Denise R. Dunlap

A Story of Breakthrough vs. Incremental Innovation: Corporate Entrepreneurship in the Global Pharmaceutical Industry

Breakthrough innovations are difficult to create; yet they are critical to long term competitive advantage. This highlights the considerable opportunities and risks that face corporate entrepreneurs. We study the complex explorative and exploitative entrepreneurial processes of multinational firms operating in the global pharmaceutical industry. We analyze over 1,500 new drug approvals by the U.S. Food and Drug Administration (FDA). We find that a successful track record in breakthrough innovation significantly increases the likelihood of a current breakthrough, while achievements in non-generic incremental innovation do not have a significant effect. A strong foundation in generic incremental innovation hinders breakthrough performance. Thus, incremental innovation processes appear to be heterogeneous. Products that emerge from joint ventures and alliances are more likely to be breakthroughs. Foreign subsidiary participation in innovation processes did not significantly inhibit breakthroughs. These suggestive findings support the decentralization literature that highlights the benefits associated with exploiting knowledge from foreign centers of excellence. Contrary to the literature arguing that younger firms tend to have greater advantages in “exploration”, we do not find firm age to be a significant predictor of the likelihood of breakthrough innovation.

The university entrepreneur: a census and survey of attributes and outcomes

This study looks at 400 technology transfer disclosures and their inventors over a 10‐year period at a large US research university. We find that faculty productivity in terms of patenting is not related to commercialization success, but entrepreneurial qualities are significantly correlated. Results indicate that the significant factors in successfully forming a university spin‐out are the level of experience of the faculty member and participation in an industry sponsored research agreement. We also find that the academic inventors entrepreneurial experience and inclination toward commercialization have the most positive impacts on the formation of a new venture.

Organizing for Innovation Ambidexterity in Emerging Markets Taking Advantage of Supplier Involvement and Foreignness

Firms struggle to be ambidextrous in the sense of being able to successfully manage both new and incremental innovation activities simultaneously. Applying the knowledge-based view, we examine the important moderating influences of supplier involvement and foreignness on the relationship between innovation ambidexterity and performance. We test our hypotheses at the business-unit level of analysis in the emerging market of Brazil. We examine two types of innovation ambidexterity: the balanced dimension and the combined dimension. We found that firms possessing greater supplier involvement reap higher performance benefits from the combined dimension of innovation ambidexterity. Last, foreign subsidiaries also achieved higher levels of performance than domestic firms from the combined dimension of innovation ambidexterity.

The role of cross-national knowledge on organizational ambidexterity: A case of the global pharmaceutical industry

Using a sample of 70 global pharmaceutical firms, this study examined how cross-national knowledge affected the creation of exploitative (incremental) and explorative (breakthrough) types of technological innovations both of which are necessary for organizational ambidexterity. We found that there were significant differences for effectively using cross-national knowledge, which reinforces the need for organizational ambidexterity. The data used to study cross-national knowledge consisted of patent analyses of commercialized products, which is a step further than most studies that stop at just the patents themselves. Through the use of double-log regression analysis, the results suggested a notable conclusion: while the sourcing of intrafirm, cross-national knowledge enhanced explorative or breakthrough innovation, it did not enhance the development of exploitative or incremental innovation. The article concludes with managerial implications for managing ambidexterity.

A critical assessment of Brazilian manufacturing competitiveness in foreign markets

This study aims to examine the competitiveness of firms operating in the emerging economy of Brazil. This study examines the current perception of Brazilian business leaders regarding the level of competitiveness in various sectors of industrial activity and the country’s business environment.,Survey data were collected in a joint study developed by Brazilian School of Public and Business Administration (EBAPE) and the Brazilian Institute of Economics (IBRE). The population surveyed was composed of businessmen, managers and directors of Brazilian manufacturing firms. This survey was created based on a similar survey conducted by the Harvard Business School, which was also aimed at identifying the reasons behind national loss of competitiveness.,The results of the survey point out that the worsening competitive nature of companies operating in Brazil can be primarily attributed to the deterioration of its country-specific advantages and in particular those linked to government policies, services and bureaucratic procedures, all of which bear a negative impact on the country’s business environment.,Future research should explore in more depth the specific types of initiatives that these firms have and are continuing to eagerly adopt with the aim of improving their domestic competitiveness and, namely, firm-specific advantages, whether it be by contributing to the improvement of the business environment as a whole, or by improving their own operations and management systems.,The main obstacles related to competitiveness are associated with the “Brazil Cost”, namely, the tax system, infrastructure, political system, labor laws and bureaucracy that do not appear to offer much room for maneuvering in terms of reducing these barriers in the short term. Managers not addressing these important input factors of competitiveness not only divert attention away from innovation and creativity but also could lead to more serious political, social welfare and economic implications in the global marketplace.,This study helps to gain a better understanding of the initiatives that could and are being used to contribute to a fruitful discussion about leading public policies and government actions geared toward upgrading Brazil’s business environment and country competitiveness as a whole.,This research contributes to the understanding of the initiatives that could and are being used to improve firm competitiveness in Brazil. These initiatives contribute to a fruitful discussion about leading public policies and government actions geared toward upgrading Brazil’s business environment and country competitiveness as a whole.