meckels diverticulum in a strangulated umbilical hernia sac diagnosed in case of emergency. Although it is a very rare phenomenon, we should be vigilant for this entity especially in case of emergency.


North American Journal of Medical Sciences | 2011

Pleomorphic adenoma of the lower lip: A rare site of location

Ilker Sengul; Demet Sengul; Duygu Aribas

Context: Pleomorphic adenoma is the most common neoplasm of the minor salivary glands which are uncommon among the entire salivary gland tumors. The lower lip is a very rare site of occurrence for pleomorphic adenoma. We intended to present a case of pleomorphic adenoma of the lower lip. Case Report: A 49-year-old Turkish man presented with the painless mass on his lower lip. A total excision was choiced for the mass by both we and the patient because of some cosmetic reasons. The histopathological evaluation revealed the diagnosis of pleomorphic adenoma and neither complication nor recurrence was observed during a clinical follow-up for 40 months. Conclusions: A clinician should be vigilant for the possibility of existence of a pleomorphic adenoma located on the lower lip even it is rare. Once it is diagnosed concisely, a wide excision is suggested in general if there is no cosmetic care and no risk of damage to functional structures of head and neck.


Oncology Letters | 2015

Significance of androgen receptor and CD10 expression in cutaneous basal cell carcinoma and trichoepithelioma

Hesna Muzeyyen Astarci; Gulfem A. Gurbuz; Demet Sengul; Sema Hucumenoglu; Uğur Koçer; Hüseyin Üstün

Differential diagnosis of trichoepithelioma (TE) and basal cell carcinoma (BCC) on the basis of clinical symptoms and laboratory investigations may be difficult in certain patients. The aim of the present study was to compare cluster of differentiation 10 (CD10) and androgen receptor (AR) expression patterns in BCC and TE, to investigate the predictive power of these proteins as markers of the two conditions. A total of 39 cases of BCC and 15 cases of TE were retrieved from the pathology department archives. AR and CD10 immunohistochemistry was performed on all of the specimens; 23 BCC cases displayed focal nuclear AR staining, however, none of the cases demonstrated diffuse nuclear staining and 16 BCC cases were negative for AR staining. Stromal CD10 staining was more common in TE cases than in BCC cases, and peripheral CD10 staining was more common in BCC cases than in TE cases. AR immunostaining of the BCC samples typically appeared as scattered clusters and individual cells. In addition, AR and CD10 staining exhibited varying staining intensities within each samples. Incisional punch biopsy specimens have the potential to present false-negative results. Therefore, AR and CD10 staining of total excision biopsies provides a more accurate differential diagnosis of BCC and TE for cases with difficulties in the histopathological analysis.


Kaohsiung Journal of Medical Sciences | 2013

Postconditioning attenuates acute intestinal ischemia–reperfusion injury

Ilker Sengul; Demet Sengul; Osman Guler; Adnan Hasanoglu; Mustafa Kemal Urhan; Ahmet Sukru Taner; Jakob Vinten-Johansen

The aim of this study was to test the hypothesis that postconditioning (POC) would reduce the detrimental effects of the acute intestinal ischemia–reperfusion (I/R) compared to those of the abrupt onset of reperfusion. POC has a protective effect on intestinal I/R injury by inhibiting events in the early minutes of reperfusion in rats. Twenty‐four Wistar–Albino rats were subjected to the occlusion of superior mesenteric artery for 30 minutes, then reperfused for 120 minutes, and randomized to the four different modalities of POC: (1) control (no intervention); (2) POC‐3 (three cycles of 10 seconds of reperfusion–reocclusion, 1 minute total intervention); (3) POC‐6 (six cycles of 10 seconds of reperfusion–reocclusion, 2 minutes total intervention); and (4) sham operation (laparotomy only). The arterial blood samples [0.3 mL total creatine kinase (CK) and 0.6 mL malondialdehyde (MDA)] and the intestinal mucosal MDA were collected from each after reperfusion. POC, especially POC‐6, was effective in attenuating postischemic pathology by decreasing the intestinal tissue MDA levels, serum total CK activity, inflammation, and total histopathological injury scores. POC exerted a protective effect on the intestinal mucosa by reducing the mesenteric oxidant generation, lipid peroxidation, and neutrophil accumulation. The six‐cycle algorithm demonstrated the best protection.


Journal of Maternal-fetal & Neonatal Medicine | 2014

Myometrial elasticity determined by elastosonography to predict preterm labor

Enis Ozkaya; Alptekin Tosun; Vakkas Korkmaz; Emine Küçük; Demet Sengul; Tuncay Küçüközkan

Abstract Aim: To determine the utility of elastosonography (ES) combined to cervical length measurement to predict preterm labor. Methods: One hundred twenty-seven women with pregnancies between 21 to 36 weeks of gestation without any risk factor for preterm labor were included in the study. All subjects underwent sonographic evaluation including fetal biometry, cervical length measurement and ES of uterine myometrium. Subcutaneous tissue was the reference point for ES evaluation. Tissue strain ratio values were obtained from all patients. Results: Cervical length was a significant predictor for preterm delivery (AUC = 0.958, p < 0.001). Optimal cut-off value was obtained at 30 mm with 92% sensitivity and 81% specificity. Elastosonographic strain ratio was also a significant predictor for preterm delivery (AUC = 0.827, p < 0.001). Optimal cut-off value was obtained at 4.7 with 79% sensitivity and 91% specificity. In linear regression analysis, strain ratio (R2 = 0.61, beta = 0.171, p = 0.03) and cervical length (R2 = 0.61, beta = −0.516, p < 0.001) were significantly associated with preterm delivery. Cervical length < 30 mm [39.1 (95 CI, 6.6–231.5, p < 0.001)] and strain ratio > 4.7 [24.5 (95 CI, 4.1–146.5, p < 0.001)] were the risk factors for preterm delivery. Conclusion: Elastosonographic evaluation of uterine myometrium was found to be significantly correlated with cervical length but cervical length measurement is a better predictor for preterm labor than ES.


North American Journal of Medical Sciences | 2011

Pleomorphic adenoma of the lower lip: A review

Ilker Sengul; Demet Sengul

The lower lip is a very rare emerging site for pleomorphic adenoma. The present review is to accentuate the definition, frequency, clinical and histopathological features, differential diagnosis, prognosis, and treatment choices of pleomorphic adenoma. We reviewed the English-language literature addressing pleomorphic adenoma of the lower lip. The tumors of minor salivary glands are not frequent among whole salivary glands tumors. Pleomorphic adenoma is the most common neoplasm among the minor salivary glands. A wide excision is recommended if there is no cosmetic care and no risk of damage to the functional structures of head and neck. Malignancy of the minor salivary glands are not rare. In addition, malignant transformation of pleomorphic adenoma involved in the benign tumors of minor salivary glands are possible. Thus, awareness of the possibility of existence of a pleomorphic adenoma or a malignant tumor within a mass located on the lower lip has a mentionable importance.


African Journal of Paediatric Surgery | 2011

Meckel's diverticulum in a strangulated umbilical hernia

Ilker Sengul; Demet Sengul

Sir, Meckel’s diverticulum (MD) was determined by Meckel on a small bowel diverticula in 1800.[1] It is the most common anomaly of gastrointestinal tract and reported to occur in 1-3% of general population and autopsy series.[2] The co-occurence of MD and umbilical hernia (UH) is very rare in the literature.[3] Although Meckel’s diverticulum is the most common anomaly of the gastrointestinal tract affecting 1-3% of general population, Meckel’s diverticulum in a strangulated UH is very rare. The most common complication of Meckel’s diverticulum is bleeding in children, unlike intestinal obstruction in the adult population. Although it is rare, a clinician should be vigilant for this entity especially in the case of an abdominal emergency of a non-trauma origin. The clinical features of strangulated Meckel’s diverticulum in an UH are documented.[3]

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