Demetra Antimisiaris

QUETIAPINE-INDUCED DYSTONIA AND AGITATION IN PARKINSON'S DISEASE WITH DEMENTIA: A CASE REPORT

DESCRIPTION An 80-year-old Caucasian man with a 4-year history of idiopathic PD with dementia had new-onset hallucinations, describing ‘‘cats in the walls,’’ 2 weeks before presentation. This escalated to aggressive behavior toward his wife and falls that resulted in hospitalization. His past medical history was remarkable for PD since 2003, a diagnosis of dementia in 2006, and hypertension. He was dependent in activities of daily living except eating. Medications were carbidopa/levodopa, 25/100 mg 1.5 tab three times a day; verapamil; hydrochlorothiazide/triamterene; fosinopril; citalopram; and trazodone. At admission, he had stable vital signs, and he was alert and awake, but with limited attention. Oriented to person only, he was unable to answer most questions appropriately. Physical examination was remarkable for cog wheeling and rigidity in all four extremities. Laboratory studies upon admission showed a blood urea nitrogen of 20 mg/dL and serum creatinine of 1.8 mg/dL. His mental status improved with intravenous hydration, but the aggressive behavior continued. A trial dose of quetiapine 12.5 mg orally was given. Within 3 hours of administration, the patient became more restless with increased muscle tone, twitching and spasms of arms and legs, and contracture-like positioning, but he remained afebrile with stable vital signs. Evaluation was negative for stroke, seizure, infection, or cardiac disease, suggesting a reaction to quetiapine manifested as dystonia and restlessness. Quetiapine was discontinued, and lorazepam was used to control agitation and relax the musculature. Dystonic symptoms improved within 48 hours, and after stabilization of other medical problems, the patient was transferred to a skilled nursing facility for ongoing care.

Tamoxifen Pharmacovigilance: Implications for Safe Use in the Future

OBJECTIVE To survey the status of current tamoxifen pharmacovigilance documentation reflecting tamoxifen use in an academic outpatient multispecialty practice in older adults. This data will help provide information to develop improved pharmacovigilance for a growing cohort of older adult users. The data will be utilized by an interdisciplinary team developing new methods of identifying factors for individualized pharmacovigilance in older adults. DESIGN Retrospective chart review to gather descriptive and quantitative data on tamoxifen pharmacovigilance. SETTING Multi-specialty clinic. PATIENTS Ninety-three patients 60 years of age and older. MAIN OUTCOME MEASURES Quantitative report of tamoxifen monitoring as well as descriptive analysis of individual cases. RESULTS We found 19 cases of serious adverse events possibly related to tamoxifen (thrombi, uterine malignancies). There were 15 cases with no documentation of pharmacovigilance. All cases had incomplete pharmacovigilance documented. There were two cases of hypercalcemia. There was one case of tamoxifen discontinuation resulting from muscle pain and with chronic muscle pain complaints while receiving tamoxifen. We observed a correlation in older age or high comorbidity burden patients and adverse events patients. CONCLUSION Some studies direct the important pharmacovigilance toward prevention of thrombi, uterine malignancies, and hypercalcemia; however, it is not easy to identify recommendations for frequency or focus of monitoring to prevent adverse events for individual older adults based on existing recommendations. The data collected and presented in this study serve to heighten awareness of tamoxifen pharmacovigilance and as a starting point for the application of machine learning techniques and modeling to identify high-risk patients and individualized pharmacovigilance recommendations.

Managing Polypharmacy in the 15-Minute Office Visit.

Polypharmacy is an underappreciated factor in undesirable patient outcomes. In older adults, polypharmacy is considered a syndrome of harm and presents a challenge to primary care providers. The United States has one of the highest medication use rates per capita in the world. With the aging population, and polypharmacy a significant part of the lives of older adults, management of polypharmacy poses both a growing challenge and an opportunity for all health care providers. This article provides an overview of skills to improve medication use management in older adults living with polypharmacy.

Predicting asthma in older adults on the basis of clinical history

BACKGROUND The diagnosis of asthma is not always straightforward and can be even more challenging in older adults. Asthma is ideally confirmed by demonstration of variable expiratory airflow limitation. However, many patients with asthma do not demonstrate airflow obstruction nor show bronchodilator reversibility. We aimed to investigate predictors for a positive bronchial challenge test with methacholine in older adults being evaluated for asthma. METHODS This is a diagnostic accuracy study with a cross-sectional design. Participants ≥60 years with suspected asthma and a negative postbronchodilator response on spirometry were included. All participants underwent a methacholine challenge test (MCT). We assessed the value of standard asthma screening questions and additional clinical questions to predict the MCT results. A multivariable logistic regression model was developed to assess the variables independently impacting the odds of a positive MCT result. RESULTS Our study included 71 participants. The majority were female (n = 52, 73.2%) and the average age was 67.0 years. Those with a positive MCT (n = 55, 77.5%) were more likely to have wheezing or coughing due to allergens (n = 51, 92.7% vs. n = 12, 75.0%; P = 0.004) and difficulty walking several blocks (n = 14, 25.5% vs. n = 1, 6.3%, P = 0.009). After adjustment, having wheezing or coughing due to allergens (OR = 4.2, 95% CI 1.7-7.8, P = 0.012) remained the only significant independent predictor of a positive MCT. CONCLUSIONS In older adults with suspected asthma, questioning about wheezing or coughing due to allergens provides a modest independent value to predict a MCT result in those who previously had a negative postbronchodilator response on spirometry.

Identifying phenotypes and factors impacting outcomes in older adults with asthma: A research protocol and recruitment results

Success in testing research outcomes requires identification of effective recruitment strategies in the targeted population. In this paper, we present the protocol for our NIH-funded study as well as success rates for the various recruitment strategies employed. This longitudinal observational study is: developing a phenotyping algorithm for asthma in older adults, exploring the effects of the asthma phenotype and of volatile organic compounds on asthma control, and developing a predictive model of asthma quality of life. A sub-aim is to characterize barriers to successful medication management in older adults with asthma. Individuals are eligible if they are ≥60 years, have a positive response to at least 1 of 6 asthma screening questions, are non-smokers, and demonstrate bronchodilator reversibility or a positive bronchial challenge test with methacholine. Exclusion criteria are smokers who quit <5 years ago or with a >20 pack year smoking history, and those having other chronic pulmonary diseases. Participants (N = 190) complete baseline pulmonary function testing, questionnaires, sputum induction, skin prick testing, and have blood drawn for Vitamin D and Immunoglobulin E. Home environmental assessments are completed including 24-hr particulate and volatile organic compound measurements. At 9-months post-baseline, home spirometry, medication assessment, and assessment of asthma quality of life and asthma control are assessed. At 18-months post-baseline, home spirometry, completion of baseline questionnaires, and a home environmental assessment are completed. We have employed multiple recruitment efforts including referrals from clinical offices, no-cost media events, flyers, and ads. The most successful efforts have been referrals from clinical offices and media events.

Implementing Chief Resident Immersion Training (CRIT) in the Care of Older Adults: Overcoming Barriers and Promoting Facilitators

The Chief Resident Immersion Training (CRIT) in the Care of Older Adults curriculum was developed at Boston University School of Medicine to improve the care of older adults through an educational intervention. The curriculum targeted chief residents (CRs) because their role as mediators between learners and faculty provides the greatest potential impact for transmitting knowledge. The goals of CRIT are to: (1) provide education on geriatric principles and on teaching/leadership skills, (2) foster interdisciplinary collaboration, and (3) complete an action project. This study demonstrates successful implementation of CRIT at a different academic institution in a rural state. The CRs indicated that their confidence in their ability to apply and teach geriatrics improved after CRIT. In addition, the CRs indicated that CRIT improved their confidence in their overall skills as CRs. The barriers and facilitators to implementation are addressed in order to promote successful adoption of CRIT at other institutions, including those in rural states.