Demondes Haynes
University of Mississippi
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Publication
Featured researches published by Demondes Haynes.
European Respiratory Journal | 2014
Kristin M. Burkart; Ani Manichaikul; Jemma B. Wilk; Firas S. Ahmed; Gregory L. Burke; Paul L. Enright; Nadia N. Hansel; Demondes Haynes; Susan R. Heckbert; Eric A. Hoffman; Joel D. Kaufman; Jun Kurai; Laura R. Loehr; Stephanie J. London; Yang Meng; George T. O'Connor; Elizabeth C. Oelsner; Marcy F. Petrini; Tess D. Pottinger; Charles A. Powell; Susan Redline; Jerome I. Rotter; Lewis J. Smith; María Soler Artigas; Martin D. Tobin; Michael Y. Tsai; Karol E. Watson; Wendy White; Taylor R. Young; Stephen S. Rich
Chronic obstructive pulmonary disease (COPD) is linked to cardiovascular disease; however, there are few studies on the associations of cardiovascular genes with COPD. We assessed the association of lung function with 2100 genes selected for cardiovascular diseases among 20 077 European-Americans and 6900 African-Americans. We performed replication of significant loci in the other racial group and an independent consortium of Europeans, tested the associations of significant loci with per cent emphysema and examined gene expression in an independent sample. We then tested the association of a related lipid biomarker with forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio and per cent emphysema. We identified one new polymorphism for FEV1/FVC (rs805301) in European-Americans (p=1.3×10−6) and a second (rs707974) in the combined European-American and African-American analysis (p=1.38×10−7). Both single-nucleotide polymorphisms (SNPs) flank the gene for apolipoprotein M (APOM), a component of high-density lipoprotein (HDL) cholesterol. Both were replicated in an independent cohort. SNPs in a second gene related to apolipoprotein M and HDL, PCSK9, were associated with FEV1/FVC ratio among African-Americans. rs707974 was associated with per cent emphysema among European-Americans and African-Americans and APOM expression was related to FEV1/FVC ratio and per cent emphysema. Higher HDL levels were associated with lower FEV1/FVC ratio and greater per cent emphysema. These findings suggest a novel role for the apolipoprotein M/HDL pathway in the pathogenesis of COPD and emphysema. Findings from this study suggest a novel effect of the APOM/HDL pathway in the pathogenesis of COPD and emphysema http://ow.ly/t8Ao9
Chest | 2011
DeMarc A. Hickson; Heba Abed; Ravi K.Gawalapu; Marcy F. Petrini; Demondes Haynes; Jiankang Liu; J. Jeff Carr; Herman A. Taylor
american thoracic society international conference | 2010
Ketan Patel; Demondes Haynes; Marcy F. Petrini
Chest | 2018
Lewis Aldred; Demondes Haynes; Allyn Harris
Chest | 2017
Jeffrey Grondin; Demondes Haynes
american thoracic society international conference | 2012
Benedict E. Ewaleifoh; Ragesh Bhagat; Marcy F. Petrini; Demondes Haynes; Terry M. Dwyer
american thoracic society international conference | 2011
George E. Abraham; Marcy F. Petrini; Demondes Haynes
american thoracic society international conference | 2011
Joe M. Pressler; Demondes Haynes; Marcy F. Petrini
american thoracic society international conference | 2011
Kristin M. Burkart; Melinda C. Aldrich; Jemma B. Wilk; Rhea Powell; Sarah G. Buxbaum; Paul L. Enright; Nadia N. Hansel; Demondes Haynes; Susan R. Heckbert; Laura R. Loehr; Stephanie J. London; Helen N. Lyon; Ani Manichaikul; Marcy F. Petrini; Susan Redline; Lewis J. Smith; Wendy White; Stephen S. Rich; R. G. Barr
american thoracic society international conference | 2010
Rafat Mohammed; Marcy F. Petrini; John R. Spurzem; Demondes Haynes